Methods of using a nitroxide antioxidant in cosmetic and dermatological compositions
View Patent ↗The present invention provides a dermatological and/or cosmetic composition which includes a methoxycinnamate, and a cyclic nitroxide. The present invention further provides a method of synthesizing photo absorbing-antioxidant compounds and their use in dermatological and/or cosmetic compositions. In addition, the present invention relates to the use of methoxycinnamate, and nitroxide compounds for the preparation of a composition for the dermatological and/or cosmetic treatment of skin.
1. A method of treating or preventing UV-induced photo-oxidative damage to skin comprising:
administering to the skin of an individual an effective amount of a composition comprising an excipient and compound of formula I:
where Z represents an oxygen; and R1, R2, R3, and R4 can be identical or different, each independently representing a hydrogen, an aryl, an alkyl, an alkenyl, an alkoxy;
wherein the composition is effective for treating or preventing UV-induced photo-oxidative damage to the skin.
2. The method of claim 1 , wherein the composition is applied topically.
3. The method of claim 2 , wherein the composition is in a form selected from the group consisting of a cream, lotion, powder, spray, gel, emulsion, mousse, aerosol, and combinations thereof.
4. A method of treating or preventing skin damage from the harmful effects of reactive oxygen species comprising administering a composition comprising a carrier and an effective amount of 2,2,6,6-tetramethyl-piperidin-4-yl-p-methoxy cinnamyloxy-1-oxyl (MC-NO) to an individual in need thereof.