Solid pharmaceutical dosage form
View Patent ↗A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
1. A method of treating an HIV infection comprising administering a solid pharmaceutical dosage form to a mammal in need of such treatment, wherein the dosage form comprises:
ritonavir and lopinavir formulated in solid dispersion;
a copolymer of N-vinyl pyrrolidone and vinyl acetate; and
a sorbitan fatty acid ester having a HLB value of from 4 to 10.
2. The method of claim 1 , wherein said ritonavir and lopinavir are present in an amount from 5% to 30% by weight of the dosage form, said copolymer of N-vinyl pyrrolidone and vinyl acetate is present from 50% to 85% by weight of the dosage form; and said sorbitan fatty acid ester is present from 2% to 20% by weight of the dosage form.
3. The method of claim 1 , wherein said ritonavir and lopinavir are formulated in a solid dispersion which comprises said copolymer of N-vinyl pyrrolidone and vinyl acetate and said sorbitan fatty acid ester.
4. The method of claim 3 , wherein said copolymer of N-vinyl pyrrolidone and vinyl acetate is copovidone, and said sorbitan fatty acid ester is sorbitan monolaurate.
5. The method of claim 1 , wherein said ritonavir and lopinavir are formulated in a solid or glassy solution which comprises said copolymer of N-vinyl pyrrolidone and vinyl acetate and said sorbitan fatty acid ester.
6. The method of claim 5 , wherein said copolymer of N-vinyl pyrrolidone and vinyl acetate is copovidone, and said sorbitan fatty acid ester is sorbitan monolaurate.
7. The method of claim 1 , wherein said dosage form comprises at least one additive selected from flow regulators, disintegrants, bulking agents or lubricants.
8. A method of treating an HIV infection comprising administering a solid pharmaceutical dosage form to a patient in need of such treatment, wherein the dosage form comprises a solid dispersion which comprises:
ritonavir, and lopinavir,
a pharmaceutically acceptable surfactant having an HLB value of from 4 to 10, and
a pharmaceutically acceptable water-soluble polymer having a Tg of at least 50° C.
9. The method of claim 8 , wherein said solid dispersion is a glassy or solid solution.
10. The method of claim 9 , wherein said water-soluble polymer is a copolymer of N-vinyl pyrrolidone and vinyl acetate, and said surfactant is a sorbitan mono fatty acid ester.
11. The method of claim 9 , wherein said water-soluble polymer is copovidone, and said surfactant is sorbitan monolaurate.
12. The method of claim 11 , wherein said water-soluble polymer is present in an amount of from 50% to 85% by weight of the dosage form, and said surfactant is present in an amount of from 2% to 20% by weight of the dosage form.
13. The method of claim 12 , wherein said ritonavir and lopinavir are present in an amount of from 5% or 30% by weight of the dosage form.
14. The method of claim 8 , wherein said dosage form comprises at least one additive selected from flow regulators, disintegrants, bulking agents or lubricants.
15. The method of claim 8 , wherein the dosage form contains, upon storage for 6 weeks at 40° C. and 75% humidity, at least 98% of the initial content of ritonavir.
16. The method of claim 8 , wherein the dosage form has a dose-adjusted AUC, in dogs under non-fasting conditions, of ritonavir plasma concentration of at least 9 μg h/ml/100 mg, and a dose-adjusted AUC, in dogs under non-fasting conditions, of lopinavir plasma concentration of at least 20 μg h/ml/100 mg.
17. A method of treating an HIV infection comprising administering a solid pharmaceutical dosage form to a patient in need of such treatment, wherein the dosage form comprises a solid dispersion which comprises:
ritonavir and lopinavir;
a pharmaceutically acceptable surfactant which has an HLB value of from 4 to 10, or a combination of pharmaceutically acceptable surfactants which has an HLB value of from 4 to 10; and
a pharmaceutically acceptable water-soluble polymer having a Tg of at least 50° C., or a combination of pharmaceutically acceptable water-soluble polymers having a Tg of at least 50° C.
18. The method of claim 17 , wherein said solid dispersion is a solid solution or a glassy solution.