Cyclic glycyl-2-allyl proline and its use in treatment of peripheral neuropathy
View Patent ↗Embodiments of this invention provide methods for therapeutic use of cyclic G-2-allylProline (cG-2-allylP) to treat peripheral neuropathies, including toxin-induced peripheral neuropathy and diabetic peripheral neuropathy as well as manufacture of medicaments including tablets, capsules, and other orally active compositions containing cG-2-allylP, as well as injectable solutions that are useful for treatment of such conditions.
1. A method for treating a peripheral neuropathy caused by diabetes or pyridoxine in a mammal in need thereof, comprising: administering to said mammal a pharmaceutically effective amount of the compound having the formula:
or a pharmaceutically acceptable salt or hydrate thereof, wherein
R 1 =allyl, R 2 ═R 3 ═R 4 ═R 5 ═H, X 1 ═NH, X 2 ═CH 2 , said compound being cyclic Glycyl-2-allylProline (cG-2-allylP)).
2. The method of claim 1 , wherein said compound is administered in an aqueous solution and one or more pharmaceutically acceptable excipients, additives, carriers or adjuvants.
3. The method of claim 1 , wherein said method further comprises administering the compound in a composition comprising one or more excipients, carriers, additives, adjuvants or binders in a tablet or capsule.
4. The method of claim 1 , wherein said cG-2-allylP is administered orally.
5. The method of claim 1 , wherein said cG-2-allylP is administered via a route selected from the group of oral, intraperitoneal, intravascular, peripheral circulation, subcutaneous, intraorbital, ophthalmic, intraspinal, intracisternal, topical, infusion, implant, aerosol, inhalation, scarification, intraperitoneal, intracapsular, intramuscular, intranasal, buccal, transdermal, pulmonary, rectal, and vaginal.
6. The method of claim 1 , wherein the amount of said compound has a lower limit of about 0.01 milligrams per kilogram mass of the mammal per day (mg/kg/day) and an upper limit of about 100 mg/kg/day.
7. The method of claim 1 , wherein said amount has a lower limit of about 3 mg/kg/day and an upper limit of about 30 mg/kg/day.
8. The method of claim 1 , wherein said peripheral neuropathy is a toxic neuropathy caused by pyridoxine.
9. The method of claim 1 , wherein said peripheral neuropathy is diabetic peripheral neuropathy.