Imidazopyridines as a novel scaffold for multi-targeted kinase inhibition

1. A compound having Formula I

or a pharmaceutically acceptable salt thereof, wherein

W is alkyl, H, F, Cl, Br or I;

X is C(O)R 1 , C(O)NHR 1A , C(O)N(R 1 ) 2 , NHC(O)R 1A , NR 1 C(O)R 1 , NHC(O)NHR 1 , NHC(O)N(R 1 ) 2 , or NR 1 C(O)N(R 1 ) 2 ;

wherein R 1 is R 2 , R 3 , R 4 or R 5 ;

R 2 is aryl;

R 3 is heteroaryl;

R 4 is cycloalkyl, cycloalkenyl, or heterocyclyl;

R 5 is C1-C6 alkyl; each of which is unsubstituted or substituted with one or two independently selected R 6 , NH 2 or CN;

R 6 is R 7 , R 8 , or R 9 ;

R 7 is aryl;

R 8 is heteroaryl;

R 9 is cycloalkyl, cycloalkenyl, or heterocyclyl;

wherein R 1A is R 2A , R 3A , R 4A or R 5A ;

R 2A is aryl;

R 3A is heteroaryl;

R 4A is cycloalkyl, cycloalkenyl, or heterocyclyl;

R 5A is C1-C6 alkyl; each of which is unsubstituted or substituted with one or two independently selected R 6A , NH 2 or CN;

R 6A is R 7A ; R 8A ; or R 9A ;

R 7A is aryl;

R 8A is heteroaryl;

R 9A is cycloalkyl, cycloalkenyl, or heterocyclyl;

wherein the moieties represented by R 2 , R 3 , R 4 , R 7 , R 8 , R 9 , R 3A , R 4A , R 7A , R 8A , and R 9A are independently unsubstituted or substituted with one or two or three or four of independently selected, R 10 , OR 10 , SR 10 , S(O)R 10 , SO 2 R 10 , NH 2 , NHR 10 , N(R 10 ) 2 , C(O)R 10 , C(O)OR 10 , C(O)NH 2 , C(O)NHR 10 , C(O)N(R 10 ) 2 , C(NOH)NH 2 , NHC(O)R 10 , NR 10 C(O)R 10 , NHSO 2 R 10 , NR 10 SO 2 R 10 , NHC(O)OR 10 , NR 10 C(O)OR 10 , NHSO 2 NH 2 , NHSO 2 NHR 10 , NHSO 2 N(R 10 ) 2 , SO 2 NH 2 , SO 2 NHR 10 , SO 2 N(R 10 ) 2 , NHC(O)NH 2 , NHC(O)NHR 10 , NHC(O)N(R 10 ) 2 , NR 10 C(O)N(R 10 ) 2 , NO 2 , OH, (O), C(O)H, C(O)OH, CN, CF 3 , OCF 3 , CF 2 CF 3 , F, Cl, Br or I;

wherein the moiety represented by R 2A is independently unsubstituted or substituted with one or two or three or four of independently selected, R 10 , OR 10 , SR 10 , S(O)R 10 , SO 2 R 10 , NH 2 , NHR 10 , N(R 10 ) 2 , C(O)R 10 , C(O)OR 10 , C(O)NH 2 , C(O)NHR 10 , C(O)N(R 10 ) 2 , C(NOH)NH 2 , NHC(O)R 10 , NR 10 C(O)R 10 , NHSO 2 R 10 , NR 10 SO 2 R 10 , NHC(O)OR 10 , NR 10 C(O)OR 10 , NHSO 2 NH 2 , NHSO 2 NHR 10 , NHSO 2 N(R 10 ) 2 , SO 2 NH 2 , SO 2 NHR 10 , SO 2 N(R 10 ) 2 , NHC(O)NH 2 , NHC(O)NHR 10 , NHC(O)N(R 10 ) 2 , NR 10 C(O)N(R 10 ) 2 , NO 2 , OH, (O), C(O)H, C(O)OH, CN, CF 3 , OCF 3 , or CF 2 CF 3 ;

R 10 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl;

Y is R 12 or R 13 ;

R 12 is aryl;

