Granted Patent
B2
US 8,268,844 · App. 12/885,936 · Granted Sep 18, 2012
Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-l-phenylalanine hydrochloride, production method thereof and use thereof
Assignee:
Ajinomoto Co., Inc.
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Abstract
Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride: are useful as α4 integrin inhibitors.
Claims (5)
1. A crystal of the hydrochloride salt of the compound of the formula (I):
wherein said crystal has peaks at the diffraction angles (2θ) 6.4°, 8.5°, 9.3°, 12.9°, 14.8°, and 15.3° in its powder X-ray diffraction pattern.
2. A crystal according to claim 1 , which has a 13C-NMR spectrum of FIG. 28 .
3. A crystal according to claim 1 , which has an infrared spectrum of FIG. 29 .
4. A pharmaceutical composition, which comprises a crystal according to claim 1 and a pharmaceutically acceptable carrier.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 21, 2016
From: AJINOMOTO CO., INC.
To: EA PHARMA CO., LTD.
Reel/Frame 039094/0087 →
Priority Claims (1)
JP 2005-181219
· Jun 21, 2005
· national
Continuity (3)
Continuation
PCTJP2006312432
· Jun 21, 2006