IP Library › Granted Patent US 8,604,042
Granted Patent B2
US 8,604,042 · App. 12/862,517 · Granted Dec 10, 2013

Bi-aryl meta-pyrimidine inhibitors of kinases

Inventors: Glenn Noronha (Seattle, WA); Chi Ching Mak (San Diego, CA); Jianguo Cao (San Diego, CA); Joel Renick (San Diego, CA); Andrew McPherson (San Diego, CA); Binqi Zeng (San Diego, CA); Ved P. Pathak (San Diego, CA); Daniel L. Lohse (Silvis, IL); John D. Hood (San Diego, CA); Richard M. Soll (San Diego, CA)
Assignee: TargeGen, Inc.
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Quick Facts
Patent No.
US 8,604,042
App. No.
12/862,517
Granted
Dec 10, 2013
Kind
B2
Abstract

The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Claims (5)

1. A compound, or a salt thereof, wherein the compound is of the formula selected from the group consisting of:

2. The compound of claim 1 , or a salt thereof, wherein the compound is of the formula 33:

3. The compound of claim 1 , or a salt thereof, wherein the compound is of the formula 32:

4. The compound of claim 1 , or a salt thereof, wherein the compound is selected from the group consisting of:

5. The compound of claim 1 , or a salt thereof, wherein the compound is selected from the group consisting of:

Assignments (9)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S NAME PREVIOUSLY RECORDED AT REEL: 042512 FRAME: 0179. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Aug 21, 2019
From: TARGEGEN, INC.
To: IMPACT BIOMEDICINES, INC.
Reel/Frame 050297/0562 →
RELEASE OF SECURITY INTEREST Recorded Feb 12, 2018
From: LIND SA LLC, AS COLLATERAL AGENT
To: IMPACT BIOMEDICINES, INC.
Reel/Frame 044904/0628 →
SECURITY INTEREST Recorded Nov 30, 2017
From: IMPACT BIOMEDICINES, INC.
To: LIND SA, LLC, AS COLLATERAL AGENT
Reel/Frame 044572/0660 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2017
From: TARGEGEN, INC.
To: IMPACT THERAPEUTICS, INC.
Reel/Frame 042512/0179 →
CHANGE OF NAME Recorded May 25, 2017
From: IMPACT THERAPEUTICS, INC.
To: IMPACT BIOMEDICINES, INC.
Reel/Frame 042586/0643 →
CORRECTIVE ASSIGNMENT TO CORRECT THE STATE OF INCORPORATION FROM A CALIFORNIA CORPORATION TO A DELAWARE CORPORATION FOR THE ASSIGNMENT PREVIOUSLY RECORDED ON REEL 025154 FRAME 0975. ASSIGNOR(S) HEREBY CONFIRMS THE STATE OF INCORPORATION FOR TARGEGEN, INC. TO BE A DELAWARE CORPORATION. Recorded Oct 29, 2013
From: NORONHA, GLENN; MAK, CHI CHING; CAO, JIANGUO; RENICK, JOEL; MCPHERSON, ANDREW; ZENG, BINQI; PATHAK, VED P.; LOHSE, DANIEL L.; HOOD, JOHN D.; SOLL, RICHARD M.
To: TARGEGEN, INC.
Reel/Frame 031510/0268 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2010
From: NORONHA, GLENN; MAK, CHI CHING; CAO, JIANGUO; RENICK, JOEL; MCPHERSON, ANDREW; ZENG, BINQI; PATHAK, VED P.; LOHSE, DANIEL L.; HOOD, JOHN D.; SOLL, RICHARD M.
To: TARGEGEN, INC.
Reel/Frame 025154/0975 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2010
From: HOOD, JOHN D.; NORONHA, GLENN
To: TARGEGEN, INC.
Reel/Frame 025155/0047 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2010
From: NORONHA, GLENN; MAK, CHI CHING; CAO, JIANGUO; RENICK, JOEL; MCPHERSON, ANDREW; ZENG, BINQI; PATHAK, VED P.; LOHSE, DANIEL L.; HOOD, JOHN D.; SOLL, RICHARD M.
To: TARGEGEN, INC.
Reel/Frame 025155/0016 →
Continuity (9)
Continuation In Part 12251061 · Oct 14, 2008
Continuation In Part 11588638 · Oct 26, 2006
Continuation In Part 11796717 · Apr 26, 2007
Continuation In Part 11588638 · Oct 26, 2006
Continuation In Part 12253374 · Oct 17, 2008
Continuation 11588638 · Oct 26, 2006
Provisional Application 60732629 · Nov 1, 2005
Provisional Application 60838003 · Aug 15, 2006
Related Publication 20110212077A1 · Sep 1, 2011