IP Library › Patent Application 12925297

Patent Application

App. No. 12/925,297

Bicycloheteroaryl compounds as P2X7 modulators and uses thereof

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Patent No.: US None
App. No.: 12/925,297

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Abstract

Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Claims (576)

1 . A bicycloheteroaryl compound having a formula:

wherein

B and Y are independently selected from CR 2a and CR 2a R 2b ;

W, W′ and Z are independently selected from CR 4 and N, provided that all three of

W, W′ and Z are not N at the same time;

L 1 is substituted or unsubstituted C 1 -C 5 alkylene;

n is 0, 1, 2, 3 or 4;

R 1 is selected from substituted or unsubstituted 5-13 membered aryl and heteroaryl;

each R 2a , R 2b , R 2′ and R 2″ is independently selected from hydrogen, halo, substituted or unsubstituted C 1 -C 6 alkyl; or any of R 2′ and R 2″ join together to form a cycloalkyl or cycloheteroalkyl ring of 3-7 atoms;

R 3 is a hydrogen bond donor group;

each R 4 is independently selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;

and the dotted bond is a single or a double bond;

or a pharmaceutically acceptable salt thereof;

and stereoisomers, isotopic variants and tautomers thereof.

2 . (canceled)

3 . A compound according to claim 1 wherein each of B and Y is CH 2 ; and the dotted bond is a single bond.

4 . (canceled)

5 . A compound according to claim 1 wherein each of B and Y is CH; and the dotted bond is a double bond.

6 . A compound according to claim 1 wherein each of R 2′ and R 2″ is H.

7 . A compound according to claim 1 wherein one of R 2′ and R 2″ is independently Me and the other is H.

8 . A compound according to claim 1 wherein each of R 2′ and R 2″ is Me.

9 . A compound according to claim 1 wherein n is 0, 1, or 2.

10 . (canceled)

11 . A compound according to claim 1 wherein R 1 is selected from a 5-13 membered aryl and heteroaryl, unsubstituted or substituted with one or more substituents independently selected from halo, hydroxyl, amino, cyano, sulfo, sulfanyl, sulfinyl, amido, carboxy, carbalkoxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, and sulfonamide.

12 . A compound according to claim 1 wherein R 1 is substituted or unsubstituted aryl.

13 . A compound according to claim 1 wherein R 1 is substituted or unsubstituted phenyl.

14 . (canceled)

15 . (canceled)

16 . A compound according to claim 1 wherein R 1 is substituted or unsubstituted pyridyl, substituted or unsubstituted quinoline, substituted or unsubstituted benzodioxole, substituted or unsubstituted benzodioxane, substituted or unsubstituted benzofuran, substituted or unsubstituted benzothiophene, and substituted or unsubstituted benzodioxepine.

17 . A compound according to claim 1 wherein the compound is according to formula I, II, III or IV:

wherein

W is CR 4 ; Z is CR 4 ;

L 1 , R 1 , R 2′ , R 2″ , R 3 and R 4 are as in claim 1 ;

and R 5 is selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;

or a pharmaceutically acceptable salt, solvate or prodrug thereof;

and stereoisomers, isotopic variants and tautomers thereof.

18 . (canceled)

19 . (canceled)

20 . (canceled)

21 . (canceled)

22 . (canceled)

23 . A compound according to claim 1 wherein the compound is according to formula V, VI or VII:

wherein

W is CR 4 ; Z is CR 4 ;

L 1 , R 1 R 2′ , R 2″ , R 3 and R 4 are as in claim 1 ;

R 5 is selected from H, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio;

R 4a is selected from hydrogen, alkyl, substituted alkyl, acyl, substituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, aryloxy, alkoxycarbonyl, substituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, arylalkyloxy, substituted arylalkyloxy, amino, aryl, substituted aryl, arylalkyl, substituted or unsubstituted sulfoxide, substituted or unsubstituted sulfone, substituted or unsubstituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted arylsulfonyl, sulfuric acid, sulfuric acid ester, substituted or unsubstituted dihydroxyphosphoryl, substituted or unsubstituted aminodihydroxyphosphoryl, azido, carboxy, substituted or unsubstituted carbamoyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thio; and m is selected from 0-5;

or a pharmaceutically acceptable salt, solvate or prodrug thereof;

and stereoisomers, isotopic variants and tautomers thereof.

