(Dihydro)pyrrolo[2,1-α]isoquinolines

1. A compound according to formula I

or a pharmaceutically acceptable salt thereof, wherein

the C5-C6 bond can either be saturated or unsaturated,

R 1 is halogen, cyano, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (3-6C)cycloalkyl, (5-6C)cycloalkenyl, or phenyl or heteroaryl containing 1-5 carbon atoms and 1-4 heteroatoms selected from N, O, and S, each of said phenyl and heteroaryl moieties being independently optionally substituted with one or more substituents selected from R 13 ;

R 2 is H, cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, hydroxy(1-4C)alkyl, formyl, (1-4C)alkylcarbonyl or C═N—OH, C═N—OCH 3 ;

R 3 is (R 15 )(R 16 )N— or

R 3 is (1-6C)alkyl, (3-6C)cycloalkyl, ((1-4C)alkyl) 1-2 N(1-4C)alkyl, or

R 3 is a saturated heterocycle-(1-4C)alkyl-, wherein the heterocycle contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, the heterocycle moiety of which optionally may be substituted with (1-4C)alkylcarbonyl or (3-6C)cycloalkylcarbonyl, or

R 3 is a group selected from

R 7 is H, halogen, or methyl;

R 8 is H, halogen, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkoxy(l-4C)alkyl or hydroxy;

R 9 is H, formyl, halogen, hydroxy, amino, cyano, nitro, (2-6C)alkynyl, (3-6C)cycloalkoxy, saturated heterocyle-O—, wherein the heterocycle group contains 2-5 carbon atoms and 1-3 heteroatoms selected from N, O and S, heteroaryl-O—, wherein the heteroaryl group contains 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, ((1-4C)alkyl) 1-2 NCOO—, (1-6C)alkylcarbonyl, (1-4C)alkoxycarbonyl, ((1-4C)alkyl) 1-2 NCO—, saturated heterocycle-CO—, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, ((1-4C)alkyl) 1-2 N—, saturated heterocycle-CONH—, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O, and S, ((1-4C)alkyl) 1-2 NCONH—, (1-4C)alkoxycarbonylamino, ((1-4C)alkyl) 1-2 NS(O) 2 NH—, (1-4C)alkylsulfonylamino, 1-imidazolidinyl-2-one, 3-oxazolidinyl-2-one, 1-pyrrolidinyl-2-one, or

R 9 is (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkenyl, (1-6C)alkylcarbonylamino or saturated heterocycle containing 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, heteroaryl-NHCO—, wherein the heteroaryl group contains 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, each of said alkyl, alkoxy, alkenyl, heterocycle and heteroaryl being independently optionally substituted with one or more substituents selected from R 14 , or

R 9 is heteroaryl containing 1-5 carbon atoms and 1-3 heteroatoms selected from N, O and S, phenyl or phenoxy, all independently optionally substituted with one or more substituents selected from R 13 ;

R 10 is H, methoxy, halogen or methyl;

R 11 is H, (1-6C)alkyl or (3-4C)alkenyl;

R 12 is (1-4C)alkylcarbonyl or (3-6C)cycloalkylcarbonyl, both optionally substituted with one or more substituents selected from R 13 ,

R 13 is hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio or ((1-4C)alkyl) 1-2 N—;

R 14 is hydroxy, amino, halogen, azide, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio, ((1-4C)alkyl) 1-2 N—, (3-6C)cycloalkyl, saturated heterocycle containing 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, (1-4C)alkylcarbonylamino, ((1-4C)alkyl) 1-2 NCONH—, (1-4C)alkylsulfonylamino, (1-4C)alkoxycarbonylamino, (1-4C)alkylcarbonyl, (1-4C)alkoxycarbonyl, (1-4C)alkylsulfoxy, saturated heterocycle-O—, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, ((1-4C)alkyl) 1-2 NCO—, (1-4C)alkylsulfonyl, (3-6C)cycloalkylcarbonylamino and [(1-4C)alkyl][(1-4C)alkylcarbonyl]amino;