R 13 is heteroaryl;

Z is alkyl, H, CF 3 , F, Cl, Br or I;

wherein the moieties represented by R 12 and R 13 are independently unsubstituted or substituted with one or two or three or four of independently selected, R 14 , OR 14 , SR 14 , S(O)R 14 , SO 2 R 14 , NH 2 , NHR 14 , N(R 14 ) 2 , C(O)R 14 , C(O)OR 14 , C(O)NH 2 , C(O)NHR 14 , C(O)N(R 14 ) 2 , C(NOH)NH 2 , NHC(O)R 14 , NR 14 C(O)R 14 , NHSO 2 R 14 , NR 14 SO 2 R 14 , NHC(O)OR 14 , NR 14 C(O)OR 14 , NHSO 2 NH 2 , NHSO 2 NHR 14 , NHSO 2 N(R 14 ) 2 , SO 2 NH 2 , SO 2 NHR 14 , SO 2 N(R 14 ) 2 , NHC(O)NH 2 , NHC(O)NHR 14 , NHC(O)N(R 14 ) 2 , NR 14 C(O)N(R 14 ) 2 , NO 2 , OH, (O), C(O)H, C(O)OH, CN, CF 3 , OCF 3 , CF 2 CF 3 , F, Cl, Br or I;

wherein each R 14 is R 15 , R 16 , R 17 or R 18 ;

R 15 is aryl;

R 16 is heteroaryl;

R 17 is cycloalkyl, cycloalkenyl, or heterocyclyl;

R 18 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R 19 , OR 19 , SR 19 , S(O) 2 R 19 , NHS(O) 2 R 19 , C(O)OH, NH 2 , NHR 19 , N(R 19 ) 2 , C(O)R 19 , C(O)OR 19 , C(O)NH 2 , C(O)NHR 19 , C(O)N(R 19 ) 2 , NHC(O)R 19 , NR 19 C(O)R 19 , NHC(O)OR 19 , NR 19 C(O)OR 19 , OH, F, Cl, Br or I;

wherein each R 19 is R 20 or R 21 ;

R 20 is aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl;

R 21 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R 22 , OR 22 , C(O)OH, NH 2 , NHR 22 , N(R 22 ) 2 , C(O)R 22 , C(O)NH 2 , C(O)NHR 22 , C(O)N(R 22 ) 2 , NHC(O)R 22 , NR 22 C(O)R 22 , OH, F, Cl, Br or I;

wherein each R 22 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, or heterocyclyl;

wherein the moieties represented by R 15 , R 16 , R 17 , and R 20 are independently unsubstituted or substituted with one or two or three or four of independently selected R 23 , OR 23 , SR 23 , S(O)R 23 SO 2 R 23 , C(O)R 23 , CO(O)R 23 , OC(O)R 23 , OC(O)OR 23 , NH 2 , NHR 23 , N(R 23 ) 2 , NHC(O)R 23 , NR 23 C(O)R 23 , NHS(O) 2 R 23 , NR 23 S(O) 2 R 23 , NHC(O)OR 23 , NR 23 C(O)OR 23 , NHC(O)NH 2 , NHC(O)NHR 23 , NHC(O)N(R 23 ) 2 , NR 23 C(O)NHR 23 , NR 23 C(O)N(R 23 ) 2 , C(O)NH 2 , C(O)NHR 23 , C(O)N(R 23 ) 2 , C(O)NHOH, C(O)NHOR 23 , C(O)NHSO 2 R 23 , C(O)NR 23 SO 2 R 23 , SO 2 NH 2 , SO 2 NHR 23 , SO 2 N(R 23 ) 2 , C(O)H, C(O)OH, C(N)NH 2 , C(N)NHR 23 , C(N)N(R 23 ) 2 , CNOH, CNOCH 3 , OH, (O), CN, N 3 , NO 2 , CF 3 , CF 2 CF 3 , OCF 3 , OCF 2 CF 3 , F, Cl, Br or I;

wherein each R 23 is R 24 , R 25 , R 26 , R 27 or R 28 ;

R 24 is spirocycloalkyl or spiroheterocycloalkyl;

R 25 is aryl;

