Composition of activated CD4 cells
The composition of activated CD4 cells is derived from a healthy human donor. The composition from the healthy human donor is suspended in an infusion media and packaged in a vehicle for administration to a subject to treat disease.
1. A composition of activated CD4 cells derived from a healthy human donor suspended in infusion media and packaged in a vehicle for administration to a subject to treat disease.
2. The composition of claim 1 where the CD4 cells are Th1 cells.
3. The composition of claim 1 wherein the CD4 cells are activated by crosslinking of CD3 and CD28.
4. The composition of claim 3 wherein the CD3 and CD28 cross linking is accomplished by using immobilized anti-CD3 and anti-CD28 mAbs.
5. The composition of claim 4 wherein the anti-CD3 and anti-CD28 mAbs are immobilized on nano- or micro-particles.
6. The composition of claim 5 wherein the nano- or micro particles are biodegradable.
7. The composition of claim 1 wherein the anti-CD3 and anti-CD28 mAbs are immobilized on particles less than 1 micron.
8. The composition of claim 7 wherein the particles are biodegradable.