Pyrrolo[2,3-D]pyrimidine compounds
View Patent ↗Described herein are pyrrolo[2,3-d]pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing these compounds, and methods for their preparation.
1. A compound of formula I
or a pharmaceutically acceptable salt thereof;
wherein the A ring is heterocyclyl;
wherein the A ring is optionally substituted with one or more substituents selected from the group consisting of halo, carboxy, cyano, oxo, aryl, heterocyclyl, (C 1 -C 8 )alkyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)OR 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —N(R 18 )S(O) 2 R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, cyano, aryl, heterocyclyl, —OR 23 , —OC(O)R 24 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SR 29 , —SO 2 R 30 , —SO 2 NR 31 R 32 , —N(R 33 )C(O)R 34 , and —N(R 35 )S(O) 2 R 36 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, heterocyclylcarbonyl(C 1 -C 6 )alkyl, and aminocarbonyl(C 1 -C 6 )alkyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 21 , R 22 , R 24 , R 25 , R 26 , R 27 , R 28 , R 31 , R 32 , R 33 , R 34 , R 35 and R 36 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 19 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkoxy;
R 20 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, aryl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
R 23 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, heterocyclyl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
R 29 is selected from the group consisting of hydrogen and heterocyclyl; and
R 30 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
wherein aryl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, cyano, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy;
wherein heterocyclyl, wherever it occurs, is optionally and independently substituted with one or more substituents selected from the group consisting of oxo, cyano, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkylaminocarbonyl, and (C 1 -C 6 )alkylsulfonyl(C 1 -C 6 )alkyl.
2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein the A ring is selected from the group consisting of optionally substituted piperidinyl, pyrrolidinyl, azetidinyl, and piperazinyl.
3. The compound of claim 2 or a pharmaceutically acceptable salt thereof, wherein the A ring is selected from the group consisting of piperidinyl, pyrrolidinyl, azetidinyl, and piperazinyl;
wherein the A ring is optionally substituted with one or more substituents selected from the group consisting of carboxy, cyano, oxo, fluoro, (C 1 -C 8 )alkyl, phenyl, oxadiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, pyrrolidinyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)OR 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —N(R 18 )S(O) 2 R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, cyano, phenyl, pyridinyl, piperazinyl, pyrazinyl, pyrazolyl, pyridazinyl, isoxazolyl, pyrimidinyl, pyrrolidinyl, —OR 23 , —OC(O)R 24 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SR 29 , —SO 2 R 30 , —SO 2 NR 31 R 32 , and —N(R 33 )C(O)R 34 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tert-butyl, aminocarbonylmethyl, ethoxyethyl, phenyl, and pyrrolidinylcarbonylmethyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 21 , R 22 , R 24 , R 25 , R 26 , R 27 , R 28 , R 31 , R 32 , R 33 and R 34 are independently selected from the group consisting of hydrogen, methyl, and ethyl;
R 19 is selected from the group consisting of hydrogen, tert-butoxy, trifluoromethyl, methoxy, and phenylmethoxy;
R 20 is selected from the group consisting of hydrogen, methyl, phenyl, benzyl, phenylethyl, and cyclopropylmethyl;
R 23 is selected from the group consisting of hydrogen, methyl, phenyl, pyridinylmethyl, and cyclopropylmethyl;
R 29 is selected from the group consisting of hydrogen and pyridinyl; and
R 30 is selected from the group consisting of hydrogen, methyl, propyl, and cyclopropylmethyl;
wherein phenyl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of fluoro, cyano, and methoxy;
wherein isoxazolyl, oxadiazolyl, pyridinyl, piperazinyl, and pyridazinyl, wherever they occur in the A ring substituents, the R 23 substituents and the R 29 substituents, are optionally and independently substituted with one or more substituents selected from the group consisting of oxo, cyano, methyl, ethyl, methylsulfonylmethyl, and cyclopropylaminocarbonyl.