R 26 is heteroaryl;

R 27 is cycloalkyl, cycloalkenyl, or heterocyclyl;

R 28 is alkyl, alkenyl or alkynyl; each of which is unsubstituted or substituted with one or two of independently selected R 29 , OR 29 , SR 29 , S(O) 2 R 29 , C(O)OH, NH 2 , NHR 29 N(R 29 ) 2 , C(O)R 29 , C(O)NH 2 , C(O)NHR 29 , C(O)N(R 29 ) 2 , NHC(O)R 29 , NR 29 C(O)R 29 , NHC(O)OR 29 , NR 29 C(O)OR 29 , NHS(O) 2 R 29 , NR 29 S(O) 2 R 29 , OH, (O), F, Cl, Br or I;

wherein each R 29 is alkyl, alkenyl or alkynyl each of which is unsubstituted or substituted with one or two of independently selected F, Cl, Br or I;

wherein the moieties represented by R 24 , R 25 , R 26 , and R 27 are independently unsubstituted or substituted with one or two of independently selected R 30 , OR + , C(O)R 30 , C(O)OR 30 , OH, (O), C(O)OH, CN, CF 3 , OCF 3 , CF 2 CF 3 , F, Cl, Br or I; and

R 30 is alkyl alkenyl, or alkynyl.

2. The compound of claim 1 wherein

X is C(O)R 1 , NHC(O)NHR 1 , NHC(O)N(R 1 ) 2 , or NR 1 C(O)N(R 1 ) 2 .

3. A compound according to claim 1 selected from

2,6-difluoro-N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-phenylurea;

2,6-difluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-phenylurea;

N-benzyl-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-(2,6-difluorophenyl)-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-(2-methylphenyl)-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-(2-chlorophenyl)-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-(4-fluorophenyl)-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-(3-methoxyphenyl)-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]cyclopropanecarboxamide;

N-isopropyl-N′-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

2,6-difluoro-N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-fluoro-N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl)}-2-phenylacetamide;

N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl)}-N′-phenylurea;

N-(2-fluorophenyl)-N′-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}urea;

N-(2,6-difluorophenyl)-N′-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}urea;

2-(2-fluorophenyl)-N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

2-(2,6-difluorophenyl)-N-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

N-benzyl-N′-{3-[3-(2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}urea;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-fluorobenzamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-(2,6-difluorophenyl)-N′-(3-{3-[2-({3-[(dimethylamino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-[3-(8-chloro-3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(8-chloro-3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(8-chloro-3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-[3-(8-chloro-3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-phenylurea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-[3-(3-{2-[(3-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(3-{2-[(3-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-[3-(3-{2-[(3-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-5-methylthiophene-2-carboxamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-5-methylthiophene-2-carboxamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-{3-[3-(2-{[3-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-phenyl-N-{3-[3-(2-{[3-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

N-{3-[3-(2-{[3-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({3-[(3-hydroxyazetidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(3-hydroxyazetidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[(3-hydroxyazetidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-[3-(3-{2-[(3-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-[3-(3-{2-[(3-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(3-{2-[(3-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(1-acetylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(1-acetylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-[3-(3-{2-[(3-cyanophenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(3-{2-[(3-cyanophenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-cyanophenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({3-[2-(methylsulfonyl)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[2-(methylsulfonyl)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(methylsulfonyl)ethoxy]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-{3-[3-(2-{[4-(1-isopropylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[4-(1-isopropylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[(Z)-amino(hydroxyimino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[(Z)-amino(hydroxyimino)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(2-amino-2-oxoethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-(2-{[3-(2-amino-2-oxoethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(2-amino-2-oxoethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

isopropyl (3-{[4-(2-{3-[(phenylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)acetate;

N-{3-[3-(2-{[4-(1-ethylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(1-ethylpiperidin-4-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-(2-{[4-(1-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-(1-methyl-1H-imidazol-4-yl)acetamide;

2,5-difluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

3,5-difluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2,3-difluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-3-ylacetamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-(3-methylisoxazol-5-ylacetamide;

