Mitochondrial enhancement of cells
View Patent ↗Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of stem cells. Certain embodiments disclosed herein include, but are not limited to, methods of modifying stem cells, or methods of administering modified stem cells to at least one biological tissue.
1. A method, comprising: extracting DNA from the mitochondria of a first vertebrate cell, at least partially based on selecting the Major Histocompatibility type of the first vertebrate cell; and transferring the extracted mitochondrial DNA in vitro, as well as one or more of DNA from the cell nucleus or an entire cell nucleus, from the first vertebrate cell to a second vertebrate cell, wherein the first vertebrate cell and the second vertebrate cell are maternally genetically related to each other.
2. The method of claim 1 , wherein the mitochondrial DNA includes one or more mitochondrial chromosomes.
3. The method of claim 1 , wherein the mitochondrial DNA is selected by searching at least one database including information related to genotyped mitochondrial DNA.
4. The method of claim 1 , wherein the mitochondrial DNA is selected from a subject source of the first vertebrate cell that is chronologically younger in age than the subject source of the second vertebrate cell.
5. The method of claim 1 , wherein the mitochondrial DNA is selected at least partially based on the number of mutations in the mitochondrial DNA as determined by a peptide nucleic acid oligomer probe.
6. The method of claim 1 , wherein the mitochondrial DNA from the first vertebrate cell is transferred to at least one intracellular target of the second vertebrate cell.
7. The method of claim 6 , wherein the at least one intracellular target includes at least one of a nucleolus, nucleus, ribosome, vesicle, rough endoplasmic reticulum, Golgi apparatus, cytoskeleton, smooth endoplasmic reticulum, mitochondria, vacuole, cytoplasm, lysosome, or centriole.