4. A compound of formula Ia
or a pharmaceutically acceptable salt thereof;
wherein the A ring is selected from piperidinyl, pyrrolidinyl, azetidinyl, and piperazinyl;
wherein the A ring is optionally substituted with one or more substituents selected from the group consisting of halo, carboxy, cyano, oxo, aryl, heterocyclyl, (C 1 -C 8 )alkyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)OR 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —N(R 18 )S(O) 2 R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, cyano, aryl, heterocyclyl, —OR 23 , —OC(O)R 24 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SR 29 , —SO 2 R 30 , —SO 2 NR 31 R 32 , —N(R 33 )C(O)R 34 , and —N(R 35 )S(O) 2 R 36 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, aryl, (C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, heterocyclylcarbonyl(C 1 -C 6 )alkyl, and aminocarbonyl(C 1 -C 6 )alkyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 21 , R 22 , R 24 , R 25 , R 26 , R 27 , R 28 , R 31 , R 32 , R 33 , R 34 , R 35 and R 36 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 19 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkoxy, halo(C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkoxy;
R 20 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, aryl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
R 23 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, heterocyclyl(C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
R 29 is selected from the group consisting of hydrogen and heterocyclyl; and
R 30 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
wherein aryl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, cyano, (C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy;
wherein heterocyclyl, wherever it occurs in the A ring substituents, the R 23 substituents and the R 29 substituents, is optionally and independently substituted with one or more substituents selected from the group consisting of oxo, cyano, (C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkylaminocarbonyl, and (C 1 -C 6 )alkylsulfonyl(C 1 -C 6 )alkyl.
5. The compound of claim 4 or a pharmaceutically acceptable salt thereof,
wherein the A ring is optionally substituted with one or more substituents selected from the group consisting of carboxy, cyano, oxo, fluoro, (C 1 -C 8 )alkyl, phenyl, oxadiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, pyrrolidinyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)OR 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —N(R 18 )S(O) 2 R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, cyano, phenyl, pyridinyl, piperazinyl, pyrazinyl, pyrazolyl, pyridazinyl, isoxazolyl, pyrimidinyl, pyrrolidinyl, —OR 23 , —OC(O)R 24 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SR 29 , —SO 2 R 30 , —SO 2 NR 31 R 32 , and —N(R 33 )C(O)R 34 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, tert-butyl, aminocarbonylmethyl, ethoxyethyl, phenyl, and pyrrolidinylcarbonylmethyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 21 , R 22 , R 24 , R 25 , R 26 , R 27 , R 28 , R 31 , R 32 , R 33 , and R 34 are independently selected from the group consisting of hydrogen, methyl, and ethyl;
R 19 is selected from the group consisting of hydrogen, tert-butoxy, trifluoromethyl, methoxy, and phenylmethoxy;
R 20 is selected from the group consisting of hydrogen, methyl, phenyl, benzyl, phenylethyl, and cyclopropylmethyl;
R 23 is selected from the group consisting of hydrogen, methyl, phenyl, pyridinylmethyl, and cyclopropylmethyl;
R 29 is selected from the group consisting of hydrogen and pyridinyl; and
R 30 is selected from the group consisting of hydrogen, methyl, propyl, and cyclopropylmethyl;
wherein phenyl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of fluoro, cyano, and methoxy;
wherein isoxazolyl, oxadiazolyl, pyridinyl, piperazinyl, and pyridazinyl, wherever they occur in the A ring substituents, the R 23 substituents and the R 29 substituents, are optionally and independently substituted with one or more substituents selected from the group consisting of oxo, cyano, methyl, ethyl, methylsulfonylmethyl, and cyclopropylaminocarbonyl.
6. A compound of Formula II
or a pharmaceutically acceptable salt thereof;
wherein R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5a , and R 5b are independently selected from the group consisting of hydrogen, carboxy, cyano, halo, (C 1 -C 8 )alkyl, aryl, heterocyclyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 , and —N(R 18 )C(O)R 19 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, heterocyclyl, —OR 23 , —NR 25 R 26 , —C(O)NR 27 R 28 , —SO 2 R 30 , and —SO 2 NR 31 R 32 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, and aminocarbonyl(C 1 -C 6 )alkyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 25 , R 26 , R 27 , R 28 , R 31 , and R 32 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 19 is selected from the group consisting of hydrogen and aryl(C 1 -C 6 )alkoxy;
R 23 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl; and
R 30 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkyl;
wherein aryl, wherever it occurs, is optionally substituted with one or more halo;
wherein heterocyclyl, wherever is occurs, is optionally and independently substituted with one or more substituents selected from the group consisting of (C 1 -C 6 )alkyl and (C 1 -C 6 )alkylsulfonyl(C 1 -C 6 )alkyl.
