Methods for the diagnosis and treatment of lung cancer
View Patent ↗The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.
1. A method of aiding in the diagnosis of lung cancer in a human patient, said method comprising:
(a) detecting the presence of an overexpressed proto-oncogene encoding 8-oxo-dGTPase in a lung cell sample taken from the patient; and
(b) determining that there is an indication of the presence of lung cancer in the patient when the proto-oncogene is overexpressed.
2. The method of claim 1 , wherein the presence of the overexpressed proto-oncogene is determined by detecting the quantity of mRNA transcribed from the proto-oncogene.
3. The method of claim 1 , wherein the detecting is determined by probing the sample with a probe or primer comprising the sequence TGGCCCGACG (SEQ. ID No.3) or its complement.
4. The method of claim 2 , wherein the presence of the overexpressed proto-oncogene is determined by detecting the quantity of cDNA produced from the reverse transcription of the mRNA.
5. The method of claim 1 , wherein the presence of the overexpressed proto-oncogene is determined by detecting the quantity of the polypeptide or protein encoded by the proto-oncogene.
6. The method of claim 5 , wherein the lung cancer is non-small cell lung cancer.