24 . (canceled)

25 . (canceled)

26 . (canceled)

27 . (canceled)

28 . (canceled)

29 . A compound according to claim 1 wherein the compound is according to formula VIII, IX or X

wherein

W is CR 4 ; Z is CR 4 ;

L 1 , R 3 and R 4 are as described in claim 1 ; R 2′ is H or Me;

or a pharmaceutically acceptable salt, solvate or prodrug thereof;

and stereoisomers, isotopic variants and tautomers thereof.

30 . (canceled)

31 . (canceled)

32 . (canceled)

33 . (canceled)

34 . (canceled)

35 . (canceled)

36 . (canceled)

37 . (canceled)

38 . (canceled)

39 . (canceled)

40 . (canceled)

41 . (canceled)

42 . (canceled)

43 . (canceled)

44 . (canceled)

45 . (canceled)

46 . (canceled)

47 . (canceled)

48 . (canceled)

49 . (canceled)

50 . (canceled)

51 . (canceled)

52 . (canceled)

53 . (canceled)

54 . (canceled)

55 . (canceled)

56 . (canceled)

57 . (canceled)

58 . (canceled)

59 . (canceled)

60 . (canceled)

61 . A compound according to claim 1 wherein the compound is selected from

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-phenyl)-acetamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-phenyl-propionamide;

2-(4-Chloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-dimethoxy-benzamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-bis-trifluoromethyl-benzamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

2-(3,4-Dichloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

5-Phenyl-furan-2-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(3-methoxy-phenyl)-propionamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2,4,6-trimethyl-phenyl)-acetamide;

2-(2,5-Dimethyl-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-benzamide;

3-Ethoxy-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

3-(2-Chloro-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

3-Benzo[1,3]dioxol-5-yl-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

4-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,5-dimethyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3,5-dimethoxy-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

4-Ethoxy-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

Biphenyl-4-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

4-tert-Butyl-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-phenyl-propionamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(4-methoxy-phenyl)-propionamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-naphthalen-1-yl-acetamide;

Naphthalene-2-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-(2-Fluoro-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-methoxy-phenyl)-acetamide;

2-(2,5-Dimethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dimethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-m-tolyl-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-phenyl)-acetamide;

2-(4-Ethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-p-tolyl-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-phenyl-butyramide;

Benzofuran-2-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[1,3]dioxol-5-yl-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Dimethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3,5-dimethyl-benzamide;

3-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methyl-benzamide;

4-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3,4-Dihydro-2H-benzo[b][1,4]dioxepine-7-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[b]thiophen-3-yl-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Dimethyl-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Dimethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

4-Fluoro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

3-(4-Chloro-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(2-Ethoxy-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-5-methyl-benzamide;

5-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-m-tolyl-propionamide;

5-Chloro-benzofuran-2-carboxylic acid [2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Chloro-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3-methyl-benzamide;

3-(2,4-Dimethyl-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

3-(3-Chloro-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-isobutyl-benzamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

3-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

3-(2,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Bromo-4-methoxy-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Chloro-5-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]acetamide;

2-(5-Chloro-2-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Dichloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,5-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(4-methanesulfonyl-phenyl)-propionamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methanesulfonyl-phenyl)-acetamide;

2-(4-Fluoro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-phenyl-butyramide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-methoxy-phenyl)-acetamide;

N-[2-(2-Hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-phenylacetamide;

2-(2,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-butyramide;

1-(4-Chloro-phenyl)-cyclopentanecarboxylic acid [2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-(3,4-Dichloro-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Dichloro-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-2-methyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-o-tolyl-propionamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,3-dimethyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-dimethyl-benzamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(2-methoxy-phenyl)-propionamide;

2-(2-Chloro-phenyl)-N-[2-(1-hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(1-Hydroxy-cyclohexylmethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-o-tolyl-acetamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-o-tolyl-propionamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(3-methoxy-phenyl)-propionamide;

3-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-benzamide;

