Devices for delivering substances through an extra-anatomic opening created in an airway
View Patent ↗Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.
1. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:
advancing a catheter through a natural respiratory opening and into the lung;
advancing the catheter through the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall; and
treating the treatment site using the catheter.
2. The method of claim 1 , wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.
3. The method of claim 2 , wherein the step of delivering the substance through the existing artificially created opening comprises delivering the substance through the existing artificially created opening to treat a tumor.
4. The method of claim 2 , wherein the substance comprises a substance selected from the group consisting of antimetabolites, antithrobotics, anticoagulants, antiplatelet agents, thorombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, agents that inhibit restenosis, anti-angiogenic agents or angiogenesis inhibitors, smooth muscle cell inhibitors, growth factors, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters and a combination thereof.
5. The method of claim 1 , further comprising preventing closure of the existing artificially created opening wherein said preventing step is performed using a mechanical means.
6. The method of claim 5 , wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant within and b) dilating the existing artificially created opening.
7. The method of claim 1 , further comprising creating the existing artificially created opening.
8. The method of claim 1 wherein the catheter comprises a rounded distal end.
9. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:
advancing a catheter through a natural respiratory opening and into the lung;
advancing a rounded end of the catheter through the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall; and
treating the treatment site using the catheter.
10. The method of claim 9 , wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.
11. The method of claim 10 , wherein the step of delivering the substance through the existing artificially created opening comprises delivering the substance through the existing artificially created opening to treat a tumor.
12. The method of claim 10 , further comprising creating the existing artificially created opening.
13. The method of claim 9 , further comprising preventing closure of the existing artificially created opening wherein said preventing step is performed using a mechanical means.
14. The method of claim 13 , wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant within and b) dilating the existing artificially created opening.
15. A method of treating lung tissue through an existing artificially created opening in an airway wall, the method comprising:
advancing a catheter through a natural respiratory opening and into the lung;
creating an artificial opening through the airway wall with a piercing member;
enlarging the artificial opening;
advancing a rounded end of the catheter into the existing artificially created opening in the airway wall to access a treatment site in lung tissue beyond the airway wall;
preventing closure of the artificially created opening; and
treating the treatment site using the catheter.
16. The method of claim 15 , wherein treating the treatment site using the catheter comprises delivering a substance through the existing artificially created opening to treat a region of diseased tissue beyond the airway wall in the lung.
17. The method of claim 15 , further comprising delivering electrical energy with the catheter.
18. The method of claim 15 , wherein preventing closure of the artificially created opening is performed using a mechanical means.
19. The method of claim 18 , wherein said mechanical means comprises an act selected from the group consisting of a) inserting an implant in the artificially created opening, b) dilating the artificially created opening, and c) temporarily holding open the artificially created opening with an instrument.
20. The method of claim 15 , wherein said piercing member is withdrawn from the opening prior to advancing the rounded end of the catheter.