Modulators of G protein-coupled receptor 88
View Patent ↗The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
1. A compound of formula (II)
or a pharmaceutically acceptable salt thereof, wherein
A is selected from pyrazinyl and pyridinyl;
R 1 is selected from:
wherein “ ” denotes the point of attachment to the parent molecular moiety;
R 3 is selected from C 4 alkyl and C 1 alkoxy-C 2 alkyl;
R 4 is hydrogen; or
R 3 and R 4 , together with the carbon atom to which they are attached, form a carbonyl group, or form a ring selected from C 5 cycloalkyl and tetrahydropyranyl;
R 6 is selected from hydrogen and halo; and
R 7 is selected from
C 5 alkynyl;
C 3 cycloalkyl;
C 4 cycloalkyl-C 1 alkoxy; and
phenyl optionally substituted with one substituent selected from C 3 alkoxy, C 1 alkoxy-C 1 alkyl, C 3 alkyl, and C 2 alkynyl, provided that when the phenyl is substituted the substituent is in the para position on the phenyl ring;
R 8 is selected from hydrogen; C 1 -C 3 alkyl; and halo; and
R 9 is selected from hydrogen; C 1 -C 3 alkyl; and halo.
2. A compound selected from
or a pharmaceutically acceptable salt thereof.
3. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
4. A method of modulating G protein-coupled receptor 88 in a mammal, comprising administering to the mammal a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
5. The method of claim 4 wherein the mammal is a human.
6. The method of claim 4 wherein the G protein-coupled receptor 88 is modulated in order to treat a neurological disorder.
7. The method of claim 6 wherein the G protein-coupled receptor 88 is modulated in order to treat a neurological disorder wherein the neurological disorder is selected from psychosis, cognitive deficits in schizophrenia, affective disorders, attention deficit hyperactivity disorders, bipolar disorder, drug addiction, Parkinson's disease, and Alzheimer's disease.