N-[3-(3-{2-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(3-{2-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(1-acetyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2,4-difluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-chloro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-fluoro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-{3-[3-(2-{[4-(1-ethylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(1-ethylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(1-acetylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(1-acetylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(1-acetylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-[3-(3-{2-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-[3-(3-{2-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

N-[3-(3-{2-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

2,6-difluoro-N-methyl-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2,6-difluoro-N-{3-[3-(2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

4-methyl-N-{3-[3-(2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

2-phenyl-N-{3-[3-(2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

N-{3-[3-(2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

5-methyl-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

4-methyl-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

2,5-dichloro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-3-carboxamide;

5-chloro-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

3-methyl-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-1-benzothiophene-2-carboxamide;

N-{3-[3-(2-{[2-(methoxyacetyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(1-acetylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-(2-{[2-(3-methoxypropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-3-carboxamide;

N-(2-fluorophenyl)-3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)benzamide;

3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)-N-(thien-2-ylmethyl)benzamide;

2-chloro-N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-chloro-N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-6-fluorobenzamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-(5-methylthien-2-yl)acetamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-(2-methyl-1,3-thiazol-5-yl)acetamide;

N-{3-[3-(2-{[4-(4-isopropylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(4-isopropylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

2,6-difluoro-N-{3-[3-(2-{[4-(4-isopropylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-chloro-N-{3-[3-(2-{[4-(4-isopropylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-[3-(3-{2-[(1-methyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

2-phenyl-N-{3-[3-(2-{[3-(pyrrolidin-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

N-{3-[3-(2-{[3-(pyrrolidin-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2,6-difluoro-N-{3-[3-(2-{[3-(1H-imidazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[3-(1H-imidazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

N-{3-[3-(2-{[3-(1H-imidazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2,6-difluoro-N-{3-[3-(2-{[3-(1H-1,2,4-triazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

5-methyl-N-{3-[3-(2-{[3-(1H-1,2,4-triazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

2-phenyl-N-{3-[3-(2-{[3-(1H-1,2,4-triazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

2-thien-2-yl-N-{3-[3-(2-{[3-(1H-1,2,4-triazol-1-ylmethyl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}acetamide;

2,6-difluoro-N-[3-(3-{2-[(1-methyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

5-methyl-N-[3-(3-{2-[(1-methyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-[3-(3-{2-[(1-methyl-2,3-dihydro-1H-indol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({3-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[(3-hydroxypyrrolidin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl)phenyl}-2-thien-2-ylacetamide;

N-[3-(3-{2-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-3-ylacetamide;

2-chloro-N-[3-(3-{2-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-3-ylacetamide;

2-chloro-N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2,6-difluoro-N-{3-[3-(2-{[2-(methoxyacetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[2-(methoxyacetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[2-(methoxyacetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-phenylacetamide;

N-{3-[3-(2-{[2-(methoxyacetyl)-1,2,3,4-tetrahydroisoquinolin-6-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-phenylurea;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-(1,3-thiazol-5-yl)acetamide;

N-[3-(3-{2-[(3-{[4-(dimethylamino)piperidin-1-yl]methyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-phenylurea;

N-{3-[3-(2-{[4-(2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(7-acetyl-2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

tert-butyl 7-(4-{[4-(2-{3-[(2,6-difluorobenzoyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate;

tert-butyl 7-(4-{[4-(2-{3-[(thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-2,7-diazaspiro[4.4]nonane-2-carboxylate;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-5-methylthiophene-2-carboxamide;

N-(2,6-difluorophenyl)-N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-{3-[3-(2-{[4-(2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]-N-(2-fluorophenyl)benzamide;

3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]N-phenylbenzamide;

N-benzyl-3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino)}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide;

2,6-difluoro-N-{3-[3-(2-{[3-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2,6-difluoro-N-{3-[3-(2-{[3-(tetrahydrofuran-2-ylmethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-chloro-N-{3-[3-(2-{[3-(tetrahydrofuran-2-ylmethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[3-(tetrahydrofuran-2-ylmethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

N-{3-[3-(2-{[3-(tetrahydrofuran-2-ylmethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[3-(tetrahydrofuran-2-ylmethoxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-thien-2-ylurea;

