Vaccine compositions
The present invention provides methods for the treatment or prevention of allergic airways diseases, the suppression of allergic immune responses, and the induction protective immunity against allergic airways diseases wherein the methods comprise administering to subjects in need thereof an effective amount of a Streptococcus pneumoniae capsular polysaccharide and a Streptococcus pneumoniae exotoxin or exotoxoid, optionally together with one or more additional antigenic or immunomodulatory constituents, components or fractions of Streptococcus pneumoniae and/or immunopotentiators. Administration of individual components is also contemplated. Also provided are vaccine compositions suitable for use in accordance with methods disclosed herein.
1. A method for the treatment or prevention of an allergic airways disease in a subject, the method comprising administering to the subject an effective amount of a Streptococcus pneumoniae capsular polysaccharide and a Streptococcus pneumoniae exotoxin or exotoxoid; wherein
the capsular polysaccharide is the type 3 polysaccharide (T3P);
the exotoxin or exotoxoid is pneumolysin or pneumolysoid (Ply); and
the allergic airways disease is selected from asthma, asthma exacerbations, eosinophilic bronchitis, allergic rhinitis, chronic cough, sinusitis, angioedema, urticaria, chronic obstructive pulmonary disease, conjunctivitis and hay fever.
2. The method of claim 1 further comprising the administration of one or more additional antigenic or immunomodulatory constituents, components or fractions of Streptococcus pneumoniae , selected from purified cell walls, cell wall peptidoglycan, lipoteichoic acid, polysaccharides, protein, lipids, carbohydrates, glycoproteins, and fragments thereof.
3. The method of claim 2 wherein the additional constituent, component or fraction is purified Streptococcus pneumoniae cell wall.
4. The method of claim 3 wherein the purified cell wall is derived from an unencapsulated Streptococcus pneumoniae strain.
5. The method of claim 1 further comprising the administration of an immunopotentiator.
6. The method of claim 5 wherein the immunopotentiator comprises CpG oligonucleotides.
7. The method of claim 1 comprising the administration of T3P, Ply, purified cell wall from an unencapsulated Streptococcus pneumoniae strain and CpG oligonucleotides.
8. The method of claim 1 comprising the administration of T3P, Ply and purified cell wall from an unencapsulated Streptococcus pneumoniae strain.
9. The method of claim 1 comprising the administration of T3P, Ply and CpG oligonucleotides.
10. The method of claim 1 wherein the treatment or prevention prevents or suppresses the onset of an allergic airways disease, induces protective immunity against an allergic airways disease or suppresses an allergic immune response.
11. The method of claim 10 wherein the allergic immune response is associated with eosinophilia, mucous secreting cell expression, airway hyperresponsiveness and/or any Th2-mediated immune response.