Thermo-mechanically controlled implants and methods of use
View Patent ↗An implant comprises a structure that may be implanted into tissue and that has a first material property at normal body temperature. The first material property is variable at elevated temperatures above normal body temperature. The implant also has a plurality of particles dispersed in the structure that are adapted to convert incident radiation into heat energy when irradiated with electromagnetic radiation. The particles are in thermal contact with the structure such that exposure of the particles to incident radiation raises the temperature of the structure thereby changing the first material property relative to the first material property at normal body temperature.
1. A method of controlling a material property of a stent, the method comprising:
providing a polymeric stent having a plurality of metallic nanoshells dispersed therein, wherein the nanoshells are covered with a metal selected from the group consisting of palladium, silver, platinum, and gold, and wherein the stent has a first material property when implanted in tissue at normal body temperature, the material property being variable at an elevated temperature above normal body temperature; and
exposing the stent to electromagnetic radiation in the range of about 800 nm to 1200 nm, the incident radiation being converted into heat energy via the plurality of nanoshells thus uniformly raising the temperature of the stent above normal body temperature, thereby changing the material property relative to the first material property wherein the material property is either:
(i) the ability of the stent to be plastically deformed such that the stent is not plastically deformable at normal body temperatures but is plastically deformable at an elevated temperature above normal body temperature or
(ii) the viscosity of the stent where the stent has a lower viscosity at an elevated temperature above normal body temperature.
2. The method of claim 1 , wherein the stent temperature is raised to a temperature In the range from about 38° C. to about 60° C.
3. The method of claim 1 , wherein exposing the stent to electromagnetic radiation comprises delivering electromagnetic radiation to the stent with a catheter.
4. The method of claim 1 , wherein exposing the stent to electromagnetic radiation comprises delivering the radiation until a desired temperature is obtained in the implant.
5. The method of claim 1 , wherein the stent is biodegradable.
6. The method of claim 1 , further comprising releasing a therapeutic agent from the stent in a controlled manner.
7. The method of claim 1 , wherein the metallic nanoshells are covered with gold.
8. The method of claim 1 , further comprising generating the electromagnetic radiation with a laser light source.