Electrochemical sensor having symmetrically distributed analyte sensitive areas
View Patent ↗The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.
1. An electrochemical sensor for in vivo use, comprising:
a substrate;
a working electrode formed on or in the substrate and having multiple working electrode areas exposed for contact with a body fluid;
a second electrode formed on or in the substrate and having at least one second electrode area exposed for contact with a body fluid;
the working electrode exposed areas and the at least one second electrode exposed area forming an array extending along the sensor; and
the multiple working electrode areas and the at least one second electrode area comprising a symmetrical arrangement, wherein, when an AC signal is applied to the sensor, a symmetrical potential distribution is produced in which the potential on opposite sides of the array is substantially the same.
2. The electrochemical sensor of claim 1 , wherein the at least one second electrode area comprises multiple second electrode areas.
3. The electrochemical sensor of claim 2 , wherein the second electrode comprises a reference electrode and the multiple second electrode areas comprise reference electrode areas exposed for contact with body fluid, the electrochemical sensor further comprising a counter electrode formed on or in the substrate, the counter electrode comprising at least one counter electrode area exposed for contact with body fluid.
4. The electrochemical sensor of claim 3 , wherein the counter electrode comprises multiple counter electrode areas exposed for contact with a body fluid, wherein the multiple working electrode areas, the multiple counter electrode areas and multiple reference electrode areas are symmetrically arranged, wherein a symmetrical potential distribution is produced when an AC signal is applied to the sensor.
5. The electrochemical sensor of claim 4 , wherein at least one of the multiple reference electrode areas comprises a different material composition than the remaining reference electrode areas.
6. The electrochemical sensor of claim 5 , wherein the at least one of the multiple reference electrode areas comprises Ag/AgCl.
7. The electrochemical sensor of claim 6 , wherein the remaining reference electrode areas comprise non-corroding electrical conductors.
8. The electrochemical sensor of claim 1 , wherein the substrate is substantially planar.
9. The electrochemical sensor of claim 1 , wherein the working electrode areas are spaced along a lengthwise direction of the sensor.
10. An electrochemical sensor for testing a body fluid, comprising:
a substrate;
a working electrode formed on or in the substrate;
a counter electrode formed on or in the substrate;
a reference electrode formed on or in the substrate and having multiple spaced apart reference electrode areas that are exposed for contact with body fluid, wherein at least one of the multiple reference electrode areas comprises a different material composition than the remaining reference electrode areas.
11. The electrochemical sensor of claim 10 , wherein the at least one of the multiple reference electrode areas comprises Ag/AgCl.
12. The electrochemical sensor of claim 10 , wherein the remaining reference electrode areas comprise a non-corroding conductor.
13. The electrochemical sensor of claim 12 , wherein the non-corroding conductor comprises gold, platinum or carbon.
14. The electrochemical sensor of claim 10 , wherein the working electrode comprises multiple working electrode areas that are exposed for contact with a body fluid.
15. The electrochemical sensor of claim 14 , wherein the counter electrode comprises multiple counter electrode areas that are exposed for contact with a body fluid.
16. The electrochemical sensor of claim 15 , wherein the multiple working electrode areas, the multiple counter electrode areas and multiple reference electrode areas are arranged symmetrically, wherein a symmetrical potential distribution is produced when an AC signal is applied to the sensor.
17. An electrochemical sensor for in vivo use, comprising:
a substrate;
a working electrode formed on or in the substrate and having multiple working electrode areas exposed for contact with a body fluid;
a reference electrode formed on or in the substrate and having multiple reference electrode areas exposed for contact with a body fluid;
a counter electrode formed on or in the substrate and having at least one counter electrode area exposed for contact with a body fluid;
the multiple working electrode areas, the multiple reference electrode areas and the at least one counter electrode area being arranged symmetrically, wherein, when an AC signal is applied to the electrochemical sensor, a symmetrical potential distribution is produced in which the potential at all reference electrode areas exposed for contact with a body fluid is substantially the same.
18. The electrochemical sensor of claim 17 , wherein the at least one counter electrode area comprises multiple counter electrode areas, wherein the multiple working electrode areas, the multiple counter electrode areas and multiple reference electrode areas are arranged symmetrically, and wherein a symmetrical potential distribution is produced when an AC signal is applied to the sensor.
19. The electrochemical sensor of claim 18 , wherein the multiple working electrode areas, multiple reference electrode areas and multiple counter electrode areas are arranged spaced apart along a lengthwise direction of the sensor.
20. The electrochemical sensor of claim 19 , wherein the arrangement comprises an array of adjacent electrode areas arranged in the order of counter electrode area, then working electrode area, then reference electrode area.
21. The electrochemical sensor of claim 19 , wherein the arrangement comprises an array of adjacent electrode areas arranged in the order of counter electrode area, then working electrode area, then reference electrode area, then working electrode area, then counter electrode area.
22. The electrochemical sensor of claim 17 , wherein the multiple working electrode areas and multiple reference electrode areas are arranged spaced apart in an array along a lengthwise direction of the sensor.
23. The electrochemical sensor of claim 22 , wherein the at least one counter electrode area comprises an elongated member positioned adjacent to the array.
24. The electrochemical sensor of claim 17 , wherein at least one of the multiple reference electrode areas comprises a different material composition than the remaining reference electrode areas.
25. The electrochemical sensor of claim 24 , wherein the at least one of the multiple reference electrode areas comprises Ag/AgCl.
26. The electrochemical sensor of claim 25 , wherein the remaining reference electrode areas comprise a non-corroding conductor.
27. The electrochemical sensor of claim 17 , wherein the substrate is substantially planar.
28. The electrochemical sensor of claim 27 , wherein the working, counter and reference electrodes are formed as substantially flat conductors adhered to the substrate.
29. The electrochemical sensor of claim 28 , wherein the multiple working electrode areas comprises a conductive material overlying and in electrical contact with the working electrode.
30. The electrochemical sensor of claim 29 , further comprising at least one film disposed between the conductive material and the working electrode, the film having one or more openings to allow the electrical contact between the conductive material and the working electrode.