Substituted 8-[6-amino-3-pyridyl]xanthines
View Patent ↗The present invention provides substituted 8-[6-amino-3-pyridyl]xanthines such as the following: and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
1. A compound selected from the group:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of compound 50 or 51 of claim 1 ; and
(b) a pharmaceutically acceptable excipient.
3. A method for inhibiting the activity of Adenosine A 2B receptors in a mammal comprising administering to the mammal an effective amount of compound 50 or 51 of claim 1 .
4. A method for treating asthma comprising administering an effective amount of compound 50 or 51 of claim 1 to a mammal in need of such treatment.
5. A method for treating diabetic retinopathy comprising administering an effective amount of compound 50 or 51 of claim 1 or a pharmaceutically acceptable salt thereof to a mammal in need of such treatment.