Process for the separation of organic acids and amino acids from fermentation broths
View Patent ↗The present invention relates to a solid bed adsorptive separation of organic acid and/or amino acids from fermentation broths containing organic acid and/or amino acid.
1. A process for the separation of organic acids from fermentation broths comprising:
i) providing a feed material comprising a fermentation product further comprising an organic acid;
ii) providing an ion exchange adsorbent media; and
iii) separating the organic acid from the feed material by eluting the feed material with a mobile phase through the ion exchange adsorbent media;
wherein there is ionic interaction between the organic acid and the ion exchange adsorbent media, and the mobile phase is a dilute solution of the organic acid.
2. The process of claim 1 wherein the organic acid is lactic acid.
3. The process of claim 1 wherein the organic acid is acetic acid.
4. The process of claim 1 further wherein the separating the organic acid from the feed material by eluting the teed material with a mobile phase through the ion exchange adsorbent media is conducted in a simulated moving bed.
5. A process for the separation of amino acids from fermentation broths comprising:
i) providing a feed material comprising a fermentation product;
ii) providing an ion exchange adsorbent media; and
iii) separating the amino acid from the feed material by eluting the feed material with a mobile phase through the on exchange adsorbent media;
wherein there is ionic interaction between the amino acid and the ion exchange adsorbent media, and the mobile phase is a dilute solution of the amino acid.
6. The process of claim 5 wherein the amino acid is sodium glutamate.
7. The process of claim 5 further wherein the separating the amino acid from the feed material by eluting the feed material with a mobile phase through the ion exchange adsorbent media is conducted in a simulated moving bed.