Thiazole derivatives
View Patent ↗Wherein n is an integer of from 0 to 3; R 1A is a 5-membered aromatic heterocyclic group containing at least one oxygen atom; R 2A is —COR 8 (wherein R 8 is aryl); R 3A is hydrogen or lower alkyl; and R 12 represents cycloalkyl, aryl, aralkyl, alicyclic heterocyclic group, aromatic heterocyclic group, alicyclic hetocyclic-alkyl, or aromatic heterocyclic-alkyl, and R 1A , R 2A , R 3A and R 12 are individually optionally substituted.
1. A thiazole derivative represented by formula (IA):
wherein
R 1A represents a substituted or unsubstituted 5-membered aromatic heterocyclic group containing at least one oxygen atom;
n represents an integer of from 0 to 3;
R 12 represents substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, a substituted or unsubstituted alicyclic heterocyclic group, a substituted or unsubstituted aromatic heterocyclic group, substituted or unsubstituted alicyclic heterocyclic-alkyl, or substituted or unsubstituted aromatic heterocyclic-alkyl;
R 3A represents a hydrogen atom, or substituted or unsubstituted lower alkyl; and
R 2A represents —COR 8 (wherein R 8 represents a substituted or unsubstituted aryl);
or a pharmaceutically acceptable salt thereof.
2. The thiazole derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1A is substituted or unsubstituted furyl.
3. The thiazole derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein n is 0.
4. The thiazole derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 3A is a hydrogen atom.
5. The thiazole derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 3A is lower alkyl.
6. The thiazole derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1A is furyl.
7. The thiazole derivative according to claim 6 or a pharmaceutically acceptable salt thereof, wherein n is 0.
8. The thiazole derivative according to claim 7 or a pharmaceutically acceptable salt thereof, wherein R 3A is a hydrogen atom.
9. The thiazole derivative according to claim 8 or a pharmaceutically acceptable salt thereof, wherein R 12 is substituted or unsubstituted phenyl.
10. The thiazole derivative according to claim 8 or a pharmaceutically acceptable salt thereof, wherein R 12 is substituted or unsubstituted alicyclic heterocyclic group.
11. The thiazole derivative according to claim 8 or a pharmaceutically acceptable salt thereof, wherein R 12 is substituted or unsubstituted aromatic heterocyclic group.
12. A thiazole derivative represented by any of the following formulae (99), (149) or (170), or a pharmaceutically acceptable salt thereof