2,6-difluoro-N-{3-[3-(2-{[3-(tetrahydrofuran-3-yloxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-chloro-N-{3-[3-(2-{[3-(tetrahydrofuran-3-yloxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[3-(tetrahydrofuran-3-yloxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydro isoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-thiazole-2-carboxamide;

N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-1,3-thiazole-5-carboxamide;

4-bromo-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

4-bromo-N-[3-(3-{2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-3-carboxamide;

N-{3-[3-(2-{[3-(tetrahydrofuran-3-yloxy)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-thien-2-ylurea;

N-(3-{3-[2-({3-[(dimethylamino)sulfonyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[(dimethylamino)sulfonyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

2-chloro-N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)thiophene-2-carboxamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-4-methylthiophene-2-carboxamide;

1-methyl-N-[3-(3-(2-[(2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)phenyl]-1H-pyrazole-3-carboxamide;

2-chloro-N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-3-fluorobenzamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-fluorobenzamide;

2-chloro-N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,3-difluorobenzamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,5-difluorobenzamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-3,5-difluorobenzamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-(3-{3-[2-({4-[1-(methoxyacetyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({4-[1-(methoxyacetyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({4-[1-(methoxyacetyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({3-[1-(methoxyacetyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2-chloro-N-{3-[3-(2-{[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-(3-{3-[2-({4-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({4-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-3-ylacetamide;

2,6-difluoro-N-(3-{3-[2-({4-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

2-chloro-N-(3-{3-[2-({4-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(N,N-dimethylglycyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

2-chloro-N-(3-{3-[2-({3-[(N,N-dimethylglycyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(N,N-dimethylglycyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)thiophene-2-carboxamide;

N 2 ,N 2 -dimethyl-N′-(3-{[4-(2-{3-[(thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)glycinamide;

2,6-difluoro-N-(3-{3-[2-({3-[(methoxyacetyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

2-chloro-N-(3-{3-[2-({3-[(methoxyacetyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[(2-methoxyacetyl)amino]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)thiophene-2-carboxamide;

2-methoxy-N-(3-{[4-(2-{3-[(thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)acetamide;

2-methoxy-N-[3-({4-[2-(3-{[(thien-2-ylamino)carbonyl]amino}phenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-yl}amino)phenyl]acetamide;

N-(3-{3-[2-({4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

2-chloro-N-(3-{3-[2-({4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)thiophene-2-carboxamide;

N-(3-{3-[2-({4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-thien-2-ylurea;

2,6-difluoro-N-(3-{3-[2-({3-[2-(methylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({3-[2-(methylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(methylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[2-(dimethylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)-2-oxoethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-4-methylthiophene-2-carboxamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-5-methylthiophene-2-carboxamide;

2-chloro-N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-5-fluorobenzamide;

2,6-difluoro-N-(3-{3-[2-({4-[2-(methylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

2-chloro-N-(3-{3-[2-({4-[2-(methylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)benzamide;

N-(3-{3-[2-({4-[2-(methylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({4-[2-(methylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({-4-[2-(methylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-methylbenzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-3-ylacetamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-[3-(3-{2-[(4-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-3-ylacetamide;

2-chloro-N-[3-(3-{2-[(4-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-3-ylacetamide;

N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2-chloro-N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

2-methyl-N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-piperidin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]indoline-1-carboxamide;

N-{3-[3-(2-{[4-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-(2-{[4-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-(2-{[4-(7-ethyl-2,7-diazaspiro[4.4]non-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-3-ylacetamide;

N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2-chloro-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2,3-difluoro-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2,5-difluoro-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-methyl-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2,6-dimethyl-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,3-difluorobenzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,5-difluorobenzamide;

2-chloro-N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-5-fluorobenzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)indoline-1-carboxamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,3-difluorobenzamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,5-difluorobenzamide;

2-chloro-N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-5-fluorobenzamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}indoline-1-carboxamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,3-difluorobenzamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[(dimethylamino)methyl]-4-methoxyphenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-thien-2-ylurea;

