Cartilage composition and process for producing the cartilage composition
View Patent ↗Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.
1. A particulate cartilage composition for stimulating chondrogenesis and producing cartilage regeneration consisting of non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from 60 microns to 500 microns, wherein the particulate cartilage when packed densely into a cartilage defect and compacted enhances regeneration of the articular cartilage within the defect.
2. The particulate cartilage composition of claim 1 , wherein the non-demineralized particulate articular cartilage has a distribution of particle sizes within the range of 60 microns to 250 microns.
3. The particulate cartilage composition of claim 1 , wherein the non-demineralized particulate articular cartilage is chemically untreated non-demineralized particulate articular cartilage.
4. The particulate cartilage composition of claim 1 , wherein the non-demineralized particulate articular cartilage is one of hyaline cartilage, fibrocartilage, and mixtures thereof.
5. The particulate cartilage composition of claim 1 , wherein the non-demineralized articular cartilage is one of allogeneic cartilage, xenogeneic cartilage, and mixtures thereof.
6. A process for preparing the particulate cartilage composition of claim 1 for stimulating chondrogenesis and producing cartilage regeneration comprising grinding non-demineralized articular cartilage to particle sizes distributed within the range of from 60microns to 500 microns, wherein, during grinding, the temperature of the non-demineralized articular cartilage does not exceed about 50° C.
7. The process of claim 6 , wherein, during grinding, the temperature of the non-demineralized articular cartilage does not exceed about 40° C.
8. The process of claim 6 , wherein the non-demineralized articular cartilage is not chemically treated.
9. The process of claim 6 , wherein the process comprises grinding one of dry non-demineralized articular cartilage, freeze-dried non-demineralized articular cartilage, frozen non-demineralized articular cartilage, wet non-demineralized articular cartilage, and mixtures thereof.
10. The process of claim 6 , which comprises grinding one of non-demineralized allogeneic cartilage, non-demineralized xenogeneic cartilage, and mixtures thereof.