R 15 and R 16 in (R 15 )(R 16 )N— are independently selected from H, or (1-6C)alkyl, (3-6C)cycloalkyl, saturated heterocycle containing 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S or ((1-4C)alkyl) 1-2 N—, all optionally substituted with hydroxy, (1 -4C)alkyl, (1 -4C)alkoxy, (1-4C)alkylcarbonyl, (1 -4C)alkoxycarbonyl, (3-6C)cycloalkylcarbonyl, ((1-4C)alkyl) 1-2 N—, ((1-4C)alkyl ) 1-2 NCO or ((1-4C)alkoxy(1-4)alkyl) 1-2 N—; or

(R 15 )(R 16 )N— are joint in a saturated heterocycle containing 3-8 carbon atoms and 2-3 heteroatoms selected from N, O and S ring, optionally substituted with R 18 or (R 15 )(R 16 )N— are joint in a saturated heterocycle containing 4-8 carbon atoms and 1 N atom or a unsaturated nonaromatic heterocycle containing containing 4-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, which both contain one nitrogen and which are optionally substituted with one or more substituents selected from R 17 ;

R 17 is hydroxy, amino, halogen, (1-4C)alkyl, (1-4C)alkoxy, ((1-4C)alkyl) 1-2 N—, (1-4C)alkylcarbonylamino, ((1-4C)alkyl) 1-2 NCONH—, (1-4C)alkylsulfonylamino, (1-4C)alkoxycarbonylamino, (1-4C)alkylsulfoxy, (3-6C)cycloalkylcarbonylamino, [(1-4C)alkyl][(1-4C)alkylcarbonyl]amino, or

R 17 is phenyl and heteroaryl containing 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, both optionally substituted with one or more substituents selected from R 13 ; and

R 18 is (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenylcarbonyl, ((1-4C)alkyl) 1-2 NCO (1-4C)alkylsulfonyl, ((1-4C)alkyl) 1-2 NSO 2 -, saturated heterocycle-SO 2 -, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S, heteroaryl containing 2-5 carbon atoms 1-4 heteroatoms selected from N, O and S, phenylcarbonyl, (1-4C)alkylcarbonyl, (3-6C) cycloalkylcarbonyl, heteroaryl-CO—, wherein the heteroaryl group contains 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, phenyl, phenylsulfonyl, heteroaryl containing 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S and saturated heterocycle-CO—, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, S and O, the (cyclo)alkyl and (hetero)aryl moieties of which can be substituted with one or more substituents selected from R 13 , with the proviso that the compound is not 3-acetyl-pyrrolo[2,1-a]isoquinoline-1-carbonitrile.

2. The compound according to claim 1 wherein the C5-C6 bond is saturated.

3. The compound according to claim 1 wherein R 1 is heteroaryl containing 1-5 carbon atoms and 1-3 heteroatoms selected from N, O and S, optionally substituted with one or more substituents selected from R 13 .

4. The compound according to claim 1 wherein R 2 is H, cyano, halogen, (1-4C)alkoxy(1-4C)alkyl or hydroxy(1-4C)alkyl.

5. The compound according to claim 1 wherein R 3 is (R 15 )(R 16 )N— or

6. The compound of claim 1 wherein R 7 is H.

7. The compound of claim 1 wherein R 8 is (1-4C)alkoxy or hydroxy.

8. The compound according to claim 1 wherein R 9 is halogen, cyano, nitro, (2-6C)alkynyl, (3-6C)cycloalkoxy, heterocycle-O—, wherein the heterocycle contains 2-5 carbon atoms and 1-3 heteroatoms selected from N, O and S, heteroaryl-O—, wherein the heteroaryl group contains 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, ((1-4C)alkyl) 1-2 NCO—, heterocycle-CO—, wherein the heterocycle group contains 2-6 carbon atoms and 1-3 heteroatoms selected from N, O and S or ((1-4C)alkyl) 1-2 N—, or

R 9 is (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkenyl, (1-6C)alkylcarbonylamino or heteroaryl-NHCO—, wherein the heteroaryl group contains 2-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, each of said alkyl, alkoxy, alkenyl or heteroaryl groups independently optionally substituted with one or more substituents selected from R 14 , or

R 9 is heteroaryl containing 1-5 carbon atoms and 1-4 heteroatoms selected from N, O and S or phenoxy, both indpendently optionally substituted with one or more substituents selected from R 13 .