N-[3-(3-{2-[(3-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

2,6-difluoro-N-[3-(3-{2-[(3-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-chloro-N-[3-(3-{2-[(3-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-thien-2-ylurea;

N-[3-(3-{2-[(3-{2-[(3S)-3-fluoropyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-thien-3-ylurea;

N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]indoline-1-carboxamide;

N-ethyl-N-phenyl-N′-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]urea;

N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-1-benzothiophene-7-carboxamide;

N-(3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)-5-fluoropyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

2,6-difluoro-N-{3-[3-(2-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2-chloro-N-{3-[3-(2-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}thiophene-2-carboxamide;

N-{3-[3-(2-{[4-(4-hydroxypiperidin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-[3-(3-{2-[(4-{2-[(N,N-dimethylglycyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

2-chloro-N-[3-(3-{2-[(4-{2-[(N,N-dimethylglycyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4-{2-[(N,N-dimethylglycyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N 2 ,N 2 -dimethyl-N 1 -[2-(4-{[4-(2-{3-[(thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)ethyl]glycinamide;

N-[3-(3-{2-[(4-{2-[(N,N-dimethylglycyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,3-difluorobenzamide;

N-[3-(3-{2-[(4-{2-[(N,N-dimethylglycyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,5-difluorobenzamide;

N 2 ,N 2 -dimethyl-N 1 -[2-(4-{[4-(2-{3-[(phenylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)ethyl]glycinamide;

2,6-difluoro-N-[3-(3-{2-[(4-{2-[(methoxyacetyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-methoxy-N-[2-(4-{[4-(2-{3-[(thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)ethyl]acetamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)thiophene-2-carboxamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-chlorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-fluorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,3-difluorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,5-difluorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-chloro-5-fluorobenzamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)indoline-1-carboxamide;

N-(3-{3-[2-({4-[2-(4-aminopiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2-chloro-3-fluorobenzamide;

N-[2-(4-{[4-(2-{3-[(2-thien-2-ylacetyl)amino]phenyl}imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)ethyl]cyclopropanecarboxamide;

N-[3-(3-{2-[(4-{2-[(cyclopropylcarbonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

2-chloro-N-[3-(3-{2-[(4-{2-[(cyclopropylcarbonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4-{2-[(cyclopropylcarbonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

2,6-difluoro-N-[3-(3-{2-[(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-chloro-N-[3-(3-{2-[(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4{2-[(methylsulfonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-[3-(3-{2-[(4-{2-[(methylsulfonyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2-chloro-N-[3-(3-{2-[(4-{2-[(methoxyacetyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4-{2-[(2-methoxyacetyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-(2,6-difluorophenyl)-3-[3-(2-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]benzamide;

2,6-difluoro-N-[3-(3-{2-[(4-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

2-chloro-N-[3-(3-{2-[(4-{2-[(2-hydroxyethyl)(methyl)amino]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-phenylbenzamide;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-(2-fluorophenyl)benzamide;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-(3-fluorophenyl)benzamide;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-(4-fluorophenyl)benzamide;

N-cyclopentyl-3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}benzamide;

N-cyclohexyl-3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}benzamide;

N-{4-[2-(dimethylamino)ethyl]phenyl}-4-{2-[3-(piperidin-1-ylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-amine;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-(2-methylphenyl)benzamide;

N-(2-chlorophenyl)-3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}benzamide;

3-{3-[2-({4-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-(2-methoxyphenyl)benzamide;

N-{4-[2-(dimethylamino)ethyl]phenyl}-4-{2-[3-(morpholin-4-ylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-amine;

N-[3-(3-{2-[(3-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]indoline-1-carboxamide;

N-[3-(3-{2-[(3-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-3,4-dihydroquinoline-1(2H)-carboxamide;

N-[3-(3-{2-[(3-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-3,4-dihydroisoquinoline-2(1H)-carboxamide;

4-{2-[3-(2,3-dihydro-1H-indol-1-ylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl}-N-(4-[2-(dimethylamino)ethyl]phenyl}pyrimidin-2-amine;

4-{2-[3-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl}-N-{4-[2-(dimethylamino)ethyl]phenyl}pyrimidin-2-amine;

