Systems, devices, and methods including implantable devices with anti-microbial properties
Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.
1 . A insertable device, comprising:
a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;
one or more anti-microbial regions including at least one D-amino acid coating on at least one of the outer surface, inner surface, or embedded in the body structure.
2 . (canceled)
3 . The insertable device of claim 1 , wherein at least one of the anti-microbial regions is actuatable.
4 .- 15 . (canceled)
16 . The insertable device of claim 1 , further comprising at least one light source.
17 .- 48 . (canceled)
49 . The insertable device of claim 1 , wherein at least one of the anti-microbial regions includes at least one electroactive polymer.
50 .- 52 . (canceled)
53 . The insertable device of claim 1 , wherein the body structure further includes at least one porous material.
54 . The insertable device of claim 1 , wherein at least one of the plurality of anti-microbial regions includes at least one porous material.
55 . The insertable device of claim 54 , wherein the at least one porous material is configured to capture at least one microorganism proximate to at least one of the inner surface or the outer surface of the body structure.
56 .- 60 . (canceled)
61 . The insertable device of claim 1 , further comprising at least one sensor.
62 . The insertable device of claim 61 , wherein the at least one sensor is configured to detect a microbial component proximate the body structure.
63 .- 73 . (canceled)
74 . The insertable device of claim 1 , further comprising a power source.
75 .- 76 . (canceled)
77 . The insertable device of claim 74 , wherein the power source comprises at least one rechargeable power source.
78 .- 79 . (canceled)
80 . The insertable device of claim 1 , further comprising at least one of a battery, capacitor, or a mechanical energy store.
81 . The insertable device of claim 1 , further comprising a power receiver configured to receive power from an ex vivo power source.
82 . The insertable device of claim 1 , further comprising a power receiver configured to receive power from an in vivo power source.
83 . (canceled)
84 . The insertable device of claim 1 , further comprising at least one active agent reservoir configured to release at least one active agent to at least one of the outer surface or inner surface of the body structure.
85 . (canceled)
86 . The insertable device of claim 84 , further comprising a release system.
87 . The insertable device of claim 84 , further comprising control circuitry configured for selectively opening at least a portion of the at least one active agent reservoir.
88 .- 91 . (canceled)
92 . The insertable device of claim 1 , further comprising a processor to control activation of at least one anti-microbial region.
93 . The insertable device of claim 92 , wherein the processor is configured to be responsive to the at least one sensor.
94 . A insertable device, comprising:
a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;
one or more selectively actuatable anti-microbial regions including at least one anti-microbial reservoir including at least one D-amino acid, and directed to deliver at least one D-amino acid to at least one of the outer surface, inner surface, or internal body structure.
95 .- 96 . (canceled)
97 . The insertable device of claim 94 , wherein the at least one anti-microbial coating is configured for time-release of at least one anti-microbial agent.
98 .- 99 . (canceled)