3-Ethoxy-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

3-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

2,4-Dichloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

2,5-Dichloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,3-dimethyl-benzamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-dimethyl-benzamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,5-dimethyl-benzamide;

4-Ethoxy-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

Biphenyl-4-carboxylic acid [2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-phenyl-propionamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(2-methoxy-phenyl)-propionamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(4-methoxy-phenyl)-propionamide;

Naphthalene-1-carboxylic acid [2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-methoxy-phenyl)-acetamide;

2-(2,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dimethoxy-phenyl)-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-phenyl)-acetamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-phenyl-butyramide;

Benzofuran-2-carboxylic acid [2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Dim ethoxy-phenyl)-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methyl-benzamide;

2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid [2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3,4-Dihydro-2H-benzo[b][1,4]dioxepine-7-carboxylic acid [2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2-(3,5-Dimethyl-phenyl)-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Dimethoxy-phenyl)-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-5-methyl-benzamide;

5-Chloro-N-[2-(2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

N-[2-(2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3-methyl-benzamide;

4-Ethoxy-2-hydroxy-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-2-methyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-o-tolyl-propionamide;

5-Phenyl-furan-2-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(3-methoxy-phenyl)-propionamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2,4,6-trimethyl-phenyl)-acetamide;

2-(2,5-Dimethyl-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-benzamide;

3-Ethoxy-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

3-(2-Chloro-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

3-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

4-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

2-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

2,4-Dichloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide,

2,5-Dichloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,3-dimethyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-dimethyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,5-dimethyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3,5-dimethoxy-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

4-Ethoxy-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

Biphenyl-4-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

4-tert-Butyl-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-phenyl-propionamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(2-methoxy-phenyl)-propionamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(4-methoxy-phenyl)-propionamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-naphthalen-1-yl-acetamide;

Naphthalene-2-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-(2-Fluoro-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Chloro-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-methoxy-phenyl)-acetamide;

2-(2,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-o-tolyl-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-methoxy-phenyl)-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-m-tolyl-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-phenyl)-acetamide;

2-(4-Ethoxy-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-p-tolyl-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-phenyl-butyramide;

Benzofuran-2-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3,5-dimethyl-benzamide;

3-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methyl-benzamide;

4-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3,4-Dihydro-2H-benzo[b][1,4]dioxepine-7-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2-(3,5-Dimethyl-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Dimethoxy-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

4-Fluoro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

2-(2-Ethoxy-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-3-methyl-phenyl)-acetamide;

2-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-5-methyl-benzamide;

5-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-m-tolyl-propionamide;

5-Chloro-benzofuran-2-carboxylic acid [2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Chloro-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

N-[2-(2-Hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3-methyl-benzamide;

3-(2,4-Dimethyl-phenyl)-N-[2-(2-hydroxy-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

4-Ethoxy-2-hydroxy-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-2-methyl-benzamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-o-tolyl-propionamide;

5-Phenyl-furan-2-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-(3-methoxy-phenyl)-propionamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2,4,6-trimethyl-phenyl)-acetamide;

2-(2,5-Dimethyl-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-benzamide;

3-Ethoxy-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

3-(2-Chloro-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

3-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

4-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-3-methyl-benzamide;

2-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

2,4-Dichloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

2,5-Dichloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,4-dimethyl-benzamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2,5-dimethyl-benzamide;

3,5-Dichloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-benzamide;

Naphthalene-1-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-naphthalen-1-yl-acetamide;

Naphthalene-2-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-(2-Fluoro-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Chloro-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-methoxy-phenyl)-acetamide;

2-(2,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-o-tolyl-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-methoxy-phenyl)-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-m-tolyl-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-methoxy-phenyl)-acetamide;

2-(4-Ethoxy-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-p-tolyl-acetamide;

Benzofuran-2-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[1,3]dioxol-5-yl-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,5-Dimethoxy-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methyl-benzamide;

4-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2,3-Dihydro-benzo[1,4]dioxine-5-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

3,4-Dihydro-2H-benzo[b][1,4]dioxepine-7-carboxylic acid [2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

2-Benzo[b]thiophen-3-yl-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

3-Chloro-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-methyl-benzamide;

2-(3,5-Dimethyl-phenyl)-N-[2-(2-hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-4-methoxy-3-methyl-benzamide;

