Liquid and low melting coatings for stents
Stents with coatings comprising a combination of a restenosis inhibitor comprising an HMG-CoA reductase inhibitor and a carrier. Also provided are methods of coating stents with a combination of an HMG-CoA reductase inhibitor and a carrier. A preferred example of a restenosis inhibitor is cerivastatin. The stent coatings have been shown to release restenosis inhibitors in their active forms.
1. A method of coating a stent comprising:
providing a stent,
providing a coating composition comprising a biologically active component and a non-polymeric biodegradable carrier having a melting point of about 50° C. or less and a viscosity of from about 0.1 to about 15000 cP, and
applying the coating composition to the stent.
2. The method of claim 1 , further comprising the step of expanding the stent to an increased diameter before applying the coating composition to the stent.
3. The method of claim 1 , wherein the step of applying the coating composition comprises spraying or painting the coating composition onto the stent, or immersing the stent in the coating composition.
4. The method of claim 1 , wherein the biodegradable carrier has a melting point of from about 35° C. to about 45° C.
5. The method of claim 1 , wherein the biodegradable carrier is a liquid at body temperature.
6. The method of claim 1 , wherein the biodegradable carrier is hydrophobic.
7. The method of claim 1 , wherein the biologically active component comprises a HMG-CoA reductase inhibitor present in an amount from about 1 wt % to about 50 wt %, based on the total weight of the coating composition.
8. The method of claim 7 , wherein the HMG-CoA reductase inhibitor is selected from cerivastatin, atorvastatin, simvastatin, fluvastatin, lovastatin, and pravastatin.
9. The method of claim 7 , wherein the HMG-CoA reductase inhibitor is cerivastatin.
10. The method of claim 1 , wherein the biologically active component is capable of inhibiting restenosis.
11. The method of claim 10 , wherein the biologically active component is selected from paclitaxes and rapamycin.
12. The method of claim 1 , wherein the biologically active component is selected from paclitaxel, actinomycin D, rapamycin, cerivastatin, fluvastatin, simvastatin, lovastatin, atorvastatin, and pravastatin, and combinations thereof.