SYSTEM AND METHOD FOR FACILITATING HEMOSTASIS WITH AN ABSORBABLE SPONGE
The present invention provides for a method and apparatus to provide hemostasis at a blood vessel puncture site, having a hemostasis material and a clot formation accelerator, wherein said clot formation accelerator is substantially dispersed throughout said hemostasis material.
1 . A method of forming a clot formation accelerator loaded hemostasis material, comprising:
dissolving gelatin granules in water to form a gelatin solution;
heating the gelatin solution;
cooling the gelatin solution;
adding a cross-linking agent to the cooled gelatin solution;
mixing a clot formation accelerator into the cross-linking agent and gelatin solution to form a mixture;
adding air to the mixture to form a foam hemostasis material matrix;
drying the foam hemostasis material matrix at a temperature above freezing to form the hemostasis material.
2 . The method of claim 1 , wherein the hemostasis material is formed without freezing the foam hemostasis material matrix prior to drying.
3 . The method of claim 1 , further comprising the step of adding a polysaccharide to the gelatin solution.
4 . The method of claim 3 , wherein the polysaccharide is chitosan.
5 . The method of claim 1 , wherein the clot formation accelerator is a thrombogenic agent.
6 . The method of claim 1 , wherein the cross-linking agent is formaldehyde.
7 . The method of claim 1 , wherein the clot formation accelerator is substantially dispersed throughout the hemostasis material.
8 . The method of claim 3 , wherein the polysaccharide is substantially dispersed throughout the hemostasis material.
9 . The method of claim 1 , wherein the cross-linking agent is substantially dispersed throughout the hemostasis material.
10 . A method of forming a clot formation accelerator loaded hemostasis material, comprising:
dissolving gelatin granules in water to form a gelatin solution;
heating the gelatin solution;
cooling the gelatin solution;
adding a cross-linking agent to the cooled gelatin solution;
mixing a clot formation accelerator into the cross-linking agent and gelatin solution to form a mixture;
adding heat to the mixture to form a gelatin solid;
drying the gelatin solid at a temperature above freezing to form the hemostasis material.
11 . The method of claim 10 , wherein the hemostasis material is formed without freezing the gelatin solid prior to drying.
12 . The method of claim 10 , wherein the clot formation accelerator is substantially dispersed throughout the hemostasis material.
13 . The method of claim 10 , wherein the cross-linking agent is substantially dispersed throughout the hemostasis material.
14 . The method of claim 10 , wherein the gelatin solid has a solid crystalline network.
15 . The method of claim 10 , wherein the cross-linking agent is formaldehyde.
16 . The method of claim 10 , further comprising the step of adding a polysaccharide to the gelatin solution.
17 . The method of claim 10 , wherein the clot formation accelerator is a thrombogenic agent.
18 . A method of forming a clot formation accelerator loaded hemostasis material, comprising:
mixing chitosan, gelatin, and water together to form a mixture;
mixing formaldehyde and sodium hydroxide together to form a solution;
adding the mixture to the solution;
heating the combined solution and mixture;
adding thrombin to the combined solution and mixture;
mixing the combined solution, mixture, and thrombin to obtain a gelatin foam;
heating the gelatin foam in an oven at 90° F. to form the hemostasis material.