7. The compound of claim 6 or a pharmaceutically acceptable salt thereof, wherein
R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5a , and R 5b are independently selected from the group consisting of hydrogen, fluoro, carboxy, cyano, (C 1 -C 8 )alkyl, phenyl, oxadiazolyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —C(O)R 13 , —C(O)NR 14 R 15 , —NR 16 R 17 and —N(R 18 )C(O)R 19 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of fluoro, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolidinyl, —OR 23 , —C(O)NR 27 R 28 , —SO 2 R 30 , and —SO 2 NR 31 R 32 ;
R 10 is selected from the group consisting of hydroxy and ethoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, methyl, ethyl, tert-butyl, isopropyl, and aminocarbonylmethyl;
R 12 , R 13 , R 14 , R 15 , R 16 , R 17 R 18 , R 27 , R 28 , R 31 , and R 32 are independently selected from the group consisting of hydrogen, methyl, and ethyl;
R 19 is selected from the group consisting of hydrogen and phenylmethoxy;
R 23 is selected from the group consisting of hydrogen, methyl, cyclopropylmethyl, and phenyl; and
R 30 is selected from the group consisting of hydrogen, methyl, propyl, and cyclopropylmethyl;
wherein phenyl, wherever it occurs, is optionally substituted with one or more fluoro;
wherein oxadiazolyl or pyridazinyl, wherever they occur, are optionally and independently substituted with one or more substituents selected from the group consisting of methyl and methylsulfonylmethyl.
8. The compound of claim 7 or a pharmaceutically acceptable salt thereof, wherein
R 1a , R 1b , R 5a , and R 5b are hydrogen;
R 2a and R 2b are independently selected from the group consisting of hydrogen, ethyl, methoxy, and benzyloxycarbonylamino;
R 3a and R 3b are independently selected from the group consisting of hydrogen, cyano, hydroxy, hydroxymethyl, hydroxypropyl, methyl, ethyl, methoxy, methoxymethyl, methoxyethyl, methylaminocarbonyl, diethylaminocarbonyl, amino, aminocarbonyl, aminocarbonylmethyl, phenyl, methylsulfonylmethyloxadiazolyl, pyrimidinylmethyl, cyclopropylmethoxymethyl, and cyclopropylmethylsulfonylmethyl; and
R 4a and R 4b are independently selected from the group consisting of hydrogen, hydroxy, carboxy, fluoro, trifluoromethyl, cyano, methyl, ethoxy, methylcarbonyl, methylsulfonylmethyl, dimethylaminosulfonylmethyl, propylsulfonylmethyl, hydroxymethyl, aminocarbonyl, aminocarbonylmethoxy, aminosulfonylmethyl, methyloxadiazolyl, pyridinylmethyl, pyrrolidinylmethyl, and fluorophenoxymethyl.
9. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein
R 1a , R 1b , R 5a , and R 5b are hydrogen;
R 2a and R 2b are selected from the group consisting of hydrogen, ethyl, methoxy, and benzyloxycarbonylamino;
R 3a and R 3b are selected from the group consisting of hydrogen, cyano, hydroxy, hydroxymethyl, hydroxypropyl, methyl, ethyl, methoxy, methoxymethyl, methoxyethyl, methylaminocarbonyl, diethylaminocarbonyl, amino, aminocarbonyl, aminocarbonylmethyl, phenyl,
R 4a and R 4b are selected from the group consisting of hydrogen, hydroxy, carboxy, fluoro, trifluoromethyl, cyano, methyl, ethoxy, methylcarbonyl, methylsulfonylmethyl, dimethylaminosulfonylmethyl, propylsulfonylmethyl, hydroxymethyl, aminocarbonyl, aminocarbonylmethoxy, aminosulfonylmethyl,
10. The compound of claim 6 or a pharmaceutically acceptable salt thereof, wherein
R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5a , and R 5b are independently selected from the group consisting of (C 1 -C 8 )alkyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , and —C(O)NR 14 R 15 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with —OR 23 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 1 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl;
R 12 , R 14 , and R 15 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 23 is selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl.
