Transdermal pharmaceutical compositions comprising active agents
The present invention provides compositions and methods for providing sustained release of an active agent through the skin of a subject, wherein a pharmaceutical percutaneous composition comprises at least one fatty acid ester and a therapeutically effective amount of active agent.
1. A sustained release pharmaceutical composition for topical administration to a skin surface comprising:
a pharmaceutically active agent comprising one or more steroids;
0.01% to 5% by weight of the total weight of the pharmaceutical composition of a fatty acid ester;
water;
a C2-C6 monoalcohol;
a fatty acid; and
0.05% to 5% by weight of a gelling agent,
wherein the weight:weight ratio of the fatty acid ester in the composition to the total active agent in the composition is at least 4:1 fatty acid ester:active agent, and
wherein the pharmaceutically active agent is selected from one or more of estradiol and progesterone, and the fatty acid ester is ethyl oleate.
2. The composition of claim 1 , further comprising a co-solvent.
3. The composition according to claim 2 , wherein the co-solvent is present in an amount ranging from 0.01% to 7% by weight of the total weight of the pharmaceutical composition.
4. The composition according to claim 1 , wherein the fatty acid is oleic acid.
5. The composition according to claim 1 , wherein the fatty acid ester is present in an amount ranging from 0.05% to 2.4% by weight of the total weight of the pharmaceutical composition.
6. The composition according to claim 1 , wherein the fatty acid is a C8-C22 fatty acid selected from the group consisting of capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, palrnitoleic acid, linoleic acid and linolenic acid.
7. The composition according to claim 1 , wherein the fatty acid is present in an amount ranging from 0.01% to 5% by weight of the total weight of the pharmaceutical composition.
8. The composition according to claim 1 , comprising 2% ethyl oleate as the fatty acid ester, 2% oleic acid as the fatty acid, and 5% propylene glycol as the co-solvent, all by weight of the total weight of the pharmaceutical composition.
9. The composition according to claim 1 , comprising 0.3% ethyl oleate as the fatty acid ester, 0.3% oleic acid as the fatty acid, and 0.75% propylene glycol as the co-solvent, all by weight of the total weight of the pharmaceutical composition.
10. The composition according to claim 1 , wherein the pharmaceutically active agent is estradiol.
11. The composition according to claim 1 , wherein the active agent is present in an amount ranging from 0.01% to 5% by weight of the total weight of the pharmaceutical composition.
12. The composition according to claim 1 , wherein the C2-C6 monoalcohol is selected from the group consisting of ethanol, n-propanol, isopropanol, n-butanol, isobutanol, tert-butanol, and mixtures thereof.
13. The composition according to claim 1 , wherein the C2-C6 monoalcohol is present in an amount ranging from 10% to 90% by weight of the total weight of the pharmaceutical composition.