Bone graft materials and methods
View Patent ↗Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.
1. A bone graft composition comprising: about 15% to about 20% by weight collagen; about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate, wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft composition, and wherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm.
2. The bone graft composition of claim 1 , wherein said collagen is medical grade type I collagen.
3. The bone graft composition of claim 1 , wherein said calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite.
4. The bone graft composition of claim 3 , further comprising about 15% by weight medical grade type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate.
5. The bone graft composition of claim 4 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively.
6. The bone graft composition of claim 4 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively.
7. The bone graft composition of claim 4 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively.
8. A bone graft composition, comprising: an uncompressed collagen, the collagen comprising about 15% by weight of the bone graft composition; a plurality of bioactive glass particles dispersed throughout the collagen, at least 85% of the plurality of bioactive glass particles within a range of 212 μm to about 425 μm, the plurality of bioactive glass particles comprising about 60% by weight of the bone graft composition; and a calcium phosphate dispersed throughout the collagen and the calcium phosphate material comprising about 20% to 30% by weight of the bone graft composition.
9. The bone graft composition of claim 8 , wherein the calcium phosphate is 25% to 30% by weight of the bone graft composition.
10. The bone graft composition of claim 8 , wherein the calcium phosphate is 30% by weight of the bone graft composition.
11. A bone graft composition, comprising: a collagen matrix; and a plurality of bioactive glass particulates dispersed throughout said collagen matrix, at least 85% of the plurality of bioactive glass particulates having a size within a range of 212 μm to about 425 μm; wherein said collagen matrix is about 20% to about 60% by weight of the bone graft composition and said bioactive glass is about 40% to about 80% by weight of the bone graft composition.
12. The bone graft composition of claim 11 , wherein said collagen matrix is uncompressed.
13. The bone graft composition of claim 11 , further comprising:
a calcium phosphate dispersed throughout said collagen matrix, the calcium phosphate is 25% to 30% by weight of the bone graft composition;
the plurality of bioactive glass particulates are 50% by weight of the bone graft composition.
14. The bone graft composition of claim 13 , wherein the collagen is about 20% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 80% by weight of the bone graft composition.
15. The bone graft composition of claim 13 , wherein the collagen is about 40% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 60% by weight of the bone graft composition.
16. The bone graft composition of claim 13 , wherein the collagen is about 60% by weight of the bone graft composition and the plurality of bioactive glass particulates is about 40% by weight of the bone graft composition.
17. The bone graft composition of claim 11 , wherein the collagen and the plurality of bioactive glass particulates collectively comprise 100% by weight of the bone graft composition.
18. A method of making a porous bone graft material of claim 1 , comprising the steps of:
a) mixing a collagen with bioactive glass particles and calcium phosphate; and
b) lyophilizing the mixture of said collagen, bioactive glass particles, and calcium phosphate to form a porous bone graft material,
wherein the lyophilized bone graft material is about 15% to about 20% by weight collagen;
about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate,
wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft material, and
wherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm.
19. The method of claim 18 , wherein said collagen is type I collagen.
20. The method of claim 18 , wherein said calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite.
21. The method of claim 20 , further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate.
22. The method of claim 21 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:55%:30%, respectively.
23. The method of claim 21 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:60%:25%, respectively.
24. The method of claim 21 , wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:65%:20%, respectively.
25. A method of making bone graft material of claim 1 , comprising the steps of:
mixing a collagen with calcium phosphate;
lyophilizing the mixture of collagen and calcium phosphate to form a porous bone graft material; and
disposing, after the lyophilizing, the bioactive glass onto the bone graft material wherein the bone graft material is about 15% to about 20% by weight collagen; about 55% to about 70% by weight bioactive glass; and about 15% to about 30% by weight a calcium phosphate,
wherein said bioactive glass and said calcium phosphate together are about 80% to about 85% by weight of said bone graft material, and
wherein at least 85% of said bioactive glass is particles within a range of 212 μm to about 425 μm.
26. The method of claim 25 , wherein the disposing includes wetting the bone graft material with a solution including the bioactive glass.
27. The method of claim 25 , wherein the disposing includes sprinkling the bioactive glass particles onto the bone graft material.
28. The method of claim 25 , further comprising wetting, after the lyophilizing, the porous bone graft material, wherein the disposing occurs after the wetting.