Use of anti-bacterial agents for the treatment of epithelial-related conditions
View Patent ↗Disclosed herein are methods of inactivating and/or decolonizing bacteria on a surface. The present invention also discloses methods for treatment of epithelial conditions caused or aggravated by bacteria, such as acne vulgaris, in a subject in need thereof. The present invention additionally discloses inventive compounds and compositions that exhibit anti-bacterial and/or anti-inflammatory effects.
1. A method comprising steps of:
administering an anti-bacterial agent to a subject suffering from acne vulgaris caused or aggravated by Propionibacterium acnes , said anti-bacterial agent comprising an effective amount of a compound represented by the formula:
or a pharmaceutically acceptable salt thereof;
wherein the effective amount of the compound exhibits an anti-bacterial activity, which results in an IC50 against Propionibacterium acnes of between 0.5 μg/mL and about 300 μg/mL.
2. The method according to claim 1 , wherein administration is topical.
3. The method according to claim 1 , wherein administration is by inhalation.
4. The method according to claim 1 , wherein administration is parenteral.
5. A method comprising steps of:
inhibiting Propionibacterium acnes growth on a surface of an animal or Propionibacterium acnes decolonization on a surface of an animal comprising administering to a surface of the animal an effective amount of an anti-bacterial agent comprising a compound represented by the formula:
or a pharmaceutically acceptable composition thereof;
wherein the effective amount of the compound results in an IC50 against Propionibacterium acnes of about 0.5 μg/mL to about 300 μg/mL.
6. The method of claim 1 , wherein the effective amount is about 10 μg/kg to about 50 mg/kg.
7. The method of claim 1 , wherein the effective amount is about 0.2 mg/20 uL to about 0.8 mg/20 uL.
8. A method comprising steps of:
administering a topical acne composition to a subject suffering from acne vulgaris caused or aggravated by Propionibacterium acnes , wherein said composition comprises an effective amount of a compound represented by the formula:
or a pharmaceutically acceptable salt thereof, the compound exhibits both anti-bacterial activity and anti-inflammatory activity and
wherein the effective amount of the compound exhibits an anti-bacterial activity, which results in an IC50 against Propionibacterium acnes of between 0.5 μg/mL and about 300 μg/mL.