Pumping devices, systems and methods for use with medical fluids including compensation for variations in pressure or flow rate

1. A system for delivery of a medical fluid to a patient comprising:

a pump system comprising a pressurizing unit to pressurize the medical fluid and a drive system in operative connection with the pressurizing unit, the pump system exhibiting a variation in pressure during operation; and

a compensating system in fluid connection with the medical fluid pressurized by the pressurizing unit, the compensating system defining a chamber having a displacement volume in fluid connection with the pressurized medical fluid wherein the displacement volume is altered to alter the variation in pressure, the compensating system comprising a piston that is reciprocally moveable within the chamber to alter the displacement volume of the chamber, a first end of the piston of the compensating system being in operative connection with a drive mechanism adapted to actively move the piston of the compensating system in a manner dependent upon timing of actuation of the pressurizing unit, a second end of the piston of the compensating system being biased against the force of the pressurized medical fluid by a compressible biasing mechanism having a predetermined compressibility, wherein the piston of the compensating system is actively moved by the drive mechanism against the biasing force of the compressible biasing mechanism to reduce pulsatility of the pressurized medical fluid over a range of fluid pressure within the operating pressure range of the pump system.

2. The system of claim 1 , wherein the pressurizing unit comprises a plurality of actuatable pressurizing members and the compensating system reduces pulsatility of the pressurized medical fluid during flow resulting from timed actuation of the plurality of pressurizing members.

3. The system of claim 2 , wherein the plurality of actuatable pressurizing members comprise a plurality of pistons.

4. The system of claim 1 , wherein the compressible biasing mechanism is a spring.

5. The system of claim 3 , wherein the plurality of actuatable pressurizing members are actuated in a timed manner by the drive system, and wherein the drive mechanism moves the piston of the compensating system in a manner dependent upon a timing of actuation of the plurality of actuatable pressurizing members.

6. The system of claim 5 , wherein the drive system comprises a multi-lobed cam element that is rotated to time movement of each of the plurality of actuatable pressurizing members.

7. The system of claim 6 , wherein a number of lobes of the multi-lobed cam element is determined by a number of the plurality of actuatable pressurizing members.

8. The system of claim 7 , wherein the pump system comprises a rotatable timing shaft to actuate the plurality of actuatable pressurizing members in the timed manner and wherein the multi-lobed cam element is coupled to the rotatable timing shaft.

9. The system of claim 8 , wherein the piston of the compensating system is slidably positioned within a chamber and forms a sealing engagement with an inner wall of the chamber.

10. The system of claim 9 , wherein a rearwardmost position of the piston of the compensating system is adjustable within the chamber to adjust an extent to which the piston can alter the displacement volume.

11. The system of claim 10 , wherein the compressible biasing mechanism is a spring.

12. The system of claim 10 , further comprising an abutment element to abut the piston of the compensating system and to adjust the rearwardmost position of the piston.

13. The system of claim 1 , wherein the compensating system further comprises a second piston slidably positioned within a second chamber and forming a sealing engagement with an inner wall of the second chamber, and an actuator system to control position of the second piston within the second chamber, the actuator system being in communicative connection with a control system.

14. The system of claim 1 , wherein the compensating system is in fluid connection with an outlet channel within the pressurizing unit.

15. The system of claim 1 , wherein the pressurizing unit is removable from connection with the drive system.