11. A compound of Formula III
or a pharmaceutically acceptable salt thereof; wherein
R 6a , R 6b , R 7a , R 7b , R 8a , R 8b , R 9a , and R 9b are independently selected from the group consisting of hydrogen, cyano, halo, (C 1 -C 8 )alkyl, aryl, heterocyclyl, —OP(O)(R 10 ) n , —OR 11 , —OC(O)R 12 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of cyano, aryl, heterocyclyl, —OR 23 , NR 25 R 26 , and —SR 29 ;
R 10 is selected from the group consisting of hydroxy and (C 1 -C 6 )alkoxy;
n is one or two;
R 11 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, halo(C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylaminocarbonyl(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl(C 1 -C 6 )alkyl, aminocarbonyl(C 1 -C 6 )alkyl, and heterocyclylcarbonyl(C 1 -C 6 )alkyl;
R 12 , R 16 , R 17 , R 18 , R 21 , R 22 , R 25 , and R 26 are independently selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 19 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkoxy, and halo(C 1 -C 6 )alkyl;
R 20 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, and aryl(C 1 -C 6 )alkyl;
R 23 is selected from the group consisting of hydrogen, (C 1 -C 6 )alkyl, aryl, and heterocyclyl-(C 1 -C 6 )alkyl; and
R 29 is selected from the group consisting of hydrogen and heterocyclyl;
wherein aryl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of halo, (C 1 -C 6 )alkoxy, and cyano;
wherein heterocyclyl, wherever it occurs, is optionally and independently substituted with one or more substituents selected from the group consisting of (C 1 -C 6 )alkyl and oxo.
12. The compound of claim 11 or a pharmaceutically acceptable salt thereof, wherein
R 6a , R 6b , R 7a , R 7b , R 8a , R 8b , R 9a , and R 9b are independently selected from the group consisting of hydrogen, cyano, fluoro, (C 1 -C 8 )alkyl, phenyl, pyridinyl, pyrimidinyl, —OR 11 , —OC(O)R 12 , —NR 16 R 17 , —N(R 18 )C(O)R 19 , —SO 2 R 20 , and —SO 2 NR 21 R 22 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with one or more substituents selected from the group consisting of cyano, phenyl, isoxazolyl, piperazinyl, pyrazinyl, pyrazolyl, pyridinyl, pyrrolidinyl, —OR 23 , —NR 25 R 26 , and —SR 29 ;
R 11 is selected from the group consisting of hydrogen, methyl, tert-butyl, isopropyl, ethoxyethyl, phenyl, and pyrrolidinylcarbonylmethyl;
R 12 , R 16 , R 17 , R 18 , R 21 , R 22 , R 25 , and R 26 are independently selected from the group consisting of hydrogen, methyl, and ethyl;
R 19 is selected from the group consisting of hydrogen, tert-butoxy, and trifluoromethyl;
R 20 selected from the group consisting of hydrogen, methyl, benzyl, and phenylethyl;
R 23 is selected from the group consisting of hydrogen, methyl, phenyl, and pyridinylmethyl; and
R 29 is selected from the group consisting of hydrogen and pyridinyl;
wherein phenyl, wherever it occurs, is optionally substituted with one or more substituents independently selected from the group consisting of fluoro and methoxy;
wherein isoxazolyl, pyridinyl, or piperazinyl, wherever they occur, are optionally and independently substituted with one or more substituents selected from the group consisting of oxo, methyl, and ethyl.
