DEVICES FOR MAINTAINING SURGICALLY CREATED OPENINGS
Devices and methods are directed to improving the gaseous exchange in a lung of an individual having, for instance, chronic obstructive pulmonary disease. More particularly, conduits may be deployed in the lung to maintain collateral openings (or channels) surgically created through airway walls. This tends to facilitate both the exchange of oxygen ultimately into the blood and decompress hyper-inflated lungs. The conduit includes a radially expandable center section having a first end, a second end, and a passageway extending from the first end to the second end. A control segment may be associated with the conduit to limit the degree of radial expansion. The conduit further includes a plurality of deflectable members extending from the ends of the center section. A tissue barrier may coaxially surround the conduit such that tissue ingrowth is prevented. The conduits may also include hold-down members and bioactive coatings that serve to prevent ejection of the conduit as well as prevent narrowing of the passageway due to tissue ingrowth.
1 . A method of treating diseased lung tissue in a lung, the method comprising:
advancing a delivery catheter through a natural respiratory opening and into the lung;
advancing the delivery catheter through an extra-anatomic opening in an airway wall at a target site where the extra-anatomic opening is patent such that the catheter may enter the channel without creating an additional opening in the airway wall; and
delivering a substance through the extra-anatomic opening to treat a region of diseased tissue beyond the airway wall in the lung.
2 . The method of claim 1 , where the substances or drugs are selected from a group consisting of pyrolitic carbon, titanium-nitride-oxide, paclitaxel, fibrinogen, collagen, thrombin, phosphorylcholine, heparin, rapamycin, radioactive 188Re and 32P, silver nitrate, dactinomycin, sirolimus, cell adhesion peptide
3 . The method of claim 1 , where the extra-anatomic opening extends at least into the parenchyma.
4 . The method of claim 1 , where lung includes a plurality of extra-anatomic openings and advancing the delivery catheter comprises advancing the delivery catheter through at least one extra-anatomic opening.
5 . The method of claim 1 , where the extra-anatomic opening contains a conduit.
6 . A method of treating diseased lung tissue in a lung, the method comprising:
advancing a catheter through a natural respiratory opening and into the lung;
advancing the catheter through an extra-anatomic opening in an airway wall at a target site where the extra-anatomic opening is patent such that the catheter may enter the channel without creating an additional opening in the airway wall; and
treating a region of diseased tissue beyond the airway wall in the lung.
7 . The method of claim 6 where the treatment device is a needle.
8 . The method of claim 6 where the treatment device is a radio-frequency energy ablation catheter.