Methods of preparing imidazole-based compounds
View Patent ↗Methods of preparing imidazole-based compounds are disclosed. Particular compounds are of formula I.
1. A composition compising an alcohol and (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-ethanone oxime and (Z)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-ethanone oxime in an E:Z isomer ratio that is greater than 8:1.
2. The composition of claim 1 , wherein the E:Z isomer ratio is greater than 10:1.
3. The composition of claim 2 , wherein the E:Z isomer ratio is greater than 13:1.
4. The composition of claim 1 , wherein the alcohol is methanol, ethanol, propanol, or isopropanol.
5. The composition of claim 4 , wherein the alcohol is methanol.
6. The composition of claim 1 , which is acidic.
7. The composition of claim 6 , which is acidic due to the addition of an acid which is hydroiodic, hydrobromic, hydrochloric, sulfuric, nitric, phosphoric, alkanesulfonic, or arenesulfonic acid.
8. The composition of claim 7 , wherein the acid is hydrochloric acid.