Spot-on pesticide composition
View Patent ↗A spot-on pesticide composition for animals, specifically mammals, including dogs and cats, which composition comprises a combination of active components, including fipronil and a pyrethroid, and optionally an insect growth regulator, in doses and proportions which are parasiticidally effective against a variety of insects and pests, and in a formulation which is convenient for local application to the animal's skin, preferably localized over a small surface area.
1. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition comprising 8% to 11% (w/w) fipronil, 3% to 16% (w/w) cyphenothrin, and 60% to 80% (w/w) organic solvent.
2. The method of claim 1 , wherein the spot-on composition comprises 4% to 6% (w/w) of cyphenothrin.
3. The method of claim 1 , wherein the animal is a mammal.
4. The method of claim 3 , wherein the mammal comprises a dog or a cat.
5. The method of claim 1 , wherein the spot-on composition additionally comprises an insect growth regulator.
6. The method of claim 5 , wherein the insect growth regulator is present in the composition at a concentration of between 2% to 15% (w/w).
7. The method of claim 1 , wherein the spot-on composition additionally comprises 4% to 6% (w/w) of an antioxidant.
8. The method of claim 1 , wherein the composition provides at least 90% efficacy against insect and pest pupae for a period of at least 30 days following administration of the composition to the animal.
9. The method of claim 1 , wherein the composition is administered to the animal in a volume sufficient to deliver to the animal a dosage of cyphenothrin ranging from about 0.1 mg/kg to about 40 mg/kg.
10. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition comprising:
a. 8% to 11% (w/w) fipronil;
b. 4% to 6% (w/w) cyphenothrin;
c. 70% to 80% (w/w) organic solvent; and
d. 4% to 6% (w/w) antioxidant.
11. The method of claim 10 , wherein the organic solvent is diethylene glycol monoethyl ether.
12. The method of claim 10 , wherein the antioxidant is tocopherol nicotinate.
13. The method of claim 12 , wherein the organic solvent is diethylene glycol monoethyl ether.
14. The method of claim 12 , wherein the composition further comprises 2% to 15% (w/w) insect growth regulator.
15. The method of claim 14 , wherein the insect growth regulator comprises pyriproxyfen or S-methoprene.
16. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition comprising:
a. 8% to 11% (w/w) fipronil;
b. 4% to 6% (w/w) cyphenothrin;
c. 8% to 12% (w/w) S-methoprene;
d. 70% to 80% (w/w) organic solvent; and
e. 4% to 6% (w/w) antioxidant.
17. The method of claim 16 wherein the animal is a mammal.
18. The method of claim 17 wherein the mammal comprises a dog or a cat.
19. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition comprising:
a. 8% to 11% (w/w) fipronil;
b. 4% to 6% (w/w) cyphenothrin;
c. 3% to 5% (w/w) pyriproxyfen;
d. 70% to 80% (w/w) organic solvent; and
e. 4% to 6% (w/w) antioxidant.
20. A method of killing insect and pest pupae and adults on an animal, which method comprises administering a localized cutaneous application between the shoulders of the animal, a spot-on composition comprising:
a. 8% to 11% (w/w) fipronil;
b. 4% to 6% (w/w) cyphenothrin; and
c. 70% to 80% (w/w) diethylene glycol monoethyl ether.
21. The method of claim 20 , wherein the composition further comprises 3% to 5% (w/w) pyriproxyfen.
22. The method of claim 20 , wherein the composition further comprises 8% to 12% (w/w) S-methoprene.