Collateral pathway treatment using agent entrained by aspiration flow current
View Patent ↗A method and system for increasing the flow resistance of collateral pathways in the lung by employing aspiration to establish an artificial convective flow current between compartments in the lung in order to entrain and deliver a clogging agent preferentially to the collateral pathways. The method may sometimes be performed after lung has been assessed for the presence of collateral pathways.
1. A method of regulating air flow for a targeted lung region comprising a segment or lobe of the lung, the method comprising:
selecting a patient having a collateral pathway in the lung;
providing a mixture comprising autologous blood into lung tissue over a period of time;
reducing collateral air flow that flows through the collateral pathway between the targeted lung region and another segment or lobe of the lung by injecting the mixture into the targeted lung region; and
after reducing collateral flow to the targeted lung region, reducing direct air flow in a bronchus that provides direct air flow to the targeted lung region.
2. The method of claim 1 , wherein the injecting comprises:
deploying a delivery catheter through a bronchial tree into the targeted lung region such that a distal end of the delivery catheter communicates with the targeted lung region;
flowing the mixture through the delivery catheter so that the mixture exits the distal end of the delivery catheter into the targeted lung region.
3. The method of claim 1 , wherein the mixture further comprises a sclerosing agent that induces a reaction that causes sclerosis in the lung tissue.
4. The method of claim 3 , wherein the sclerosing agent is selected from the group consisting of tetracycline, doxycycline, and minocycline.
5. The method of claim 1 , wherein reducing direct flow comprises implanting a flow control element which allows air flow in an exhalation direction and restricts air flow in an inspiration direction.
6. The method of claim 4 , wherein reducing direct flow comprises implanting a flow control element which allows air flow in an exhalation direction and restricts air flow in an inspiration direction.
7. The method of claim 1 , wherein the mixture further comprises a bulking agent, wherein the bulking agent is configured to cause the mixture to be released into tissue of the target lung region over a period of time.
8. The method of claim 1 , wherein the mixture further comprises radiographic contrast.