2-(4-Chloro-2-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-2-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-(1-oxo-2-(S)-1-pyrrolidin-2-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-acetamide;

2-(2,4-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1-hydroxymethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dichloro-phenyl)-N-[2-(2-methylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-(2-methylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(S)-2-{5-[2-(3,4-Dichloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-2-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3,4-Dichloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-2-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(4-Chloro-phenyl)-N-(1-oxo-2-(R)-1-pyrrolidin-2-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-propionamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-(1-oxo-2-(R)-1-pyrrolidin-2-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-acetamide;

2-(4-Chloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(3,4-Dichloro-phenyl)-N-(1-oxo-2-(R)-1-pyrrolidin-2-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-acetamide;

2-(4-Chloro-phenyl)-N-(1-oxo-2-(S)-1-pyrrolidin-2-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-propionamide;

(R)-2-{5-[2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

N-[6-Chloro-2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3,4-dichloro-phenyl)-acetamide;

2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-acetamide;

(S)-2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-3-hydroxy-propionamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

(R)-2-{5-[2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-hydroxy-propionamide;

(S)-2-{5-[2-(3,4-Dichloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-3-hydroxy-propionamide;

(R)-2-{5-[2-(3,4-Dichloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Chloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-(1-oxo-2-piperidin-4-ylmethyl-1,2-dihydro-isoquinolin-5-yl)-acetamide;

N-[2-(3-Amino-2-chloromethyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-chloro-3-trifluoromethyl-phenyl)-acetamide;

N-[2-(3-Amino-2-chloromethyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3,4-dichloro-phenyl)-acetamide;

(R)-2-{5-[2-(2-Chloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-hydroxy-N-methyl-propionamide;

(R)-2-{5-[(R)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

N-[2-((R)-1-Carbamoyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-chloro-phenyl)-isobutyramide;

(S)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[(R)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[(S)-2-(3,4-Dichloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[(R)-2-(3,4-Dichloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3,4-Dichloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-hydroxy-N-methyl-propionamide;

(S)-2-(4-Chloro-phenyl)-N-[2-((R)-1-hydroxymethyl-3-methyl-butyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

Quinoline-5-carboxylic acid [2-((R)-1-carbamoyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-amide;

(R)-2-(4-Chloro-phenyl)-N—[(R)-2-(1-hydroxymethyl-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

(S)-2-(4-Chloro-phenyl)-N-[2-((R)-1-hydroxymethyl-2-methyl-propyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(3,4-Dichloro-phenyl)-N-[2-((R)-1-hydroxymethyl-3-methyl-butyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3,N-dimethyl-butyramide;

(R)-2-{5-[(R)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3,N-dimethyl-butyramide;

(S)—N-[2-((R)-Carbamoyl-phenyl-methyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3,4-dichloro-phenyl)-propionamide;

(S)—N-[2-((R)-Carbamoyl-phenyl-methyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-chloro-phenyl)-propionamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-((R)-1-hydroxymethyl-3-methyl-butyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-N-cyclopropyl-3-methyl-butyramide;

(R)-2-{5-[(R)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-N-cyclopropyl-3-methyl-butyramide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-methyl-butyramide;

(R)-2-{5-[(R)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-methyl-butyramide;

(R)-2-{5-[2-(2-Fluoro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2-Fluoro-6-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Cyano-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Cyano-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-(2-Biphenyl-4-yl-acetylamino)-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-2-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2-Chloro-4-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2,6-Difluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2,4-Difluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2-Fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Fluoro-2-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2-Fluoro-4-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(3-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(4-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Fluoro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Chloro-3-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Chloro-4-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Fluoro-4-methyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3,4-Difluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(4-Fluoro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(2,4,5-trifluoro-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(3-Bromo-4-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-N-cyclopropyl-propionamide;

(R)-2-[1-Oxo-5-(2-pyridin-2-yl-acetylamino)-1H-isoquinolin-2-yl]-propionamide;

