IP Library Granted Patent US 8,311,618
Granted Patent B2
US 8,311,618 · App. 12/983,451 · Granted Nov 13, 2012

Method and apparatus for quantitative assessment of cardiac electrical events

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Quick Facts
Patent No.
US 8,311,618
App. No.
12/983,451
Granted
Nov 13, 2012
Kind
B2
Abstract

Method and apparatus for computer enabled analysis of ECG (electro cardiographic) data by exploiting computerized three-dimensional spatial presentation of the measured data using vectors. A three-dimensional presentation of the human heart may be correlated with waveforms specific for standard ECG or derived ECG signals based on the dipole approximation of the heart electrical activity. Additional tools for analyzing ECG data are also provided which may be used to determine the time of cardiac electrical events, to select specific beats for automated cardiac interval determination, and to flag ECGs that have been evaluated by automated means but may benefit by human reading.

Claims (88)

1. A computer-assisted method for selecting ECG complexes for further evaluation, the method comprising:

receiving a recorded patient ECG signal comprising a plurality of m ECG complexes; and

using a processor to evaluate ECG complexes of the plurality of m ECG complexes, and to identify a subset of n ECG complexes of the plurality for further evaluation, where n is greater than two and less than m, and wherein the n ECG complexes of the identified subset have a highest degree of similarity to one another relative to any other possible subset of n ECG complexes of the plurality of m ECG complexes.

2. The method of claim 1 , wherein the identified subset of n ECG complexes is identified by applying an autocorrelation function to the m ECG complexes of the plurality of ECG complexes.

3. The method of 2 , wherein the autocorrelation function is

-

f

(

t

+

τ

)

f

_

(

t

)

t

or

-

f

(

t

)

f

_

(

t

-

τ

)

t

where τ is an increment of time t, f is a function and f is the complex conjugate of function f.

4. The method of claim 1 , wherein the identified subset of ECG complexes is identified from virtual ECG data derived from the recorded ECG signal.

5. The method of claim 4 , wherein the virtual ECG data is vector magnitude data or normalized vector magnitude data.

6. The method of claim 1 , wherein the identified subset of n ECG complexes is a first identified subset of n ECG complexes, the method further comprising:

determining a first value of a complex dissimilarity factor for the first identified subset of n ECG complexes;

identifying from the plurality of m ECG complexes a second subset of n ECG complexes, wherein the second identified subset has at least one ECG complex that than is not part of the first identified subset;

determining a second value of a complex dissimilarity factor for the second identified subset; and

if the second value is less than the first value, selecting the second identified subset for further evaluation instead of the first identified subset.

7. A computer-assisted method for selecting ECG complexes for further evaluation, the method comprising:

receiving a recorded patient ECG signal comprising a plurality of m ECG complexes, each ECG complex of the plurality having a duration; and

using a processor to evaluate ECG complexes of the plurality of m ECG complexes, and to identify a subset of n ECG complexes for further evaluation, where n is greater than two and less than m, and wherein the n ECG complexes of the identified subset have a lowest standard deviation in duration out of all possible subsets of n ECG complexes of the plurality of m ECG complexes.

8. A computer-assisted method for selecting ECG complexes upon which to evaluate cardiac events, the method comprising:

receiving a recorded patient ECG signal comprising a plurality of m ECG complexes;

using a processor to evaluate a respective same electrical event in each ECG complex of the plurality of m ECG complexes; and

using a processor to identify a subset of n ECG complexes of the plurality of m ECG complexes, where n is greater than two and less than m, wherein the ECG complexes of the identified subset have a lowest standard deviation in the evaluated electrical event out of all possible subsets of n ECG complexes of the plurality of m ECG complexes.

9. The method of claim 8 , wherein the electrical event is a time interval selected from the group consisting of:

duration of the ECG complex,

PR interval,

RR interval,

QT interval,

rate-corrected QT interval,

time interval between Tpeak and Tend,

time interval between QRSonset and J point,

time interval between Ponset and Pend, and

time interval between peak voltage for R wave and peak voltage for T wave.

10. The method of claim 8 , wherein the electrical event is a voltage selected from the group consisting of:

peak voltage for T wave,

peak voltage for R wave,

peak voltage for P wave.

