Self-assembling hydrogels based on dicephalic peptide amphiphiles
View Patent ↗We have disclosed dicephalic amphiphiles having peptide sequences as the head groups. We have also disclosed self-assembly hydrogels prepared from the dicephalic peptide amphiphiles. These hydrogels are useful for the encapsulation and delivery of bioactives to a patient.
1. A dicephalic peptide amphiphile comprising the formula:
wherein n is equal to at least 6 and X is one of the peptide sequences selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO:13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16 and SEQ ID NO: 17.
2. The dicephalic peptide amphiphile of claim 1 wherein n is in the range of 6 to about 22.
3. The dicephalic peptide amphiphile of claim 2 wherein n is in the range of about 12 to about 18.
4. A hydrogel comprising the dicephalic peptide amphiphile of claim 1 .