(S)-2-{5-[2-(6-Chloro-pyridin-3-yl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(4-trifluoromethoxy-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(6-Chloro-pyridin-3-yl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(3-trifluoromethoxy-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{5-[2-(2,4-Dichloro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)—N-{2-[Carbamoyl-(4-chloro-phenyl)-methyl]-1-oxo-1,2-dihydro-isoquinolin-5-yl}-2-(4-chloro-phenyl)-propionamide;

(R)-2-{6-Chloro-1-oxo-5-[2-(4-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-(3,4-Dichloro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

N-[2-((S)-2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

N-[2-((R)-2-Hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

(R)-2-(3,4-Dichloro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

(S)-2-(3,4-Dichloro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionic acid;

(R)-2-{5-[(S)-2-(4-Chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-3-methyl-butyric acid;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(S)-2-(3,4-Dichloro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-propionamide;

2-(4-Chloro-2-fluoro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-2-fluoro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Chloro-4-fluoro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Chloro-4-fluoro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dichloro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dichloro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(R)-2-{5-[2-(2-Fluoro-3-trifluoromethyl-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(4-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((S)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(R)-2-{6-Chloro-5-[(S)-2-(4-chloro-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(3-Chloro-4-fluoro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]acetamide;

(R)-2-{6-Chloro-5-[2-(2-fluoro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{6-Chloro-5-[2-(4-chloro-2-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{6-Methoxy-1-oxo-5-[2-(4-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{6-Chloro-1-oxo-5-[2-(4-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(3-Chloro-4-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Fluoro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(2-Fluoro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-2-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{1-Oxo-5-[2-(4-trifluoromethyl-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-3-fluoro-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

(S)-2-{5-[2-(2-Fluoro-3-trifluoromethyl-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(S)-2-{5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-propionylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methoxy-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Bis-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-(2-Hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

N-[6-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2,4-Bis-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Fluoro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-4-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3,4-Dichloro-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Chloro-4-fluoro-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Chloro-2-fluoro-phenyl)-N-[2-(2-hydroxy-1,1-dimethyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[6-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide;

N-[6-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3,4-dichloro-phenyl)-acetamide;

N-[6-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide;

N-[6-Chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-fluoro-4-trifluoromethyl-phenyl)-acetamide;

(R)-2-{1-Oxo-5-[2-(2,3,4-trifluoro-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{-[2-(2,4-Bis-trifluoromethyl-phenyl)-acetylamino]-1-oxo-1H-isoquinolin-2-yl}-propionamide;

(R)-2-{1-Oxo-5-[2-(3,4,5-trifluoro-phenyl)-acetylamino]-1H-isoquinolin-2-yl}-propionamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[6-chloro-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[6-Chloro-2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide;

N-[6-Cyclopropyl-2-((R)-2-hydroxy-1-methyl-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-6-(2-hydroxy-ethylamino)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[6-Chloro-2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-fluoro-3-trifluoromethyl-phenyl)-acetamide;

N-[6-Chloro-2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(2-fluoro-3-trifluoromethyl-phenyl)-acetamide;

N-[2-(2-Acetylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-chloro-3-fluoro-phenyl)-acetamide;

N-[2-(2-Acetylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-chloro-4-fluoro-phenyl)-acetamide;

N-[2-(2-Acetylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3-fluoro-4-trifluoromethyl-phenyl)-acetamide;

N-[2-(2-Acetylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-chloro-3-trifluoromethyl-phenyl)-acetamide;

N-[2-(2-Acetylamino-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(3,4-difluoro-phenyl)-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(2-Fluoro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

N-[2-((R)-2-Hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-2-(4-trifluoromethyl-phenyl)-acetamide;

2-(4-Chloro-3-fluoro-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(4-Fluoro-3-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide;

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-(2-hydroxy-ethyl)-6-methyl-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide; and

2-(3-Fluoro-4-trifluoromethyl-phenyl)-N-[2-((R)-2-hydroxy-1-methyl-ethyl)-6-methyl-1-oxo-1,2,3,4-tetrahydro-isoquinolin-5-yl]-acetamide.

62 . A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of claim 1 .

63 . (canceled)

64 . (canceled)

65 . (canceled)

66 . A method for preventing, treating or ameliorating in a mammal a disease or condition that is causally related to the aberrant activity of the P2X 7 receptor in vivo, which comprises administering to the mammal an effective disease-treating or condition-treating amount of a compound according to claim 1 .