N-{4-[2-(dimethylamino)ethyl]phenyl}-4-{2-[3-(pyrrolidin-1-ylcarbonyl)phenyl]imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-amine;

N-{3-[3-(2-{[4-(1-acetylazetidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-chlorobenzamide;

N-{3-[3-(2-{[4-(1-acetylazetidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-3-ylacetamide;

N-cyclohexyl-N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-(sec-butyl)-N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-(tert-butyl)-N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-isopropylurea;

N-cyclopentyl-N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-[(1S)-1,2-dimethylpropyl]urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-[(1S)-1-phenylethyl]urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-(3,5-dimethylisoxazol-4-yl)urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-thien-2-ylurea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-(2-methyl-phenyl)urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)indoline-1-carboxamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)piperidine-1-carboxamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-thien-3-ylurea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)morpholine-4-carboxamide;

2,3-dimethyl-N-[3-(3-{2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(4-pyrrolidin-2-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2-chloro-N-[3-(3-{2-[(4-pyrrolidin-2-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,6-difluorobenzamide;

2-chloro-N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]thiophene-2-carboxamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,3-difluorobenzamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2,5-difluorobenzamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-phenylacetamide;

N-[3-(3-{2-[(3-{2-[3-(dimethylamino)pyrrolidin-1-yl]ethyl}phenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-N′-phenylurea;

N-{3-[3-(2-{[4-(1-acetylazetidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}indoline-1-carboxamide;

N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,3-dimethylbenzamide;

N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-2,3-dimethylbenzamide;

2-amino-N-[3-{3-(2-[(4-pyrrolidin-3-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]-2-thien-2-ylacetamide;

2-amino-N-{3-[3-(2-{[2-(dimethylamino)-2,3-dihydro-1H-inden-5-yl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2-amino-N-(3-{3-[2-({4-[4-(dimethylamino)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl)phenyl}-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-[(1R)-1-phenylethyl]urea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N′-(2-phenylcyclopropyl)urea;

N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N,N-dimethylurea;

N′-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)-N-methyl-N-phenylurea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}phenyl)pyrrolidine-1-carboxamide;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-phenylurea;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-[(1S)-1-phenylethyl]urea;

N-{3-[3-(2-{[4-(1-ethylpyrrolidin-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2-chloro-N-{3-[3-(2-{[4-(1-ethylpyrrolidin-2-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-3-ylacetamide;

N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide;

2-chloro-N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

2,3-difluoro-N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}benzamide;

N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-[(1S)-1-phenylethyl]urea;

N-(2-fluorophenyl)-3-{3-[2-({3-[2-(4-hydroxypiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}benzamide;

3-{3-[2-({3-[2-(4-hydroxypiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-phenylbenzamide;

N′-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N,N-dimethylurea;

N′-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N-methyl-N-phenylurea;

3-{3-[2-({3-[2-(4-hydroxypiperidin-1-yl)ethyl]phenyl}amino)pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl}-N-thien-2-ylbenzamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-8-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-8-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-2-phenylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-8-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-8-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-3,4-dihydroquinoline-1(2H)-carboxamide;

N-benzyl-N′-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N-methylurea;

N-benzyl-N-(2-cyanoethyl)-N′-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}urea;

N′-{3-[3-(2-{[4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N-methyl-N-[(1S)-1-phenylethyl]urea;

N-{3-[3-(2-{([4-(1-isopropylpyrrolidin-3-yl)phenyl]amino}pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl}-5-methylindoline-1-carboxamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-N′-phenylurea;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-2-thien-2-ylacetamide;

N-(3-{3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-fluoroimidazo[1,2-a]pyridin-2-yl}phenyl)-2,6-difluorobenzamide;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-N′-phenylurea;

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2-thien-2-ylacetamide; and

N-{3-[3-[2-({3-[2-(dimethylamino)ethyl]phenyl}amino)pyrimidin-4-yl]-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl]phenyl}-2,6-difluorobenzamide; and salts, esters, amides, prodrugs and salts of esters, amides and prodrugs thereof.

4. A composition comprising an excipient and a therapeutically effective amount of a compound of claim 1 .