9. The compound according to claim 8 wherein R 9 is halogen, cyano, nitro, (2-6C)alkynyl or ((1-4C)alkyl) 1-2 N—, or

R 9 is (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkenyl or (1-6C)alkylcarbonylamino, said alkyl, alkoxy or alkenyl groups independently optionally substituted with one or more substituents selected from R 14 , or

R 9 is heteroaryl containing 1-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more substituents selected from R 13 .

10. The compound according to claim 9 wherein R 9 is (2-6C)alkynyl, or

R 9 is (1-6C)alkyl, (1-6C)alkoxy, (2-6C)alkenyl, or (1-6C)alkylcarbonylamino, said alkyl, alkoxy or alkenyl groups independently optionally substituted with one or more substituents selected from R 14 , or

R 9 is heteroaryl containing 1-5 carbon atoms and 1-4 heteroatoms selected from N, O and S optionally substituted with one or more substituents selected from R 13 .

11. The compound according to claim 1 wherein R 10 is H.

12. The compound according to claim 8 wherein R 1 is heteroaryl containing 1-5 carbon atoms and 1-4 heteroatoms selected from N, O and S, optionally substituted with one or more substituents selected from R 13 , R 2 is H, R 3 is (R 15 )(R 16 )N—, R 7 is H, R 8 is (1-4C)alkoxy and R 10 is H.

13. The compound according to claim 6 wherein R 14 is a saturated heterocycle containing 2-6 carbon atoms and 1-3 heteroatom selected from N, O and S, hydroxy, (1-4C)alkoxy or ((1-4C)alkyl) 1-2 N—.

14. The compound according to claim 6 wherein R 15 and R 16 may be independently selected from (1-6C)alkyl.

15. The compound according to claims 1 wherein R 3 is 1,4 diazacycloheptan-1-yl, optionally substituted with (1-4C)alkylcarbonyl or (3-6C)cycloalkylcarbonyl.

16. The compound according to claim 1 wherein R 3 is 2,2-dimethylpyrrolidin-1-yl.

17. The compound according to claim 1 selected from:

(9-Isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-[4-(tetrahydro-furan-2-carbonyl)-[1,4]diazepan-1-yl]-methanone;

1-[4-(9-Isopropoxy-8-methoxy--thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carbonyl)-[1,4]diazepan-1-yl]-2-methylsulfanyl-ethanone;

(9-Isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-[4-(thiophene-2-sulfonyl)-[1,4]diazepan-1-yl]-methanone;

3,3,3-Trifluoro-2-hydroxy-1-[4-(9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-3-carbonyl)1,4]diazepan-1-yl]-propan-1-one;

(4-Cyclobutanecarbonyl-[1,4]diazepan-1-yl)-(9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo [2,1 -α] isoquinolin-3-yl)-methanone;

3-(4-Cyclobutanecarbonyl-[1,4]diazepane-1-carbonyl)-9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-2-carbonitrile;

[4-(1-Bromo-cyclobutanecarbonyl)-[1,4]diazepan-1-yl]-(9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-methanone;

[4-(1-Hydroxy-cyclobutanecarbonyl)-[1,4]diazepan-1-yl]-(9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-methanone;

(9-Isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-[4-(1-methoxy-cyclobutanecarbonyl)1,4]diazepan-1-yl]-methanone;

2-Acetyl-9-ethoxy-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1 -α] isoquinoline-3-carboxylic acid ethyl ester;

1-[4-(2-Chloro-9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carbonyl)-[1,4]diazepan-1-ethanone;

4-Butyl-1-(9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]iso-quinoline-3-carbonyl)-[1,4]diazepan-5-one;

4-Butyl-1-[9-(2-hydroxy-2-methyl-propoxy)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-]isoquinoline-3-carbonyl]-[1,4]diazepan-5-one;

1-[5-(9-Isopropoxy-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carbonyl)-[ 1,5]diazocan- 1-yl]-ethanone;