11. The method of claim 8 , wherein the identified subset of n ECG complexes is a first identified subset of n ECG complexes, the method further comprising:

determining a first value of a complex dissimilarity factor for the first identified subset of n ECG complexes;

identifying from the plurality of m ECG complexes a second subset of n ECG complexes, wherein the second identified subset has at least one ECG complex that is not part of the first identified subset;

determining a second value of a complex dissimilarity factor for the second identified subset; and

if the second value is less than the first value, selecting the second identified subset for further evaluation.

Assignments (15)
RELEASE OF SECURITY INTEREST AT REEL/FRAME 051832/0777 Recorded Jan 17, 2025
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: ERESEARCHTECHNOLOGY, INC.; BIOMEDICAL SYSTEMS LLC (F/K/A BIOMEDICAL SYSTEMS CORPORATION)
Reel/Frame 069939/0212 →
RELEASE OF SECURITY INTEREST AT REEL/FRAME 051837/0001 Recorded Jan 17, 2025
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: ERESEARCHTECHNOLOGY, INC.; BIOMEDICAL SYSTEMS LLC (F/K/A BIOMEDICAL SYSTEMS CORPORATION)
Reel/Frame 069939/0303 →
RELEASE OF SECURITY INTEREST Recorded Feb 7, 2020
From: NEWSTAR FINANCIAL, INC.
To: ERESEARCHTECHNOLOGY, INC.; ICARDIAC TECHNOLOGIES, INC.
Reel/Frame 051754/0867 →
SECOND LIEN SECURITY AGREEMENT Recorded Feb 6, 2020
From: BIOMEDICAL SYSTEMS LLC; ICARDIAC TECHNOLOGIES LLC; ERESEARCHTECHNOLOGY, INC.
To: GOLDMAN SACHS BANK USA
Reel/Frame 051837/0001 →
FIRST LIEN SECURITY AGREEMENT Recorded Feb 5, 2020
From: BIOMEDICAL SYSTEMS LLC; ICARDIAC TECHNOLOGIES LLC; ERESEARCHTECHNOLOGY, INC.
To: GOLDMAN SACHS BANK USA
Reel/Frame 051832/0777 →
RELEASE OF SECURITY INTEREST Recorded Feb 4, 2020
From: GOLDMAN SACHS BANK USA
To: ERESEARCH TECHNOLOGY, INC.; BIOMEDICAL SYSTEMS CORPORATION; ICARDIAC TECHNOLOGIES, INC.
Reel/Frame 051717/0031 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2018
From: ICARDIAC TECHNOLOGIES, INC.
To: ERESEARCHTECHNOLOGY, INC.
Reel/Frame 045720/0645 →
SECURITY AGREEMENT Recorded Nov 27, 2017
From: ICARDIAC TECHNOLOGIES, INC.; ERESEARCHTECHNOLOGY, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 044511/0305 →
RELEASE OF SECURITY INTEREST Recorded Nov 27, 2017
From: SILICON VALLEY BANK
To: ICARDIAC TECHNOLOGIES, INC.
Reel/Frame 044225/0469 →
SECURITY INTEREST Recorded Nov 27, 2017
From: ICARDIAC TECHNOLOGIES, INC.; ERESEARCHTECHNOLOGY, INC.
To: NEWSTAR FINANCIAL, INC., AS COLLATERAL AGENT
Reel/Frame 044224/0125 →
SECURITY AGREEMENT Recorded Mar 3, 2014
From: ICARDIAC TECHNOLOGIES, INC.
To: SILICON VALLEY BANK
Reel/Frame 032382/0906 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2014
From: VISION NC, LLC
To: ICARDIAC TECHNOLOGIES, INC.
Reel/Frame 032315/0279 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2014
From: VISION CAPITAL ADVISORS, LLC
To: VISION NC, LLC
Reel/Frame 032315/0032 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2014
From: VAJDIC, BRANISLAV; LUNGINOVIC, ALEXANDER D.; HADZIEVSKI, LJUPCO; BOJOVIC, BOSKO
To: NEWCARDIO, INC.
Reel/Frame 032314/0633 →
SECURITY AGREEMENT Recorded Dec 27, 2011
From: NEWCARDIO, INC.
To: VISION CAPITAL ADVISORS, LLC
Reel/Frame 027450/0210 →