IP Library › Granted Patent US 8,188,247
Granted Patent B2
US 8,188,247 · App. 12/871,750 · Granted May 29, 2012

Conjugates and compositions for cellular delivery

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Quick Facts
Patent No.
US 8,188,247
App. No.
12/871,750
Granted
May 29, 2012
Kind
B2
Abstract

This invention features conjugates, compositions, methods of synthesis, and applications thereof, including folate derived conjugates of nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids and antisense nucleic acid molecules.

Claims (5)

1. A compound having the formula VI:

wherein each R 4 , R 5 , R 6 and R 7 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, or a protecting group, R 2 is a nucleic acid that is double stranded, each “n” is independently an integer from 0 to about 200, and L is :

each R 3 and R 4 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, or a protecting group and R 13 is an amino acid side chain.

2. The compound of claim 1 , wherein R 3 , R 4 , R 5 , R 6 and R 7 are hydrogen.

3. The compound of claim 1 wherein the nucleic acid is an enzymatic nucleic acid.