Bacteriophage-containing therapeutic agents
The present invention relates in its broadest aspect to combined phage/antibiotic therapy. More particularly, it relates to use of (i) one or more bacteriophages and (ii) one or more antibiotics in the manufacture of a combined product for simultaneous, separate or sequential administration of (i) and (ii) to treat a bacterial infection characterized by biofilm formation, for example an infection comprising or consisting of P. aeruginosa . Treatment in this context may be either therapeutic or prophylactic treatment. Also provided are deposited bacteriophages each exhibiting different strain specificity against P. aeruginosa and combinations of such bacteriophages, e.g. a panel of six deposited bacteriophages which was found to be effective against a high percentage of clinical isolates of P. aeruginosa from canine ear infections.
1. A panel of bacteriophage for suppressing a Pseudomonas aeruginosa bacterial infection characterized by a biofilm formation, wherein said panel comprises one or more bacteriophage selected from bacteriophage deposited under Accession Numbers NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178, NCIMB 41179, NCIMB 41180 or NCIMB 41181.
2. The panel of bacteriophage according to claim 1 , wherein said panel comprises one or more bacteriophage selected from bacteriophage deposited under Accession Numbers NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178 or NCIMB 41179.
3. The panel of bacteriophage according to claim 1 , wherein said panel comprises six or more bacteriophage wherein each of said bacteriophage is selected from a bacteriophage deposited under Accession Numbers NCIMB 41174, NCIMB 41175, NCIMB 41176, NCIMB 41177, NCIMB 41178, NCIMB 41179, NCIMB 41180 or NCIMB 41181.
4. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41174.
5. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41175.
6. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41176.
7. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41177.
8. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41178.
9. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41179.
10. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41180.
11. The panel of bacteriophage according to claim 1 , wherein said panel comprises the bacteriophage deposited under Accession Numbers NCIMB 41181.