IP Library › Granted Patent US 8,543,354
Granted Patent B2
US 8,543,354 · App. 12/914,969 · Granted Sep 24, 2013

Glucose sensor signal stability analysis

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Quick Facts
Patent No.
US 8,543,354
App. No.
12/914,969
Granted
Sep 24, 2013
Kind
B2
Abstract

Disclosed are methods, apparatuses, etc. for glucose sensor signal stability analysis. In certain example embodiments, a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient may be obtained. Based at least partly on the series of samples, at least one metric may be determined to assess an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time. A reliability of the at least one sensor signal to respond to the blood glucose level of the patient may be assessed based at least partly on the at least one metric assessing an underlying trend. Other example embodiments are disclosed herein.

Claims (71)

1. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend,

wherein said assessing further comprises:

assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold;

assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and

assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.

2. The method of claim 1 , further comprising: generating an alert signal responsive to a comparison of the at least one metric assessing the underlying trend with at least one alert threshold.

3. The method of claim 1 , and further comprising: acquiring the at least one sensor signal from one or more subcutaneous glucose sensors, wherein the at least one metric assessing the underlying trend reflects an apparent reliability of the at least one sensor signal that is acquired from the one or more subcutaneous glucose sensors.

4. The method of claim 1 , and further comprising: altering an insulin infusion treatment for the patient responsive at least partly to the assessed reliability of the at least one sensor signal.

5. The method of claim 1 , wherein said determining further comprises:

producing the at least one metric assessing the underlying trend using a slope of a linear regression that is derived at least partly from the series of samples of the at least one sensor signal.

6. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said assessing further comprises:

comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold; and

ascertaining at least one value indicating a severity of divergence by the at least one sensor signal from the blood glucose level of the patient over time based at least partly on the at least one metric assessing the underlying trend, the first predetermined threshold, and the second predetermined threshold.

7. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

transforming the series of samples of the at least one sensor signal to derive a monotonic curve;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time, the at least one metric assessing the underlying trend being produced using a slope of a linear regression that is derived at least partly from the series of samples of the at least one sensor signal, the linear regression being derived at least partly from the monotonic curve; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend.

8. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time by decomposing the at least one sensor signal as represented by the series of samples using at least one empirical mode decomposition and one or more spline functions to remove relatively higher frequency components from the at least one sensor signal; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend.

9. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said determining comprises:

decomposing the at least one sensor signal as represented by the series of samples using at least one discrete wavelet transform; and reconstructing a smoothed signal from one or more approximation coefficients resulting from the at least one discrete wavelet transform.

10. A method comprising:

obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing the underlying trend, wherein said determining comprises: iteratively updating a trend estimation at multiple samples of the series of samples of the at least one sensor signal based at least partly on a trend estimation at a previous sample and a growth term.

11. An apparatus comprising:

a controller to obtain a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient, said controller comprising one or more processors to:

determine, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assess a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend by:

comparing the at least one metric assessing the underlying trend with at least a first predetermined threshold and a second predetermined threshold;

assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold;

assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and the second predetermined threshold; and

assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.

12. The apparatus of claim 11 , wherein said one or more processors of said controller are further to: generate an alert signal responsive to a comparison of the at least one metric assessing the underlying trend with at least one alert threshold.

13. The apparatus of claim 11 , wherein said controller is further capable of assessing the reliability of the at least one sensor signal to respond to the blood glucose level of the patient by: ascertaining at least one value indicating a severity of divergence by the at least one sensor signal from the blood glucose level of the patient over time based at least partly on the at least one metric assessing the underlying trend, the first predetermined threshold, and the second predetermined threshold.

14. The apparatus of claim 11 , wherein said one or more processors of said controller are further to: acquire the at least one sensor signal from one or more subcutaneous glucose sensors, wherein the at least one metric assessing the underlying trend reflects an apparent reliability of the at least one sensor signal that is acquired from the one or more subcutaneous glucose sensors.

15. The apparatus of claim 11 , wherein said one or more processors of said controller are further to: alter an insulin infusion treatment for the patient responsive at least partly to the assessed reliability of the at least one sensor signal.

16. The apparatus of claim 11 , wherein said controller is capable of determining said at least one metric assessing the underlying trend by: producing the at least one metric assessing the underlying trend using a slope of a linear regression that is derived at least partly from the series of samples of the at least one sensor signal.

17. The apparatus of claim 16 , wherein said one or more processors of said controller are further to: transform the series of samples of the at least one sensor signal to derive a monotonic curve, wherein said controller is capable of producing the at least one metric assessing the underlying trend by calculating the slope of the linear regression, the linear regression being derived at least partly from the monotonic curve.

18. The apparatus of claim 11 , wherein said controller is capable of determining said at least one metric assessing the underlying trend by: decomposing the at least one sensor signal as represented by the series of samples using at least one empirical mode decomposition and one or more spline functions to remove relatively higher frequency components from the at least one sensor signal.

19. The apparatus of claim 11 , wherein said controller is capable of determining said at least one metric assessing the underlying trend by:

decomposing the at least one sensor signal as represented by the series of samples using at least one discrete wavelet transform; and

reconstructing a smoothed signal from one or more approximation coefficients resulting from the at least one discrete wavelet transform.

20. The apparatus of claim 11 , wherein said controller is capable of determining said at least one metric assessing the underlying trend by: iteratively updating a trend estimation at multiple samples of the series of samples of the at least one sensor signal based at least partly on a trend estimation at a previous sample and a growth term.

21. A system comprising:

means for obtaining a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

means for determining, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

means for assessing a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend, wherein said means for assessing said reliability of the at least one sensor signal to respond to the blood glucose level further comprises:

means for assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold;

means for assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and

means for assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.

22. An article comprising:

at least one storage medium having stored thereon instructions executable by one or more processors to:

obtain a series of samples of at least one sensor signal that is responsive to a blood glucose level of a patient;

determine, based at least partly on the series of samples, at least one metric assessing an underlying trend of a change in responsiveness of the at least one sensor signal to the blood glucose level of the patient over time; and

assess a reliability of the at least one sensor signal to respond to the blood glucose level of the patient based at least partly on the at least one metric assessing an underlying trend by:

assessing that the reliability of the at least one sensor signal is in a first state responsive to a comparison of the at least one metric assessing the underlying trend with the a predetermined threshold;

assessing that the reliability of the at least one sensor signal is in a second state responsive to a comparison of the at least one metric assessing the underlying trend with the first predetermined threshold and a second predetermined threshold; and

assessing that the reliability of the at least one sensor signal is in a third state responsive to a comparison of the at least one metric assessing the underlying trend with the second predetermined threshold.

Assignments (1)
SECURITY INTEREST Recorded Jan 16, 2026
From: MEDTRONIC MINIMED, INC.; COMPANION MEDICAL, INC.
To: CITIBANK, N.A.
Reel/Frame 074394/0237 →