IP Library Granted Patent US 8,426,414
Granted Patent B2
US 8,426,414 · App. 12/897,004 · Granted Apr 23, 2013

Modulators of G protein-coupled receptor 88

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Quick Facts
Patent No.
US 8,426,414
App. No.
12/897,004
Granted
Apr 23, 2013
Kind
B2
Abstract

The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.

Claims (23)

1. A compound of formula (II)

or a pharmaceutically acceptable salt thereof, wherein

A is selected from pyrazinyl and pyridinyl;

R 1 is selected from:

wherein “ ” denotes the point of attachment to the parent molecular moiety;

R 3 is selected from C 4 alkyl and C 1 alkoxy-C 2 alkyl;

R 4 is hydrogen; or

R 3 and R 4 , together with the carbon atom to which they are attached, form a carbonyl group, or form a ring selected from C 5 cycloalkyl and tetrahydropyranyl;

R 6 is selected from hydrogen and halo; and

R 7 is selected from

C 5 alkynyl;

C 3 cycloalkyl;

C 4 cycloalkyl-C 1 alkoxy; and

phenyl optionally substituted with one substituent selected from C 3 alkoxy, C 1 alkoxy-C 1 alkyl, C 3 alkyl, and C 2 alkynyl, provided that when the phenyl is substituted the substituent is in the para position on the phenyl ring;

R 8 is selected from hydrogen; C 1 -C 3 alkyl; and halo; and

R 9 is selected from hydrogen; C 1 -C 3 alkyl; and halo.

2. A compound selected from

or a pharmaceutically acceptable salt thereof.

3. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

4. A method of modulating G protein-coupled receptor 88 in a mammal, comprising administering to the mammal a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

5. The method of claim 4 wherein the mammal is a human.

6. The method of claim 4 wherein the G protein-coupled receptor 88 is modulated in order to treat a neurological disorder.

7. The method of claim 6 wherein the G protein-coupled receptor 88 is modulated in order to treat a neurological disorder wherein the neurological disorder is selected from psychosis, cognitive deficits in schizophrenia, affective disorders, attention deficit hyperactivity disorders, bipolar disorder, drug addiction, Parkinson's disease, and Alzheimer's disease.

Assignments (3)
SECURITY INTEREST Recorded Mar 17, 2022
From: LEXICON PHARMACEUTICALS, INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 059432/0709 →
RELEASE OF SECURITY INTEREST Recorded Sep 14, 2020
From: BIOPHARMA CREDIT PLC
To: LEXICON PHARMACEUTICALS, INC.
Reel/Frame 053767/0445 →
SECURITY INTEREST Recorded Dec 20, 2017
From: LEXICON PHARMACEUTICALS, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 044958/0377 →