Phenylalanine derivatives

1. A compound of formula (1):

wherein:

A represents a group of formula (3-1):

wherein Arm represents a cyclic alkyl group or an aromatic ring containing 0, 1, 2, 3, or 4 hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen atoms;

U and V independently represent C(═O), S(═O) 2 , C(—R5)(—R6), C(═C(R5)(R6)), C(═S), S(═O), P(═O)(—OH) or P(—H)(═O);

R2, R3, R4, R5, and R6 may be the same or different from one another and each represent a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a substituted lower alkyl group, a lower alkenyl group, a substituted lower alkenyl group, a lower alkynyl group, a substituted lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxyl group, a lower alkylthio group, a lower alkoxyl group and lower alkylthio group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxyl group and lower alkylthio group substituted with an aryl group(s), a lower alkoxyl group and lower alkylthio group substituted with a heteroaryl group(s), a cycloalkyloxy group which may contain a hetero atom(s) in the ring thereof, an aryloxy group, a heteroaryloxy group, a lower hydroxyalkyl group, a lower hydroxyalkenyl group, a lower hydroxyalkoxyl group, a lower halogenoalkyl group. a lower halogenoalkoxyl group, a lower halogenoalkylthio group, a lower halogenoalkenyl group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a substituted or unsubstituted sulfamoyl group or an ammonium group, R5 and R6 may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms

B represents hydroxyl group, a lower alkoxyl group or hydroxylamino group;

C represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s) or a lower alkyl group substituted with a heteroaryl group(s);

D represents a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group which may contain a hetero atom(s) in the ring thereof, an aryl group, a heteroaryl group, a lower alkyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkyl group substituted with an aryl group(s), a lower alkyl group substituted with a heteroaryl group(s), a lower alkoxyl group, a lower alkoxyl group substituted with a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, a lower alkoxyl group substituted with an aryl group(s), a lower alkoxyl group substituted with a heteroaryl group(s), a cycloalkyloxy group which may contain a hetero atom(s) in the ring thereof, an aryloxy group, a heteroaryloxy group, a lower hydroxyalkyl group, a lower hydroxyalkenyl group, a lower hydroxyalkoxyl group, a lower halogenoalkyl group, a lower halogenoalkoxyl group, a lower halogenoalkenyl group, nitro group, cyano group, a substituted or unsubstituted amino group, carboxyl group, a lower alkyloxycarbonyl group, a substituted or unsubstituted carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylthio group, a lower alkylsulfonyl group or a substituted or unsubstituted sulfamoyl group;

C and D may be bonded together to form a ring which may contain one or two oxygen, nitrogen or sulfur atoms;

T represents an interatomic bond, C(═O), C(═S), S(═O), S(═O) 2 , N(H)—C(═O), or N(H)—C(═S);

J and J′ may be the same or different from each other and each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkyloxy group or a nitro group;

or a pharmaceutically acceptable salt thereof.

2. A compound or pharmaceutically acceptable salt according to claim 1 , wherein Arm represents a benzene ring.

3. A compound or pharmaceutically acceptable salt according to claim 1 , wherein R2, R3, and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a substituted lower alkyl group, a lower alkoxyl group, a halogen lower alkyl group, substituted or unsubstituted amino group, or an ammonium group.

4. A compound or pharmaceutically acceptable salt according to claim 1 , wherein B represents hydroxyl group or a lower alkoxyl group.

5. A compound or pharmaceutically acceptable salt according to claim 1 , wherein C represents a hydrogen atom or a lower alkyl group.

6. A compound or pharmaceutically acceptable salt according to claim 1 , wherein D represents a a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, an aryl group, or a heteroaryl group.

7. A compound or pharmaceutically acceptable salt according to claim 1 , wherein J and J′ each represent a hydrogen atom.

8. A compound or pharmaceutically acceptable salt according to claim 1 , wherein T represents C(═O).

9. A compound or pharmaceutically acceptable salt according to claim 1 , wherein U and V independently represent C(═O) or C(═S).

10. A compound or pharmaceutically acceptable salt according to claim 1 , wherein U and V are both C(═O).

11. A compound or pharmaceutically acceptable salt according to claim 1 , wherein:

Arm represents a benzene ring;

R2, R3, and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a substituted lower alkyl group, a lower alkoxyl group, a halogen lower alkyl group, substituted or unsubstituted amino group, or an ammonium group;

B represents hydroxyl group or a lower alkoxyl group;

C represents a hydrogen atom or a lower alkyl group;

D represents a a cycloalkyl group(s) which may contain a hetero atom(s) in the ring thereof, an aryl group, or a heteroaryl group;

J and J′ each represent a hydrogen atom;

T represents C(═O); and

U and V independently represent C(═O) or C(═S).

12. A compound or pharmaceutically acceptable salt according to claim 11 , wherein U and V are both C(═O).