Oligomer-foscarnet conjugates
View Patent ↗The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
1. A pharmaceutical composition comprising a compound and a pharmaceutically acceptable excipient, wherein the compound has the following structure:
wherein:
X is a spacer moiety of less than about five atoms;
and POLY is a water-soluble, non-peptidic oligomer, wherein the water-soluble, non-peptidic oligomer comprises 3 to 30 monomers of an alkylene oxide.
2. The pharmaceutical composition of claim 1 , wherein the alkylene oxide is an ethylene oxide.
3. The pharmaceutical composition of claim 1 , wherein the alkylene oxide includes an alkoxy or hydroxy end-capping moiety.
4. The pharmaceutical composition of claim 1 , wherein the spacer moiety is a stable linkage.
5. The pharmaceutical composition of claim 1 , wherein the spacer moiety is a degradable linkage.
6. The compound of claim 1 , wherein the spacer moiety is an ester linkage.