Topical compositions for inhibiting matrix metalloproteases and providing antioxidative activities
View Patent ↗A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.
1. A topical skin composition comprising:
(a) a soybean seed extract at a concentration of 0.1-0.9% by weight;
(b) a reaction product of acetic acid and a hexapeptide consisting of alanine, glycine, valine, and proline at a concentration of 0.125-1.125% by weight;
(c) apple fruit extract at a concentration of 0.4-3.6% by weight;
(d) cinnamon bark extract at a concentration of 0.1-0.9% by weight;
(e) Chinese rhubarb extract at a concentration of 0.1-0.9% by weight;
(f) snow fungus extract at a concentration of 0.042-0.378% by weight;
(g) clove extract at a concentration of 0.485-4.365% by weight; and
(h) green tea leaf extract at a concentration of 0.22-1.98% by weight.
2. A cosmetic product comprising, the composition of claim 1 at a concentration of 0.1-10% by weight.
3. A cosmetic product comprising the composition of claim 1 at a concentration of 1.0-8.0% by weight.
4. A cosmetic product comprising the composition of claim 1 at a concentration of 2.0-6% by weight.
5. A method for providing antioxidant and matrix metalloprotease inhibiting activities to the skin, comprising the steps of: topically applying the product of claim 2 .
6. A topical skin composition comprising:
(a) a soybean seed extract at a concentration of about 0.5% by weight;
(b) a reaction product of acetic acid and a hexapeptide consisting of alanine, glycine, valine, and proline at a concentration of about 0.625% by weight;
(c) apple fruit extract at a concentration of about 2.000% by weight;
(d) cinnamon bark extract at a concentration of about 0.500% by weight;
(e) Chinese rhubarb extract at a concentration of about 0.500% by weight;
(f) snow fungus extract at a concentration of about 0.210% by weight;
(g) clove extract at a concentration of about 2.425% by weight; and
(h) green tea leaf extract at a concentration of about 1.100% by weight.
7. A cosmetic product comprising the composition of claim 6 at a concentration of 0.1-10% by weight.
8. A cosmetic product comprising the composition of claim 6 at a concentration of 1.0-8.0% by weight.
9. A cosmetic product comprising the composition of claim 6 at a concentration of 2.0-6% by weight.
10. A method for providing antioxidant and matrix metalloprotease inhibiting activities to the skin, comprising the steps of: topically applying the composition of claim 6 .
11. A method for providing antioxidant and matrix metalloprotease inhibiting activities to the skin, comprising the steps of topically applying the product of claim 7 .