Oligome-cannabinoid conjugates
View Patent ↗The invention relates to (among other things) oligomer-cannabinoid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated cannabinoid compounds.
1. A compound having the following structure:
wherein:
X is a spacer moiety; and
POLY is a water-soluble, non-peptidic oligomer, wherein the water-soluble, non-peptidic oligomer is made of 2 to 30 monomers.
2. The compound of claim 1 , wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).
3. The compound of claim 2 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).
4. The compound of claim 2 , wherein water-soluble, non-peptidic oligomer has between 2 and 20 monomers.
5. The compound of claim 4 , wherein the water-soluble, non-peptidic oligomer has between 2 and 10 monomers.
6. The compound of claim 2 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxy end-capping moiety.
7. The compound of claim 1 , wherein X is selected from —O—, —S—, —NH—, —C(O)—NH—, —NH—C(O)—, —O—C(O)—NH—, —NH—C(O)—O—, NH—C(O)—NH, or a covalent bond.
8. The compound of claim 1 , wherein X is —O—.
9. A composition comprising a compound of claim 1 , and optionally, a pharmaceutically acceptable excipient.
10. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.
11. A compound having the structure:
wherein n is 1 to 30.
12. The compound of claim 11 , wherein n is 1 to 9.
13. A composition comprising a compound of claim 11 , and optionally, a pharmaceutically acceptable excipient.