IP Library › Granted Patent US 8,460,672
Granted Patent B1
US 8,460,672 · App. 12/893,731 · Granted Jun 11, 2013

Mosaic protein and nucleic acid vaccines against hepatitis C virus

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Quick Facts
Patent No.
US 8,460,672
App. No.
12/893,731
Granted
Jun 11, 2013
Kind
B1
Abstract

The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.

Claims (5)

1. A multivalent HCV mosaic polypeptide composition comprising a set of polypeptides selected from the group consisting of the polypeptides of SEQ ID NOS: 42-44 and the polypeptides of SEQ ID NOS: 45-48.

2. The composition according to claim 1 , wherein one or more of the selected polypeptides are fragmented to present individual HCV proteins.

3. The composition according claim 1 , further comprising a pharmaceutically acceptable carrier.

4. The composition according to claim 1 , further comprising an adjuvant.

5. The composition according to claim 1 , further comprising a co-stimulatory molecule.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2018
From: LOS ALAMOS NATIONAL SECURITY, LLC
To: TRIAD NATIONAL SECURITY, LLC
Reel/Frame 047438/0511 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 1, 2011
From: YUSIM, KARINA; KORBER, BETTE T. M.; KUIKEN, CARLA L.; FISCHER, WILLIAM M.
To: LOS ALAMOS NATIONAL SECURITY, LLC
Reel/Frame 025730/0078 →
CONFIRMATORY LICENSE Recorded Dec 15, 2010
From: LOS ALAMOS NATIONAL SECURITY
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 025498/0034 →