IP Library › Granted Patent US 8,338,392
Granted Patent B2
US 8,338,392 · App. 12/918,183 · Granted Dec 25, 2012

MicroRNA modulators and method for identifying and using the same

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Quick Facts
Patent No.
US 8,338,392
App. No.
12/918,183
Granted
Dec 25, 2012
Kind
B2
Abstract

The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.

Claims (3)

1. An miR-21 antagonist having the structure of compound 2:

2. A pharmaceutical composition comprising the miR-21 antagonist having the structure of compound 2:

in admixture with a pharmaceutically acceptable carrier.