Partial peptide of lacritin
The invention provides a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, which is a particular partial sequence of lacritin, and having an amino acid length of not more than 70 residues. The polypeptide of the invention can promote adhesion between a cell and an extracellular matrix, and can promote tear fluid secretion from lacrimal gland acinar cells.
1. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO: 1 and having an amino acid length of not more than 70 residues.
2. A pharmaceutical product comprising the polypeptide of claim 1 .
3. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 1 , thereby promoting adhesion of the corneal epithelial cell.
4. The polypeptide according to claim 1 , wherein the polypeptide comprises a partial sequence of the amino acid sequence of SEQ ID NO: 2.
5. A pharmaceutical product comprising the polypeptide of claim 4 .
6. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 4 , thereby promoting adhesion of the corneal epithelial cell.
7. The polypeptide according to claim 1 , wherein the polypeptide consists of a partial sequence of the amino acid sequence of SEQ ID NO: 2.
8. A pharmaceutical product comprising the polypeptide of claim 7 .
9. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 7 , thereby promoting adhesion of the corneal epithelial cell.
10. An isolated polypeptide consisting of the amino acid sequence of any of SEQ ID NOs: 3-5.
11. A pharmaceutical product comprising the polypeptide of claim 10 .
12. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 10 , thereby promoting adhesion of the corneal epithelial cell.
13. The polypeptide of claim 10 consisting of the amino acid sequence of SEQ ID NO: 3.
14. A pharmaceutical product comprising the polypeptide of claim 13 .
15. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 13 , thereby promoting adhesion of the corneal epithelial cell.
16. The polypeptide of claim 10 consisting of the amino acid sequence of SEQ ID NO: 4.
17. A pharmaceutical product comprising the polypeptide of claim 16 .
18. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 16 , thereby promoting adhesion of the corneal epithelial cell.
19. The polypeptide of claim 10 consisting of the amino acid sequence of SEQ ID NO: 5.
20. A pharmaceutical product comprising the polypeptide of claim 19 .
21. A method of promoting corneal epithelial cell adhesion, which method comprises contacting a corneal epithelial cell with an effective concentration of the polypeptide of claim 19 , thereby promoting adhesion of the corneal epithelial cell.