Angiotensin II receptor antagonists
View Patent ↗A compound having the structure wherein R is an angiotensin receptor blocking group Y is —(CR 1 R 20 ) 1-7 R 5 , or —C(O)(CR 1 R 20 ) 1-7 R 5 ; R 1 and R 20 are independently selected from the group consisting of hydrogen or C 1-4 alkyl; R 5 is —O—N═N(O)—NR 3 R 4 ; and R 3 and R 4 are independently selected from the group consisting of —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 , —C 1-4 alkyl, unsubstituted or substituted C 1-6 alkenyl, unsubstituted or substituted morpholino, amino, unsubstituted or substituted benzyl, unsubstituted or substituted phenyl, unsubstituted or substituted arylC 1-4 alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof, which is useful for treating hypertension.
1. A compound having the general formula:
wherein R is
Y is —(CR 1 R 20 ) 1-7 R 5 , or —C(O)(CR 1 R 20 ) 1-7 R 5 ;
R 1 and R 20 are independently selected from the group consisting of hydrogen or C 1-4 alkyl;
R 5 is —O—N═N(O)—NR 3 R 4 ;
R 3 and R 4 together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of
Q is selected from the group consisting of S, O and NR 6 ;
R 6 , R 8 and R 9 are independently selected from the group consisting of hydrogen and unsubstituted or substituted C 1-6 alkyl;
R 12 and R 13 are independently selected from the group consisting of —OH, —CH 2 OH, —CH 2 CH 2 OH, —COOH, and —CH 2 COOH;
or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof.
2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 is H or CH 3 .
3. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 3 and R 4 , together with the nitrogen atom to which they are attached, form a ring selected from the group consisting of
4. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 8 and R 9 are hydrogen.
5. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, selected from the group consisting of
6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
7. A pharmaceutical composition comprising a compound of claim 1 , a diuretic, and a pharmaceutically acceptable carrier.
8. A method for treating hypertension in a patient which comprises administering to the patient a therapeutically effective amount of the composition of claim 6 .
9. A pharmaceutical composition comprising a compound of claim 5 and a pharmaceutically acceptable carrier.
10. A pharmaceutical composition comprising a compound of claim 5 , a diuretic, and a pharmaceutically acceptable carrier.
11. A method for treating hypertension in a patient which comprises administering to the patient a therapeutically effective amount of the composition of claim 10 .