13. The compound of claim 12 or a pharmaceutically acceptable salt thereof, wherein
R 6a , R 6b , and R 9b are hydrogen;
R 7a and R 7b are independently selected from the group consisting of hydrogen, fluoro, hydroxy, cyano, methyl, methoxy, methoxymethyl, hydroxymethyl, phenyl, pyridinyl, and
R 8a and R 8b are independently selected from the group consisting of hydrogen, fluoro, hydroxy, amino, ethylaminoethyl, ethoxyethoxy, methylaminosulfonyl, methylsulfonyl, trifluoromethylcarbonylamino, hydroxymethyl, cyanomethyl, phenyl, benzyl, fluorophenyl, pyrimidinyl, pyridinyl, methylisoxazolylethyl, pyrazolylmethyl, benzylsulfonyl, benzylmethylsulfonyl, methoxybenzylsulfonyl, pyridinylthiomethyl, fluorophenoxymethyl, pyridinylmethoxymethyl, ethylpyridinylmethoxymethyl, pyrrolidinylcarbonylmethoxy,
and
R 9a is selected from the group consisting of hydrogen, methyl, methoxymethyl, hydroxymethyl, and methylpylypyryl.
14. The compound of claim 13 or a pharmaceutically acceptable salt thereof, wherein
R 6a , R 6b , and R 9b are hydrogen;
R 7a and R 7b are independently selected from the group consisting of hydrogen, fluoro, hydroxy, cyano, methyl, methoxy, methoxymethyl, hydroxymethyl, phenyl,
R 8a and R 8b are independently selected from the group consisting of hydrogen, fluoro, hydroxy, amino, ethylaminoethyl, ethoxyethoxy, methylaminosulfonyl, methylsulfonyl, trifluoromethylcarbonylamino, hydroxymethyl, cyanomethyl, phenyl, benzyl,
and
R 9a is selected from the group consisting of hydrogen, methyl, methoxymethyl, and hydroxymethyl.
15. The compound of claim 11 or a pharmaceutically acceptable salt thereof, wherein
R 6a , R 6b , R 7a , R 7b , R 8a , R 8b , R 9a , and R 9b are independently selected from the group consisting of halo, (C 1 -C 8 )alkyl, —OR 11 , and —N(R 18 )C(O)R 19 ; wherein the (C 1 -C 8 )alkyl is optionally substituted with —OR 23 ;
R 11 is selected from the group consisting of hydrogen and (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl;
R 18 is selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl;
R 19 is selected from the group consisting of hydrogen and (C 1 -C 6 )alkoxy; and
R 23 is selected from the group consisting of hydrogen and (C 1 -C 6 )alkyl.
16. A compound of Formula IV
or a pharmaceutically acceptable salt thereof; wherein R 37a , R 37b , R 38a , R 38b , R 39a and R 39b are selected from the group consisting of hydrogen, halo, hydroxy, heterocyclyl, (C 3 -C 8 )cycloalkyl(C 1 -C 6 )alkylsulfonyl, arylsulfonyl, and (C 1 -C 6 )alkoxycarbonylamino.
17. The compound of claim 16 or a pharmaceutically acceptable salt thereof, wherein
R 37a , R 37b , R 38a , R 38b , R 39a and R 39b are independently selected from the group consisting of hydrogen, hydroxy, fluoro, pyrimidinyl, pyridinyl, tetrazolyl, cyclopropylmethylsulfonyl, phenylsulfonyl, and methoxycarbonylamino.
18. The compound of claim 17 or a pharmaceutically acceptable salt thereof, wherein
R 37a , R 37b , R 38b , R 39a , and R 39b are hydrogen; and
R 38a is selected from the group consisting of hydrogen, fluoro, hydroxy, methoxycarbonylamino, cyclopropylmethylsulfonyl, phenylsulfonyl, pyrimidinyl, pyridinyl, and tetrazolyl.
19. The compound of claim 18 or a pharmaceutically acceptable salt thereof, wherein
R 37a , R 37b , R 38b , R 39a , and R 39b are hydrogen; and
R 38a is selected from the group consisting of hydrogen, fluoro, hydroxy, methoxycarbonylamino,
20. A compound of Formula V
or a pharmaceutically acceptable salt thereof;
wherein R 40 , R 41 , R 42 , R 43 , and R 44 are independently selected from the group consisting of hydrogen, (C 1 -C 8 )alkyl, heterocyclyl, and heterocyclyl(C 1 -C 6 )alkyl; and
wherein heterocyclyl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of cyano, (C 1 -C 6 )alkyl, and (C 3 -C 8 )cycloalkylaminocarbonyl.