67 . The method of claim 66 , wherein the disease or condition is a pain condition.

68 . The method of claim 66 , wherein the disease or condition is an autoimmune disease.

69 . The method of claim 66 , wherein the disease or condition is an inflammatory disease or condition.

70 . The method of claim 66 , wherein the disease or condition is a neurological or neurodegenerative disease or condition.

71 . A method for preventing, treating or ameliorating in a mammal a disease or condition selected from: pain including acute, inflammatory and neuropathic pain, chronic pain, dental pain and headache including migraine, cluster headache and tension headache, Parkinson's disease, multiple sclerosis; diseases and disorders which are mediated by or result in neuroinflammation, traumatic brain injury and encephalitis; centrally-mediated neuropsychiatric diseases and disorders, depression mania, bipolar disease, anxiety, schizophrenia, eating disorders, sleep disorders and cognition disorders; epilepsy and seizure disorders; prostate, bladder and bowel dysfunction, urinary incontinence, urinary hesitancy, rectal hypersensitivity, fecal incontinence, benign prostatic hypertrophy and inflammatory bowel disease; respiratory and airway disease and disorders, allergic rhinitis, asthma and reactive airway disease and chronic obstructive pulmonary disease; diseases and disorders which are mediated by or result in inflammation, arthritis, rheumatoid arthritis and osteoarthritis, myocardial infarction, various autoimmune diseases and disorders, uveitis and atherosclerosis; itch/pruritus, psoriasis; obesity; lipid disorders; cancer; blood pressure; spinal cord injury; and renal disorders which comprises administering to the mammal an effective disease-treating or condition-treating amount of a compound according to claim 1 .

72 . The method of claim 71 , wherein the disease or condition is Parkinson's disease.

73 . The method of claim 71 , wherein the disease or condition is rheumatoid arthritis.

74 . The method of claim 71 , wherein the disease or condition is traumatic brain injury.

75 . The method of claim 71 , wherein the disease or condition is osteoarthritis.

76 . The method of claim 71 , wherein the disease or condition is pain.

77 . The method of claim 71 , wherein the disease or condition is neuropathic pain.

78 . A method of treating a mammal suffering from at least one symptom selected from the group consisting of symptoms of exposure to capsaicin, symptoms of burns or irritation due to exposure to heat, symptoms of burns or irritation due to exposure to light, symptoms of burns, bronchoconstriction or irritation due to exposure to tear gas, and symptoms of burns or irritation due to exposure to acid, which comprises administering to the mammal an effective disease-treating or condition-treating amount of a compound according to claim 1 .

79 . The method of claim 77 , wherein the pain is associated with a condition selected from the group consisting of postmastectomy pain syndrome, stump pain, phantom limb pain, oral neuropathic pain, Charcot's pain, toothache, venomous snake bite, spider bite, insect sting, postherpetic neuralgia, diabetic neuropathy, reflex sympathetic dystrophy, trigeminal neuralgia, osteoarthritis, rheumatoid arthritis, fibromyalgis, Guillain-Barre syndrome, meralgia paresthetica, burning-mouth syndrome, bilateral peripheral neuropathy, causalgia, sciatic neuritis, peripheral neuritis, polyneuritis, segmental neuritis, Gombault's neuritis, neuronitis, cervicobrachial neuralgia, cranial neuralgia, egniculate neuralgia, glossopharyngial neuralgia, migranous neuralgia, idiopathic neuralgia, intercostals neuralgia, mammary neuralgia, mandibular joint neuralgia, Morton's neuralgia, nasociliary neuralgia, occipital neuralgia, red neuralgia, Sluder's neuralgia splenopalatine neuralgia, supraorbital neuralgia, vidian neuralgia, sinus headache, tension headache, labor, childbirth, intestinal gas, menstruation, cancer, and trauma.

80 . (canceled)

81 . (canceled)

82 . (canceled)

83 . A compound according to claim 1 wherein the compound is selected from

2-(4-Chloro-phenyl)-N-[2-(2-hydroxy-ethyl)-1-oxo-1,2-dihydro-isoquinolin-5-yl]-acetamide,