Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same

1. A method for preparing a crystalline S-omeprazole strontium tetrahydrate of formula (I), which comprises the step of adding strontium hydroxide to a neutral solution containing S-omeprazole of formula (III) and stirring the resulting mixture:

2. The method of claim 1 , wherein the strontium hydroxide is used in an amount ranging 0.5 to 0.75 molar equivalents based on 1 molar equivalent of S-omeprazole.

3. The method of claim 1 , wherein the neutral solution containing S-omeprazole of formula (III) is prepared by dissolving or suspending S-omeprazole in an organic solvent selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, acetonitrile, tetrahydrofuran, acetone and a mixture thereof, or in a mixture of one of the above-mentioned organic solvents and water.

4. The method of claim 3 , wherein the organic solvent is selected from methanol, acetone and a mixture thereof.

5. The method of claim 1 , wherein said S-omeprazole strontium tetrahydrate has X-ray powder diffraction spectrum showing major peaks having I/I o values of at least 3% at 2θ±0.2 of 5.6, 11.1, 13.5, 14.8, 16.2, 17.5, 18.0, 20.1, 20.4, 21.2, 22.2, 24.5, 25.2, 26.3, 27.5, 29.8, 31.1, 32.8 and 36.5.