Preparations and methods for ameliorating or reducing presbyopia
View Patent ↗This application relates to the use of one or more parasympathomimetic drugs in combination with one or more alpha agonists to create optically beneficial miosis to, for example, temporarily treat presbyopia. The invention provides a pharmaceutical preparation comprising a therapeutically effective amount of one or more parasympathomimetic drugs or cholinesterase inhibitors, or a pharmaceutically acceptable salt thereof, in combination with one or more alpha agonists or antagonists, or a pharmaceutically acceptable salt thereof. The invention further provides for a method for treating, ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye a pharmaceutically effective amount of the ophthalmic preparation.
1. A method for ameliorating or reducing presbyopia of a patient having an eye, comprising administering to said eye a therapeutically effective amount of an ophthalmic topical preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%.
2. The method of claim 1 , wherein pilocarpine is present in an amount of 1% and brimonidine is present in an amount of 0.20%.
3. A method of producing ocular miosis in a subject under normal light conditions which comprises administering to the subject an amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or pharmaceutically acceptable salts thereof, in an amount of 0.05-0.2% effective to produce ocular miosis.
4. A method of ameliorating, reducing or eliminating dimness of vision of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0. 25-1.0% and brimonidine or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%.
5. A method of improving focus and/or correcting refractive errors of a patient having an eye comprising administering to said eye a therapeutically effective amount of an ophthalmic preparation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0. 25-1.0% and brimonidine, or pharmaceutically acceptable salts thereof in an amount of 0.05-0.2%.
6. A method of treating presbyopia in a patient in need of treatment thereof comprising administering an effective amount of an ophthalmic topical preparation comprising a therapeutically effective amount pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount of 0.25-1.0% and brimonidine, or a pharmaceutically acceptable salt thereof in an amount of 0.05-0.2%. to a single eye of a patient thereby leaving the other eye untreated.