Sirtuin modulating compounds
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
1. A method for ameliorating at least one symptom of insulin resistance, metabolic syndrome, diabetes, or for increasing insulin sensitivity in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.
2. A method for reducing the weight of a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.
3. A method for enhancing motor performance or muscle endurance, decreasing fatigue, or increasing recovery from fatigue, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.
4. A method for ameliorating at least one symptom of a condition wherein motor performance or muscle endurance is reduced, wherein the condition is one or more of age-related muscle wasting, and muscle atrophy or cachexia associated with burns, bed rest, limb immobilization, or a major thoracic, abdominal, and/or orthopedic surgery, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.
5. A method for ameliorating at least one symptom of muscle tissue damage associated with hypoxia or ischemia, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.
6. A method for increasing muscle ATP levels in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
each of X 7 , X 8 , X 9 and X 10 is independently selected from N, CR 20 , or CR 1 ′, wherein:
each R 20 is independently selected from H or a solubilizing group;
each R 1 ′ is independently selected from H or optionally substituted C 1 -C 3 straight or branched alkyl, wherein when R 1 ′ is substituted, R 1 ′ is substituted with one or more of —OH, halogen, —OR a , —O—COR a , —COR a , —C(O)R a , —CN, —NO 2 , —COOH, —COOR a , —OCO 2 R a , —C(O)NR a R b , —OC(O)NR a R b , —SO 3 H, —NH 2 , —NHR a , —N(R a R b ), —COOR a , —CHO, —CONH 2 , —CONHR a , —CON(R a R b ), —NHCOR a , —NRCOR a , —NHCONH 2 , —NHCONR a H, —NHCON(R a R b ), —NR c CONH 2 , —NR c CONR a H, —NR c CON(R a R b ), —C(═NH)—NH 2 , —C(═NH)—NHR a , —C(═NH)—N(R a R b ), —C(═NR c )—NH 2 , —C(═NR c )—NHR a , —C(═NR c )—N(R a R b ), —NH—C(═NH)—NHR a , —NH—C(═NH)—N(R a R b ), —NH—C(═NR c )—NH 2 , —NH—C(═NR c )—NHR a , —NH—C(═NR c )—N(R a R b ), —NR d —C(═NH)—NH 2 , —NR d —C(═NH)—NHR a , —NR d —C(═NH)—N(R a R b ), —NR d —C(═NR c )—NH 2 , —NR d —C(═NR c )—NHR a , —NR d —C(═NR c )—N(R a R b ), —NHNH 2 , —NHNHR a , —SO 2 NH 2 , —SO 2 NHR a , —SO 2 NR a R b , —CH═CHR a , —CH═CR a R b , —CR c ═CR a R b , CR c ═CHR a , —CR c ═CR a R b , —CCR a , —SH, —SO k R a , —S(O) k OR a and —NH—C(═NH)—NH 2 , wherein
k is 0, 1 or 2;
R a -R d are each independently an aliphatic, substituted aliphatic, benzyl, substituted benzyl, aromatic or substituted aromatic group; and
—NR a R b , taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group;
wherein a non-aromatic heterocyclic group, benzylic group or aryl group can also have an aliphatic or substituted aliphatic group as a substituent; a substituted aliphatic group can also have a non-aromatic heterocyclic ring, a substituted non-aromatic heterocyclic ring, benzyl, substituted benzyl, aryl or substituted aryl group as a substituent; and a substituted aliphatic, non-aromatic heterocyclic group, substituted aryl, or substituted benzyl group can have more than one substituent;
one of X 7 , X 8 , X 9 and X 10 is N and the others are selected from CR 20 or CR 1 ′; and
zero to one R 20 is a solubilizing group;
R 19 is selected from:
wherein:
each Z 10 , Z 11 , Z 12 and Z 13 is independently selected from N, CR 20 , or CR 1 ′; and
each Z 14 , Z 15 and Z 16 is independently selected from N, NR 1 ′, S, O, CR 20 , or CR 1 ′,
wherein:
zero to two of Z 10 , Z 11 , Z 12 and Z 13 are N;
at least one of Z 14 , Z 15 and Z 16 is N, NR 1 ′, O or S;
zero to one of Z 14 , Z 15 and Z 16 is S or O;
zero to two of Z 14 , Z 15 and Z 16 are N or NR 1 ′;
zero to one R 20 is a solubilizing group;
zero to one R 1 ′ is an optionally substituted C 1 -C 3 straight or branched alkyl; and
R 21 is selected from —NR 1 ′—C(O)—, —NR 1 ′—S(O) 2 —, —NR 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—NR 1 ′—, —NR 1 ′—C(═NR 1 ′)—NR 1 ′—, —C(O)—NR 1 ′—, —C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—, —CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—, —NR 1 ′—S(O) 2 —NR 1 ′—, —NR 1 ′—C(O)—NR 1 ′—S(O) 2 —, —NR 1 ′—CR 1 ′R 1 ′—C(O)—NR 1 ′—, —CR 1 ′R 1 ′—C(O)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′═CR 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(═N—CN)—NR 1 ′—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—O—, —NR 1 ′—C(O)—CR 1 ′R 1 ′—CR 1 ′R 1 ′—O—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—, —NR 1 ′—S(O) 2 —CR 1 ′R 1 ′—CR 1 ′R 1 ′—, —NR 1 ′—C(O)—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(S)—NR 1 ′—CR 1 ′R′ 1 —CR 1 ′R′ 1 —, —NR 1 ′—C(O)—O— or —NR 1 ′—C(O)—CR 1 ′R 1 ′—; and
R 31 is selected from an optionally substituted monocyclic or bicyclic aryl, or an optionally substituted monocyclic or bicyclic heteroaryl, with the proviso that when R 19 is
Z 10 , Z 11 , Z 12 and Z 13 are each CH, and R 21 is —NHC(O)—, R 31 is not an optionally substituted phenyl.