Methods and compositions for treating symptoms associated with post-traumatic stress disorder using cyclobenzaprine

1. A method for treating post-traumatic stress disorder (PTSD) following a traumatic event, comprising: administering to a human in need of such treatment a pharmaceutical composition comprising cyclobenzaprine in a therapeutically effective amount and a therapeutically effective carrier, wherein such treatment eliminates or ameliorates the PTSD.

2. The method of claim 1 , wherein the amount of cyclobenzaprine administered is between 0.1 mg and 50 mg/day.

3. The method of claim 2 , wherein the amount of cyclobenzaprine administered is between 0.5 mg and 30 mg/day.

4. The method of claim 3 , where the amount of cyclobenzaprine administered is between 1 mg and 20 mg/day.

5. The method of claim 1 , wherein the amount of cyclobenzaprine administered is less than 5 mg/day.

6. The method of claim 5 , wherein the amount of cyclobenzaprine administered is less than 2.5 mg/day.

7. The method of claim 1 , wherein the method further comprises administering sequentially or concurrently a drug selected from the group consisting of an alpha-1-adrenergic receptor antagonist, a beta-adrenergic antagonist, an anticonvulsant, a selective serotonin reuptake inhibitor and a serotonin-norepinephrine reuptake inhibitor.

8. The method of claim 7 , wherein the alpha-1-adrenergic receptor antagonist is prazosin.

9. The method of claim 8 , wherein the selective serotonin reuptake inhibitor is sertraline, paroxetine, fluoxetine, citalopram or escitalopram.

10. The method of claim 1 , wherein the pharmaceutical composition is administered as an orally dissolving tablet or as a thin film formulation.

11. The method of claim 1 , wherein the pharmaceutical composition is administered in combination with psychotherapeutic intervention.