21. The compound of claim 20 or a pharmaceutically acceptable salt thereof,
wherein R 40 , R 41 , R 42 , R 43 , and R 44 are independently selected from the group consisting of hydrogen, methyl, pyridinyl, and pyridinylmethyl; and
wherein pyridinyl, wherever it occurs, is optionally substituted with one or more substituents selected from the group consisting of cyano, methyl, and cyclopropylaminocarbonyl.
22. The compound of claim 21 or a pharmaceutically acceptable salt thereof, wherein
R 40 , R 41 , and R 43 are hydrogen;
R 42 is selected from the group consisting of methyl, pyridinyl, pyridinylmethyl, methylpyridinyl, cyanopyridinyl, and cyclopropylaminocarbonylpyridinyl; and
R 44 is selected from the group consisting of hydrogen and methyl.
23. The compound of claim 22 or a pharmaceutically acceptable salt thereof, wherein
R 40 , R 41 , and R 43 are hydrogen;
R 42 is selected from the group consisting of methyl,
and
R 44 is selected from the group consisting of hydrogen and methyl.
24. A compound or pharmaceutically acceptable salt thereof, having the structure:
25. The compound of claim 1 , wherein the compound is selected from the group consisting of:
N-(trans-4-{[(3-methoxypiperidin-1-yl)sulfonyl]methyl}cyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methyl)-sulfonyl]piperidin-3-ol;
(3R)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]piperidin-3-ol;
(3R)-1-[({(1S,3R,4S)-3-methyl-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)sulfonyl]piperidin-3-ol;
trans-(R)-1-((4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-methylsulfonyl)piperidin-3-yl pivalate;
(3S)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]-piperidin-3-ol;
Diethyl (3R)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)sulfonyl]piperidin-3-yl phosphate;
N-[trans-4-({[3-(2-methoxyethoxy)piperidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
N-(trans-4-{[(3-isobutoxypiperidin-1-yl)sulfonyl]methyl}cyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
N-(trans-4-{[(3-ethoxypiperidin-1-yl)sulfonyl]methyl}cyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
{1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methyl)-sulfonyl]piperidin-3-yl}methanol;
N-[trans-4-({[4-(methoxymethyl)piperidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
(1-((Trans-4-(methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-methylsulfonyl)piperidin-4-yl)methanol;
(3S)-1-[({(1S,3R,4S)-3-methyl-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)sulfonyl]piperidin-3-ol;
(3R,4R)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]piperidine-3,4-diol;
1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}methyl)-sulfonyl]piperidin-4-ol;
(3R,4S)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]piperidine-3,4-diol;
4-(2-methoxyethyl)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)sulfonyl]piperidine-4-carboxamide;
N-(trans-4-{[(4-methoxypiperidin-1-yl)sulfonyl]methyl}cyclohexyl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
(R)-1-(trans-4-(methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-methylsulfonyl)-pyrrolidin-3-ol;
{(3r,4r)-4-methyl-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)-sulfonyl]pyrrolidin-3-yl}methanol;
{(3R,4R)-4-methyl-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)-sulfonyl]pyrrolidin-3-yl}methanol;
3-methyl-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]-pyrrolidin-3-ol;
(3R,4S)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]-pyrrolidine-3,4-diol;
N-[trans-4-({[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
((3S)-1-((3-methyl-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)-methylsulfonyl)-pyrrolidin-3-yl)methanol;
(3R,4R)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]-pyrrolidine-3,4-diol;
N-[trans-4-({[(3R)-3-(2-ethoxyethoxy)pyrrolidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
3-methyl-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexyl}-methyl)sulfonyl]-pyrrolidin-3-ol;
tert-butyl {(3S)-1-[({trans-4-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-cyclohexyl}methyl)-sulfonyl]pyrrolidin-3-yl}carbamate;
N-[trans-4-({[(3R,4R)-3,4-difluoropyrrolidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine;
N-[trans-4-({[3-(methoxymethyl)pyrrolidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; and
N-[trans-4-({[(3R)-3-methoxypyrrolidin-1-yl]sulfonyl}methyl)cyclohexyl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; or
a pharmaceutically acceptable salt thereof.
26. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
27. A pharmaceutical composition comprising a compound of claim 4 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
28. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof, having the structure:
, and a pharmaceutically acceptable carrier.