Treatment of pain with topical diclofenac
View Patent ↗The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.
1. A method for applying topical agents to a knee of a patient with pain, said method comprising:
applying a first medication consisting of a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation comprises a therapeutically effective amount of diclofenac and 40-50% w/w dimethyl sulfoxide;
waiting for the treated area to dry; and
subsequently applying a second medication consisting of a topical medication, which is other than said first medication and is selected from the group consisting of an NSAID, tretinoin, minoxidil, a corticosteroid, to said treated area after said treated area is dry, wherein said subsequent application occurs during a course of treatment of said patient with said topical diclofenac preparation.
2. The method according to claim 1 , wherein said diclofenac preparation comprises about 45.5% w/w dimethyl sulfoxide.
3. The method according to claim 1 , wherein said therapeutically effective amount of diclofenac is 1.5% w/w diclofenac sodium.
4. The method according to claim 1 , wherein said diclofenac preparation further comprises ethanol, propylene glycol, glycerine, and water.
5. The method according to claim 1 , wherein said therapeutically effective amount of diclofenac comprises a pharmaceutically acceptable salt of diclofenac selected from a sodium salt, a potassium salt, a diethylamine salt, or an epolamine salt.
6. The method according to claim 1 , wherein said step of subsequently applying comprises subsequently applying said second medication, which is an NSAID.
7. The method according to claim 6 , wherein said topical medication other than said first medication comprises a medical compound or composition in an amount sufficient to induce a desired biological, pharmaceutical, or therapeutic result, wherein the result relates to alleviation of a sign, a symptom, or a cause of a disease or disorder or condition, or any other desired alteration of a biological system.
8. The method according to claim 1 , wherein the topical medication other than said first medication is tretinoin.
9. The method according to claim 5 , wherein said therapeutically effective amount of diclofenac comprises diclofenac sodium.
10. The method according to claim 1 , wherein the topical medication other than said first medication is minoxidil.
11. The method according to claim 1 , wherein the topical medication other than said first medication is a corticosteroid.
12. A method for applying topical agents to a knee of a patient with pain, said method comprising:
applying a first medication consisting of a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation comprises a therapeutically effective amount of diclofenac and 40-50% w/w dimethyl sulfoxide;
waiting for the treated area to dry; and
subsequently applying a second medication consisting of a topical medication, which is other than said first medication and comprises an NSAID, to said treated area after said treated area is dry, wherein said subsequent application occurs during a course of treatment of said patient with said topical diclofenac preparation.
13. The method according to claim 12 , wherein said therapeutically effective amount of diclofenac is 1.5% w/w diclofenac sodium.
14. A method for applying topical agents to a knee of a patient with pain, said method comprising:
applying a first medication consisting of a topical diclofenac preparation to an area of the knee of said patient to treat osteoarthritis of the knee of said patient, wherein the topical diclofenac preparation comprises a therapeutically effective amount of diclofenac and 40-50% w/w dimethyl sulfoxide;
waiting for the treated area to dry; and
subsequently applying a second medication consisting of a topical medication, which is other than said first medication and comprises a corticosteroid, to said treated area after said treated area is dry, wherein said subsequent application occurs during a course of treatment of said patient with said topical diclofenac preparation.
15. The method according to claim 14 , wherein said therapeutically effective amount of diclofenac is 1.5% w/w diclofenac sodium.