7-(9-Isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] iso-quinoline-3-carbonyl) -3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester;

1-[7-(9-Isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carbonyl)-3,7-diaza-bicyclo[3.3.1]non-3-yl]-2-methylsulfanyl-ethanone;

9-(2-Hydroxy-ethoxy)-8-methoxy-1-thiophen-2-yl-pyrrolo[2,1 -α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

2-Formyl-9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

2-Hydroxymethyl-9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Isopropoxy-8-methoxy-2-methoxymethyl-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide:

2-(Hydroxyimino-methyl)-9-isopropoxy-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Isopropoxy-8-methoxy-2-(methoxyimino-methyl)-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Isopropylamino-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Methoxy-9-(1H-pyrazol-4-yl)-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;;

8-Methoxy-9-(2-methyl-propenyl)-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Isobutyl-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1 -α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Methoxy-9-(2-methyl-propenyl)-1-thiazol-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Hydroxy-9-isobutyl-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1 -α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

N—[3-(2,2-Dimethyl-pyrrolidine-1-carbonyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinolin-9-yl]-isobutyramide;

8-Methoxy-9-methylcarbamoylmethoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1 -α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(2-Hydroxy-ethoxy)-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] iso-quinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(2-Azido-ethoxy)-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Methoxy-9-(tetrahydro-pyran-2-yloxy)-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(3-Hydroxy-propoxy)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]iso-quinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Isobutyl-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-methyl-amide;

(9-Bromo-8-methoxy-1-thiophen-2-yl-5,6,6a, 10a-tetrahydro-pyrrolo[2,1-α]isoquinolin-3-yl)-(4-cyclobutanecarbonyl-[1,4]diazepan-1-yl)-methanone;

9-Cyano-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

3-(4-Cyclobutanecarbonyl-[1,4]diazepane-1-carbonyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-9-carboxylic acid ethyl ester;

8-Methoxy-9-prop-1-ynyl-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-Formyl-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(3-hydroxy-propyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] iso-quinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(3-Hydroxy-3-methyl-butyl)-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

(9-(2,2-Difluoro-vinyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide.;

8-Methoxy-9-nitro-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(2-Dimethylamino-acetylamino)-8-methoxy-1-thiophen-2-yl-5,6,6a,10a-tetrahydro-pyrrolo[2,1-α]isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

9-(2-Azetidin-1-yl-acetylamino)-8-methoxy-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Methoxy-9-(2-methoxy-acetylamino)-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

N—[3-(2,2-Dimethyl-pyrrolidine-1-carbonyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinolin-9-yl]-methanesulfonamide;

N—[3-(2,2-Dimethyl-pyrrolidine-1-carbonyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinolin-9-yl]-2-morpholin-4-yl-acetamide;

(8,9-Dimethoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinolin-3-yl)-[4-(1-methyl-cyclobutanecarbonyl)- [1,4] diazepan-1-yl] -methanone;

(4-Cyclobutanecarbonyl-[1,4]diazepan-1-yl)-(8,9-dimethoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinolin-3-yl)-methanone;

(4-Cyclobutanecarbonyl-[1,4]diazepan-1-yl)-(8,9-dimethoxy-1-thiophen-2-yl-pyrrolo[2,1 -α] isoquinolin-3-yl)-methanone;

9-Hydroxymethyl-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

8-Methoxy-9-methoxymethyl-l-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α] isoquinoline-3-carboxylic acid tert-butyl-methyl-amide;

1-[3-(2,2-Dimethyl-pyrrolidine-1-carbonyl)-8-methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinolin-9-yl]-ethanone; and

8-Methoxy-1-thiophen-2-yl-5,6-dihydro-pyrrolo[2,1-α]isoquinoline-3,9-dicarboxylic acid 3-(tert-butyl-methyl-amide) 9-[1,3,4]thiadiazol-2-yl-amide.

18. A pharmaceutical composition which comprises a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

19. A method of ovarian stimulation comprising administering a pharmaceutical composition according to claim 18 .

20. A method of treating a fertility disorder comprising administering a pharmaceutical composition according to claim 18 .